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Prmt2 Gene Detail
Summary
  • Symbol
    Prmt2
  • Name
    protein arginine N-methyltransferase 2
  • Synonyms
    Hrmt1l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316652
    NCBI Gene: 15468
  • Gene Overview
    MyGene.info: PRMT2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr10:76207227-76237857 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      30631 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 38.74 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    PRMT2, protein arginine methyltransferase 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PRMT2, protein arginine methyltransferase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HRMT1L1
  • Links
    NCBI Gene ID: 3275
    neXtProt AC: NX_P55345
    UniProt: P55345

  • Chr Location
    21q22.3; chr21:46635153-46665685 (+)  GRCh38.p7

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display a hyperplastic response to vascular injury while mutant mouse embryonic fibroblasts show an earlier S phase entry following release of serum starvation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020177 VEGA Gene Model | MGI Sequence Detail 30631 C57BL/6J ±  kb
    transcript OTTMUST00000048705 VEGA | MGI Sequence Detail 2100 Not Applicable  
    polypeptide OTTMUSP00000022397 VEGA | MGI Sequence Detail 475 Not Applicable  
    For the selected sequence
    Polymorphisms
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    • SNPs within 2kb
      125 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
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    • All nucleic 113
      Genomic 13
      cDNA 97
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
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    MGI:1354176, MGI:2143632
    References
    more
    • Summaries
      All 68
      Developmental Gene Expression 9
      Diseases 2
      Gene Ontology 8
      Phenotypes 28
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:263863 Hou W, et al., Arginine Methylation by PRMT2 Controls the Functions of the Actin Nucleator Cobl. Dev Cell. 2018 Apr 23;45(2):262-275.e8

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory