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Prmt2 Gene Detail
Summary
  • Symbol
    Prmt2
  • Name
    protein arginine N-methyltransferase 2
  • Synonyms
    Hrmt1l1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316652
    NCBI Gene: 15468
  • Gene Overview
    MyGene.info: PRMT2
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:76207226-76237865 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 10, 38.74 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    125 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316652
protein coding gene Chr10:76207222-76237865 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017378
protein coding gene Chr10:76433281-76466031 (-)
A/J MGP_AJ_G0017355
protein coding gene Chr10:73796707-73827657 (-)
AKR/J MGP_AKRJ_G0017316
protein coding gene Chr10:75787894-75818560 (-)
BALB/cJ MGP_BALBcJ_G0017315
protein coding gene Chr10:73998929-74031431 (-)
C3H/HeJ MGP_C3HHeJ_G0017139
protein coding gene Chr10:75851329-75886061 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017773
protein coding gene Chr10:79134912-79172250 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015463
protein coding gene Chr10:70250652-70280434 (-)
CAST/EiJ MGP_CASTEiJ_G0016709
protein coding gene Chr10:76173948-76204234 (-)
CBA/J MGP_CBAJ_G0017111
protein coding gene Chr10:82233257-82266813 (-)
DBA/2J MGP_DBA2J_G0017216
protein coding gene Chr10:73108461-73140244 (-)
FVB/NJ MGP_FVBNJ_G0017208
protein coding gene Chr10:72261043-72293595 (-)
LP/J MGP_LPJ_G0017289
protein coding gene Chr10:76947601-76979036 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017237
protein coding gene Chr10:84303815-84337648 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017812
protein coding gene Chr10:75835472-75870425 (-)
PWK/PhJ MGP_PWKPhJ_G0016493
protein coding gene Chr10:72937528-72969047 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016276
protein coding gene Chr10:75066532-75099994 (-)
WSB/EiJ MGP_WSBEiJ_G0016772
protein coding gene Chr10:75816242-75847883 (-)



Homology
more
  • Human Ortholog
    PRMT2, protein arginine methyltransferase 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PRMT2, protein arginine methyltransferase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HRMT1L1
  • Links
    NCBI Gene ID: 3275
    neXtProt AC: NX_P55345
    UniProt: P55345

  • Chr Location
    21q22.3; chr21:46635153-46665685 (+)  GRCh38.p7

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display a hyperplastic response to vascular injury while mutant mouse embryonic fibroblasts show an earlier S phase entry following release of serum starvation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 15468 NCBI Gene Model | MGI Sequence Detail 30640 C57BL/6J ±  kb
    transcript NM_001302965 RefSeq | MGI Sequence Detail 2146 C57BL/6  
    polypeptide Q9R144 UniProt | EBI | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 113
      Genomic 13
      cDNA 97
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:1354176, MGI:2143632
    References
    more
    • Summaries
      All 69
      Developmental Gene Expression 11
      Diseases 2
      Gene Ontology 9
      Phenotypes 28
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:264087 Sato A, et al., Gestational changes in PRMT1 expression of murine placentas. Placenta. 2018 May;65:47-54

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory