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St3gal3
Gene Detail
Symbol

Name
ID
St3gal3
ST3 beta-galactoside alpha-2,3-sialyltransferase 3
MGI:1316659
Synonyms
Siat3, Siat6, ST3Gal III
Feature Type
protein coding gene
Genetic Map
Chromosome 4
53.84 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:117932154-118134914 bp, - strand
From VEGA annotation of GRCm38

  202761 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7539  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: ST3GAL3
Protein SuperFamily: sialyltransferase
Gene Tree: St3gal3

Human
homologs
ST3GAL3, ST3 beta-galactoside alpha-2,3-sialyltransferase 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 6487
neXtProt AC: NX_Q11203

Human Synonyms: EIEE15, MRT12, SIAT6, ST3GALII, ST3GalIII, ST3N

Human Chr (Location): 1p34.1; chr1:43705824-43931165 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(13) : Gene trapped(11) Targeted(2)
Genomic Mutations involving St3gal3 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for disruptions in this gene show an apparently normal phenotype.
 
Interactions
St3gal3 interacts with 149 markers (Mir7-2, Mir7b, Mir10a, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (5 records)
Data Summary: Results (136)    Tissues (115)    Images (6)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 94
Northern blot 27
RT-PCR 15
cDNA source data(39)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase st3gal3 ; ZFIN st3gal3a, st3gal3b    NEW 
Molecular
reagents
All nucleic(42) cDNA(40) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000008662 (Evidence)
Ensembl Gene Model ENSMUSG00000028538 (Evidence)
Entrez Gene 20441 (Evidence)
UniGene 251002
DFCI TC1580244, TC1609535, TC1596553
DoTS DT.55276342, DT.490356, DT.101366159
NIA Mouse Gene Index U025441
EC 2.4.99.6
Consensus CDS Project CCDS18544.1, CCDS71458.1
International Mouse Phenotyping Consortium Status St3gal3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000008662 VEGA Gene Model | MGI Sequence Detail 202761 C57BL/6J ±  kb
transcript OTTMUST00000019635 VEGA | MGI Sequence Detail 2549 Not Applicable 
polypeptide OTTMUSP00000008999 VEGA | MGI Sequence Detail 374 Not Applicable 

For the selected sequences
All sequences(86) RefSeq(32) UniProt(6)
Polymorphisms
SNPs within 2kb(2032 from dbSNP Build 137)    SNPs within 2kb including multiple locations(2036)
Protein-related
information
ResourceIDDescription
InterPro IPR001675 Glycosyl transferase, family 29
InterPro IPR012163 Sialyltransferase
Protein Ontology PR:000015681 CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase
References
(Earliest) J:41275 Kono M, et al., Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Glycobiology. 1997 Jun;7(4):469-79
(Latest) J:204846 Suzukawa M, et al., Sialyltransferase ST3Gal-III regulates Siglec-F ligand formation and eosinophilic lung inflammation in mice. J Immunol. 2013 Jun 15;190(12):5939-48
All references(38)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory