About   Help   FAQ
Prmt2
Gene Detail
Symbol

Name
ID
Prmt2
protein arginine N-methyltransferase 2
MGI:1316652
Synonyms
Hrmt1l1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
38.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:76207227-76237857 bp, - strand
From VEGA annotation of GRCm38

  30631 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55587  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: type 1 arginine N-methyltransferase
Gene Tree: Prmt2

Human
homologs
Human Homolog PRMT2, protein arginine methyltransferase 2
NCBI Gene ID 3275
neXtProt AC  NX_P55345
Human Synonyms  HRMT1L1
Human Chr (Location)  21q22.3; chr21:46635595-46665124 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Genomic Mutations involving Prmt2 (4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele display a hyperplastic response to vascular injury while mutant mouse embryonic fibroblasts show an earlier S phase entry following release of serum starvation.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Prmt2 interacts with 104 markers (Mir27a, Mir27b, Mir32, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (247)    Tissues (174)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 229
RT-PCR 18
cDNA source data(96)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(111) Genomic(13) cDNA(96) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000020177 (Evidence)
Ensembl Gene ModelENSMUSG00000020230 (Evidence)
Entrez Gene15468 (Evidence)
UniGene32020
DFCITC1572639, TC1763004, TC1691200
DoTSDT.101271683, DT.101387505, DT.94282502, DT.55100025, DT.110632136, DT.99861526
NIA Mouse Gene IndexU031940
EC2.1.1.-, 2.1.1.125
Consensus CDS ProjectCCDS35942.1
International Mouse Knockout Project StatusPrmt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020177 VEGA Gene Model | MGI Sequence Detail 30631 C57BL/6J ±  kb
transcript OTTMUST00000048705 VEGA | MGI Sequence Detail 2100 Not Applicable 
polypeptide OTTMUSP00000022397 VEGA | MGI Sequence Detail 475 Not Applicable 

For the selected sequences
All sequences(78) RefSeq(9) UniProt(9)
Polymorphisms
SNPs within 2kb(126 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007848 Methyltransferase small domain
InterPro IPR025799 Protein arginine N-methyltransferase
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000013253 protein arginine N-methyltransferase 2
References
(Earliest) J:48150 Cole SE, et al., Physical mapping of the evolutionary boundary between human chromosomes 21 and 22 on mouse chromosome 10. Genomics. 1998 May 15;50(1):109-11
(Latest) J:203762 Burton A, et al., Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo. Cell Rep. 2013 Nov 14;5(3):687-701
All references(55)
Other
accession IDs
MGI:1354176, MGI:2143632

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
12/16/2014
MGI 5.20
The Jackson Laboratory