St3gal3
Gene Detail

Symbol Name ID

St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 MGI:1316659

Synonyms

Siat3, Siat6, ST3Gal III

Feature Type

protein coding gene

Genetic Map

Chromosome 4

53.84 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr4:117932154-118134914 bp, - strand From VEGA annotation of GRCm38   202761 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:7539  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: sialyltransferase
Gene Tree: St3gal3

Human homologs

Human Homolog		ST3GAL3, ST3 beta-galactoside alpha-2,3-sialyltransferase 3
NCBI Gene ID		6487
neXtProt AC		NX_Q11203
Human Synonyms		EIEE15, MRT12, SIAT6, ST3GALII, ST3GalIII, ST3N
Human Chr (Location)		1p34.1; chr1:44173204-44396837 (+)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human ST3GAL3

Alleles and phenotypes

All alleles(12) : Targeted(1) Gene trapped(11)
 

Mice homozygous for disruptions in this gene show an apparently normal phenotype.

 

Gene Ontology (GO) classifications

All GO classifications: (10 annotations)

Process	protein glycosylation
Component	Golgi apparatus, integral to Golgi membrane, ...
Function	beta-galactoside (CMP) alpha-2,3-sialyltransferase activity, N-acetyllactosaminide alpha-2,3-sialyltransferase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (136)    Tissues (108)    Images (6)
Theiler Stages: 12, 22, 28

Assay Type	Results
RNA in situ	94
Northern blot	27
RT-PCR	15

cDNA source data(39)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(42) cDNA(40) Primer pair(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000008662 (Evidence)
Ensembl Gene Model	ENSMUSG00000028538 (Evidence)
Entrez Gene	20441 (Evidence)
UniGene	251002
DFCI	TC1580244, TC1596553, TC1609535
DoTS	DT.101366159, DT.490356, DT.55276342
NIA Mouse Gene Index	U025441
EC	2.4.99.6
Consensus CDS Project	CCDS18544.1
International Mouse Knockout Project Status	St3gal3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000008662	VEGA Gene Model | MGI Sequence Detail	202761	C57BL/6J
transcript	OTTMUST00000019635	VEGA | MGI Sequence Detail	2549	Not Applicable
polypeptide	OTTMUSP00000008999	VEGA | MGI Sequence Detail	374	Not Applicable

All sequences(56) RefSeq(4) UniProt(6)

Polymorphisms

SNPs(1176 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001675	Glycosyl transferase, family 29
InterPro	IPR012163	Sialyltransferase
Protein Ontology	PR:000015681	CMP-N-acetylneuraminate-beta-1,4-galactoside alpha-2,3-sialyltransferase

References

(Earliest) J:41275 Kono M, et al., Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Glycobiology. 1997 Jun;7(4):469-79
(Latest) J:183360 Guo JP, et al., Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs. Am J Respir Cell Mol Biol. 2011 Feb;44(2):238-43
All references(39)