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Slc37a4 Gene Detail
Summary
  • Symbol
    Slc37a4
  • Name
    solute carrier family 37 (glucose-6-phosphate transporter), member 4
  • Synonyms
    G6PT, G6pt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316650
    NCBI Gene: 14385
  • Gene Overview
    MyGene.info: SLC37A4
Location & Maps
more
  • Sequence Map
    Chr9:44398176-44402963 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      4788 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    5 experiments
Homology
more
  • Human Ortholog
    SLC37A4, solute carrier family 37 member 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SLC37A4, solute carrier family 37 member 4
    Orthology source: HomoloGene
  • Synonyms
    G6PT1, G6PT2, G6PT3, GSD1b, GSD1c, GSD1d, PRO0685, TRG19, TRG-19
  • Links
    NCBI Gene ID: 2542
    neXtProt AC: NX_O43826

  • Chr Location
    11q23.3; chr11:119024351-119030906 (-)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Slc37a4 mouse models; 2 with human SLC37A4 associations

Human Disease Mouse Models
       Glycogen Storage Disease IB; GSD1B   OMIM: 232220 View 1 model
       Glycogen Storage Disease Ic; GSD1C   OMIM: 232240
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 1 allele in 1 genetic background
    7 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    4
  • Targeted
    4
  • Incidental Mutations
    APF , CvDC
Homozygous null mice exhibit disrupted glucose homeostasis, transient neutropenia associated with impaired neutrophil trafficking and function. Mice are growth retarded and, without glucose therapy, die postnatally.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032114 Ensembl Gene Model | MGI Sequence Detail 4788 C57BL/6J ±  kb
transcript ENSMUST00000165839 Ensembl | MGI Sequence Detail 2083 Not Applicable  
polypeptide ENSMUSP00000129564 Ensembl | MGI Sequence Detail 429 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    77 from dbSNP Build 142
Protein
Information
less
  • UniProt
    2 Sequences
  • InterPro Domains
    IPR021159 Glycerate/sugar phosphate transporter, conserved site
    IPR011701 Major facilitator superfamily
    IPR020846 Major facilitator superfamily domain
    IPR000849 Sugar phosphate transporter
Molecular
Reagents
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  • All nucleic 11
    cDNA 7
    Primer pair 3
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:3782457
References
more
  • Summaries
    All 37
    Developmental Gene Expression 4
    Diseases 1
    Gene Ontology 8
    Phenotypes 7
  • Earliest
    J:51217 Lin B, et al., Cloning and characterization of cDNAs encoding a candidate glycogen storage disease type 1b protein in rodents. J Biol Chem. 1998 Nov 27;273(48):31656-60
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/17/2016
MGI 6.05
The Jackson Laboratory