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Slc37a4 Gene Detail
Summary
  • Symbol
    Slc37a4
  • Name
    solute carrier family 37 (glucose-6-phosphate transporter), member 4
  • Synonyms
    G6PT, G6pt1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316650
    NCBI Gene: 14385
  • Gene Overview
    MyGene.info: SLC37A4
  • Alliance
  • Transcription Start Sites
    8 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:44396857-44402968 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 24.84 cM, cytoband B
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    77 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316650
protein coding gene Chr9:44396852-44402968 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034706
protein coding gene Chr9:42882465-42888468 (+)
A/J MGP_AJ_G0034687
protein coding gene Chr9:41685408-41690927 (+)
AKR/J MGP_AKRJ_G0034613
protein coding gene Chr9:42547481-42553475 (+)
BALB/cJ MGP_BALBcJ_G0034678
protein coding gene Chr9:41432746-41438755 (+)
C3H/HeJ MGP_C3HHeJ_G0034389
protein coding gene Chr9:43005132-43011284 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035199
protein coding gene Chr9:44156894-44162413 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032114
protein coding gene Chr9:41265401-41270190 (+)
CAST/EiJ MGP_CASTEiJ_G0033711
protein coding gene Chr9:42853355-42859380 (+)
CBA/J MGP_CBAJ_G0034361
protein coding gene Chr9:45751489-45757071 (+)
DBA/2J MGP_DBA2J_G0034520
protein coding gene Chr9:41587742-41593762 (+)
FVB/NJ MGP_FVBNJ_G0034461
protein coding gene Chr9:40842812-40848386 (+)
LP/J MGP_LPJ_G0034601
protein coding gene Chr9:43184859-43190845 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034505
protein coding gene Chr9:47605654-47611507 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035220
protein coding gene Chr9:42448809-42454664 (+)
PWK/PhJ MGP_PWKPhJ_G0033417
protein coding gene Chr9:41462061-41466840 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033251
protein coding gene Chr9:42771498-42777342 (+)
WSB/EiJ MGP_WSBEiJ_G0033824
protein coding gene Chr9:42488529-42494676 (+)



Homology
more
  • Human Ortholog
    SLC37A4, solute carrier family 37 member 4
  • Vertebrate Orthologs
    11
  • Human Ortholog
    SLC37A4, solute carrier family 37 member 4
    Orthology source: HomoloGene, HGNC
  • Synonyms
    G6PT1, G6PT2, G6PT3, GSD1b, GSD1c, GSD1d, PRO0685, TRG19, TRG-19
  • Links
    NCBI Gene ID: 2542
    neXtProt AC: NX_O43826
    UniProt: O43826

  • Chr Location
    11q23.3; chr11:119024351-119030906 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Slc37a4 mouse models; 1 with human SLC37A4 associations

Human Disease Mouse Models
      
IDs
View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 1 allele in 1 genetic background
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit disrupted glucose homeostasis, transient neutropenia associated with impaired neutrophil trafficking and function. Mice are growth retarded and, without glucose therapy, die postnatally.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14385 NCBI Gene Model | MGI Sequence Detail 6112 C57BL/6J ±  kb
    transcript NM_001357729 RefSeq | MGI Sequence Detail 2438 C57BL/6  
    polypeptide NP_001344658 RefSeq | MGI Sequence Detail 450 C57BL/6  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • InterPro Domains
      IPR021159 Glycerate/sugar phosphate transporter, conserved site
      IPR011701 Major facilitator superfamily
      IPR020846 Major facilitator superfamily domain
      IPR036259 MFS transporter superfamily
      IPR000849 Sugar phosphate transporter
    Molecular
    Reagents
    less
    • All nucleic 12
      cDNA 8
      Primer pair 3
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:3782457
    References
    more
    • Summaries
      All 40
      Developmental Gene Expression 4
      Diseases 1
      Gene Ontology 7
      Phenotypes 9
    • Earliest
      J:51217 Lin B, et al., Cloning and characterization of cDNAs encoding a candidate glycogen storage disease type 1b protein in rodents. J Biol Chem. 1998 Nov 27;273(48):31656-60
    • Latest
      J:242247 Kim GY, et al., Downregulation of pathways implicated in liver inflammation and tumorigenesis of glycogen storage disease type Ia mice receiving gene therapy. Hum Mol Genet. 2017 May 15;26(10):1890-1899

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory