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Prmt2
Gene Detail
Symbol

Name
ID
Prmt2
protein arginine N-methyltransferase 2
MGI:1316652
Synonyms
Hrmt1l1
Feature Type
protein coding gene
Genetic Map
Chromosome 10
38.74 cM
Detailed Genetic Map ± 1 cM


Mapping data(6)
Sequence Map
Chr10:76207227-76237857 bp, - strand
From VEGA annotation of GRCm38

  30631 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55587  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: PRMT2
Protein SuperFamily: type 1 arginine N-methyltransferase
Gene Tree: Prmt2

Human
homologs
PRMT2, protein arginine methyltransferase 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3275
neXtProt AC: NX_P55345

Human Synonyms: HRMT1L1

Human Chr (Location): 21q22.3; chr21:46635153-46665685 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Targeted(9)
Genomic Mutations involving Prmt2 (4)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a knock-out allele display a hyperplastic response to vascular injury while mutant mouse embryonic fibroblasts show an earlier S phase entry following release of serum starvation.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Prmt2 interacts with 104 markers (Mir27a, Mir27b, Mir32, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (9 records)
Data Summary: Results (247)    Tissues (174)    Images (23)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 229
RT-PCR 18
cDNA source data(96)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: Xenbase prmt2    NEW 
Molecular
reagents
All nucleic(111) Genomic(13) cDNA(96) Primer pair(2)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000020177 (Evidence)
Ensembl Gene Model ENSMUSG00000020230 (Evidence)
Entrez Gene 15468 (Evidence)
UniGene 32020
DFCI TC1691200, TC1572639, TC1763004
DoTS DT.94282502, DT.99861526, DT.55100025, DT.110632136, DT.101387505, DT.101271683
NIA Mouse Gene Index U031940
EC 2.1.1.-, 2.1.1.125
Consensus CDS Project CCDS35942.1
International Mouse Phenotyping Consortium Status Prmt2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020177 VEGA Gene Model | MGI Sequence Detail 30631 C57BL/6J ±  kb
transcript OTTMUST00000048705 VEGA | MGI Sequence Detail 2100 Not Applicable 
polypeptide OTTMUSP00000022397 VEGA | MGI Sequence Detail 475 Not Applicable 

For the selected sequences
All sequences(73) RefSeq(7) UniProt(5)
Polymorphisms
SNPs within 2kb(126 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007848 Methyltransferase small domain
InterPro IPR025799 Protein arginine N-methyltransferase
InterPro IPR001452 Src homology-3 domain
Protein Ontology PR:000013253 protein arginine N-methyltransferase 2
References
(Earliest) J:48150 Cole SE, et al., Physical mapping of the evolutionary boundary between human chromosomes 21 and 22 on mouse chromosome 10. Genomics. 1998 May 15;50(1):109-11
(Latest) J:203762 Burton A, et al., Single-cell profiling of epigenetic modifiers identifies PRDM14 as an inducer of cell fate in the mammalian embryo. Cell Rep. 2013 Nov 14;5(3):687-701
All references(54)
Other
accession IDs
MGI:1354176, MGI:2143632

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/20/2015
MGI 5.22
The Jackson Laboratory