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Slc37a4
Gene Detail
 Symbol
Name
ID
Slc37a4
solute carrier family 37 (glucose-6-phosphate transporter), member 4
MGI:1316650
Synonyms G6PT, G6pt1
Feature Type protein coding gene
Genetic Map
Chromosome 9
24.84 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(5)
Sequence Map
Chr9:44398176-44402963 bp, + strand
From Ensembl annotation of GRCm38

  4788 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37482  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 zebrafish

Protein SuperFamily: Hexose_phosphate_transp
Gene Tree: Slc37a4

Human
homologs
Human Homolog SLC37A4, solute carrier family 37 (glucose-6-phosphate transporter), member 4
NCBI Gene ID 2542
neXtProt AC  NX_O43826
Human Synonyms  G6PT1, G6PT2, G6PT3, GSD1b, GSD1c, GSD1d, TRG19, TRG-19
Human Chr (Location)  11q23.3; chr11:119024351-119030906 (-)  GRCh38
Disease Associations  (2) Diseases Associated with Human SLC37A4
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
Incidental mutations (data from APF )
 
Homozygous null mice exhibit disrupted glucose homeostasis, transient neutropenia associated with impaired neutrophil trafficking and function. Mice are growth retarded and, without glucose therapy, die postnatally.
 
Human Diseases Modeled Using Mouse Slc37a4 (1)    Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (29 annotations)
Process cellular calcium ion homeostasis, cholesterol homeostasis, ...
Component integral component of endoplasmic reticulum membrane, intracellular membrane-bounded organelle, ...
Function glucose-6-phosphate transmembrane transporter activity
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (146)    Tissues (112)    Images (14)
Theiler Stages: 22, 23, 24, 25, 26, 28
Assay TypeResults
RNA in situ 102
Northern blot 36
RT-PCR 8
cDNA source data(7)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(11) cDNA(7) Primer pair(3) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032114 (Evidence)
Entrez Gene14385 (Evidence)
DFCITC1575944, TC1694766
DoTSDT.101258693, DT.110579189, DT.532072, DT.97395325, DT.99858056
NIA Mouse Gene IndexU010386
Consensus CDS ProjectCCDS23108.1
International Mouse Knockout Project StatusSlc37a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032114 Ensembl Gene Model | MGI Sequence Detail 4788 C57BL/6J ±  kb
transcript ENSMUST00000165839 Ensembl | MGI Sequence Detail 2083 Not Applicable 
polypeptide ENSMUSP00000129564 Ensembl | MGI Sequence Detail 429 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(16) UniProt(2)
Polymorphisms SNPs within 2kb(70 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021159 Glycerate/sugar phosphate transporter, conserved site
InterPro IPR011701 Major facilitator superfamily
InterPro IPR020846 Major facilitator superfamily domain
InterPro IPR016196 Major facilitator superfamily domain, general substrate transporter
InterPro IPR000849 Sugar phosphate transporter
Protein Ontology PR:000015117 glucose-6-phosphate translocase
References (Earliest) J:51217 Lin B, et al., Cloning and characterization of cDNAs encoding a candidate glycogen storage disease type 1b protein in rodents. J Biol Chem. 1998 Nov 27;273(48):31656-60
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(41)
Other
accession IDs
MGI:3782457

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/15/2014
MGI 5.18
The Jackson Laboratory