Slc37a4
Gene Detail

Symbol Name ID

Slc37a4 solute carrier family 37 (glucose-6-phosphate transporter), member 4 MGI:1316650

Synonyms

G6PT, G6pt1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

24.84 cM, cytoband B
Detailed Genetic Map ± 1 cM


Mapping data(5)

Sequence Map

Chr9:44398176-44402963 bp, + strand From Ensembl annotation of GRCm38   4788 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:37482  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: Hexose_phosphate_transp
Gene Tree: Slc37a4

Human homologs

Human Homolog		SLC37A4, solute carrier family 37 (glucose-6-phosphate transporter), member 4
NCBI Gene ID		2542
neXtProt AC		NX_O43826
Human Synonyms		G6PT1, G6PT2, G6PT3, GSD1b, GSD1c, GSD1d, TRG19, TRG-19
Human Chr (Location)		11q23.3; chr11:118895061-118901616 (-)  GRCh37.p10
Disease Associations		(2) Diseases Associated with Human SLC37A4

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygous null mice exhibit disrupted glucose homeostasis, transient neutropenia associated with impaired neutrophil trafficking and function. Mice are growth retarded and, without glucose therapy, die postnatally.

 
Human Diseases Modeled Using Mouse Slc37a4 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (26 annotations)

Process	cellular calcium ion homeostasis, cholesterol homeostasis, ...
Component	integral to endoplasmic reticulum membrane, intracellular membrane-bounded organelle
Function	glucose-6-phosphate transmembrane transporter activity

This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase

Expression

Literature Summary: (4 records)
Data Summary: Results (146)    Tissues (112)    Images (14)
Theiler Stages: 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	102
Northern blot	36
RT-PCR	8

cDNA source data(106)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(110) cDNA(106) Primer pair(3) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032114 (Evidence)
Entrez Gene	14385 (Evidence)
UniGene	30087
DFCI	TC1575944
DoTS	DT.101258693, DT.532072, DT.97395325, DT.99858056
NIA Mouse Gene Index	U010386
Consensus CDS Project	CCDS23108.1
International Mouse Knockout Project Status	Slc37a4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032114	Ensembl Gene Model | MGI Sequence Detail	4788	C57BL/6J
transcript	ENSMUST00000165839	Ensembl | MGI Sequence Detail	2083	Not Applicable
polypeptide	ENSMUSP00000129564	Ensembl | MGI Sequence Detail	429	Not Applicable

All sequences(23) RefSeq(2) UniProt(2)

Polymorphisms

SNPs(42 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR021159	Glycerate/sugar phosphate transporter, conserved site
InterPro	IPR011701	Major facilitator superfamily
InterPro	IPR020846	Major facilitator superfamily domain
InterPro	IPR016196	Major facilitator superfamily domain, general substrate transporter
InterPro	IPR000849	Sugar phosphate transporter
Protein Ontology	PR:000015117	glucose-6-phosphate translocase

References

(Earliest) J:51217 Lin B, et al., Cloning and characterization of cDNAs encoding a candidate glycogen storage disease type 1b protein in rodents. J Biol Chem. 1998 Nov 27;273(48):31656-60
(Latest) J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42
All references(42)

Other accession IDs

MGI:3782457