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Rad1
Gene Detail
 Symbol
Name
ID
Rad1
RAD1 homolog (S. pombe)
MGI:1316678
Feature Type protein coding gene
Genetic Map
Chromosome 15
5.35 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr15:10486018-10499063 bp, + strand
From VEGA annotation of GRCm38

  13046 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37695  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: DNA repair exonuclease RAD1
Gene Tree: Rad1

Human
homologs
Human Homolog RAD1, RAD1 checkpoint DNA exonuclease
NCBI Gene ID 5810
neXtProt AC  NX_O60671
Human Synonyms  HRAD1, REC1
Human Chr (Location)  5p13.2; chr5:34905260-34915675 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(38) : Gene trapped(34) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-in allele exhibit normal B cell DNA damage sensitivity, somatic hypermutation, and class switch recombination.
 
Interactions
Rad1 interacts with 346 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cellular response to DNA damage stimulus, cellular response to ionizing radiation, ...
Component chromosome, intracellular membrane-bounded organelle, ...
Function 3'-5' exonuclease activity, exodeoxyribonuclease III activity, ...
External Resources: FuncBase
Expression
Literature Summary: (3 records)
Data Summary: Results (50)    Tissues (16)    Images (20)
Theiler Stages: 10, 13, 18, 23, 25, 28
Assay TypeResults
RNA in situ 29
Northern blot 21
cDNA source data(32)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) cDNA(32) Other(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000035558 (Evidence)
Ensembl Gene ModelENSMUSG00000022248 (Evidence)
Entrez Gene19355 (Evidence)
UniGene38376
DFCITC1577283, TC1594556, TC1656878
DoTSDT.101339894, DT.101351755, DT.50316579
NIA Mouse Gene IndexU016076
EC3.1.11.2
Consensus CDS ProjectCCDS27379.1, CCDS70618.1
International Mouse Knockout Project StatusRad1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035558 VEGA Gene Model | MGI Sequence Detail 13046 C57BL/6J ±  kb
transcript OTTMUST00000091081 VEGA | MGI Sequence Detail 1514 Not Applicable 
polypeptide OTTMUSP00000050110 VEGA | MGI Sequence Detail 280 Not Applicable 

For the selected sequences
All sequences(63) RefSeq(8) UniProt(4)
Polymorphisms SNPs within 2kb(197 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003011 Cell cycle checkpoint protein, Rad1
InterPro IPR003021 Rad1/Rec1/Rad17
Protein Ontology PR:000013664 cell cycle checkpoint protein RAD1
References (Earliest) J:49553 Freire R, et al., Human and mouse homologs of Schizosaccharomyces pombe rad1(+) and Saccharomyces cerevisiae RAD17: linkage to checkpoint control and mammalian meiosis. Genes Dev. 1998 Aug 15;12(16):2560-73
(Latest) J:183045 Refolio E, et al., The Ddc2/ATRIP checkpoint protein monitors meiotic recombination intermediates. J Cell Sci. 2011 Jul 15;124(Pt 14):2488-500
All references(39)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory