About   Help   FAQ
Sphk1 Gene Detail
Summary
  • Symbol
    Sphk1
  • Name
    sphingosine kinase 1
  • Synonyms
    1110006G24Rik, SK1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1316649
    NCBI Gene: 20698
  • Gene Overview
    MyGene.info: SPHK1
  • Alliance
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116530925-116536674 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 81.42 cM, cytoband E2
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    35 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1316649
protein coding gene Chr11:116530836-116536675 (.)
129S1/SvImJ MGP_129S1SvImJ_G0019430
protein coding gene Chr11:120665620-120671365 (+)
A/J MGP_AJ_G0019398
protein coding gene Chr11:115382786-115388533 (+)
AKR/J MGP_AKRJ_G0019369
protein coding gene Chr11:118817432-118823181 (+)
BALB/cJ MGP_BALBcJ_G0019373
protein coding gene Chr11:115782391-115788136 (+)
C3H/HeJ MGP_C3HHeJ_G0019179
protein coding gene Chr11:119174210-119179957 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019822
protein coding gene Chr11:124347360-124353109 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017446
protein coding gene Chr11:112381990-112387701 (+)
CAST/EiJ MGP_CASTEiJ_G0018734
protein coding gene Chr11:120549394-120555146 (+)
CBA/J MGP_CBAJ_G0019150
protein coding gene Chr11:129276971-129282718 (+)
DBA/2J MGP_DBA2J_G0019262
protein coding gene Chr11:114811730-114817475 (+)
FVB/NJ MGP_FVBNJ_G0019254
protein coding gene Chr11:114313861-114319606 (+)
LP/J MGP_LPJ_G0019332
protein coding gene Chr11:121048843-121054618 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0019287
protein coding gene Chr11:128314194-128319939 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019861
protein coding gene Chr11:119482008-119487753 (+)
PWK/PhJ MGP_PWKPhJ_G0018498
protein coding gene Chr11:116135792-116141620 (+)
SPRET/EiJ MGP_SPRETEiJ_G0018291
protein coding gene Chr11:119230241-119235971 (+)
WSB/EiJ MGP_WSBEiJ_G0018786
protein coding gene Chr11:119445589-119453625 (+)



Homology
more
  • Human Ortholog
    SPHK1, sphingosine kinase 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SPHK1, sphingosine kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    SPHK
  • Links
    NCBI Gene ID: 8877
    neXtProt AC: NX_Q9NYA1
    UniProt: Q9NYA1

  • Chr Location
    17q25.1; chr17:76382977-76387860 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 39748
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SPHK1
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 3 alleles in 4 genetic backgrounds
    35 phenotypes from multigenic genotypes
    2 images
    90 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are viable, fertile, and without any obvious abnormalities.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000061878 Ensembl Gene Model | MGI Sequence Detail 5750 C57BL/6J ±  kb
    transcript ENSMUST00000141798 Ensembl | MGI Sequence Detail 1532 Not Applicable  
    polypeptide ENSMUSP00000131010 Ensembl | MGI Sequence Detail 388 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 55
      cDNA 54
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:1913372
    References
    more
    • Summaries
      All 167
      Developmental Gene Expression 12
      Gene Ontology 9
      Phenotypes 90
    • Earliest
      J:49744 Kohama T, et al., Molecular cloning and functional characterization of murine sphingosine kinase. J Biol Chem. 1998 Sep 11;273(37):23722-8
    • Latest
      J:263557 Riento K, et al., Flotillin proteins recruit sphingosine to membranes and maintain cellular sphingosine-1-phosphate levels. PLoS One. 2018;13(5):e0197401

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/11/2018
    MGI 6.13
    The Jackson Laboratory