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Sphk1
Gene Detail
Symbol

Name
ID
Sphk1
sphingosine kinase 1
MGI:1316649
Synonyms
1110006G24Rik, SK1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
81.42 cM, cytoband E2
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:116530925-116536674 bp, + strand
From VEGA annotation of GRCm38

  5750 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:39748  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Sphk1

Human
homologs
Human Homolog SPHK1, sphingosine kinase 1
NCBI Gene ID 8877
neXtProt AC  NX_Q9NYA1
Human Synonyms  SPHK
Human Chr (Location)  17q25.2; chr17:76383163-76387860 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice are viable, fertile, and without any obvious abnormalities.
 
Interactions
Sphk1 interacts with 30 markers (Mir22, Mir92-1, Mir125b-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (53 annotations)
Process blood vessel development, brain development, ...
Component axon, cytoplasm, ...
Function ATP binding, calmodulin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (9 records)
Data Summary: Results (24)    Tissues (24)    Images (1)    Tissue x Stage Matrix (view)
Assay TypeResults
Northern blot 12
RT-PCR 12
cDNA source data(50)
External Resources: GEO   Expression Atlas
Molecular
reagents
All nucleic(55) cDNA(54) Primer pair(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000003900 (Evidence)
Ensembl Gene ModelENSMUSG00000061878 (Evidence)
Entrez Gene20698 (Evidence)
UniGene20944
DFCITC1594715, TC1599040, TC1599268, TC1601818, TC1616931, TC1670291
DoTSDT.101359149, DT.489693, DT.91436427, DT.94177978, DT.97414836
EC2.7.1.91
Consensus CDS ProjectCCDS25668.1, CCDS25669.1, CCDS48986.1
International Mouse Knockout Project StatusSphk1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000003900 VEGA Gene Model | MGI Sequence Detail 5750 C57BL/6J ±  kb
transcript OTTMUST00000008633 VEGA | MGI Sequence Detail 1532 Not Applicable 
polypeptide OTTMUSP00000051871 VEGA | MGI Sequence Detail 388 Not Applicable 

For the selected sequences
All sequences(115) RefSeq(24) UniProt(8)
Polymorphisms
SNPs within 2kb(32 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016064 ATP-NAD kinase-like domain
InterPro IPR001206 Diacylglycerol kinase, catalytic domain
Protein Ontology PR:000015522 sphingosine kinase 1
References
(Earliest) J:49744 Kohama T, et al., Molecular cloning and functional characterization of murine sphingosine kinase. J Biol Chem. 1998 Sep 11;273(37):23722-8
(Latest) J:212616 Albinet V, et al., Dual role of sphingosine kinase-1 in promoting the differentiation of dermal fibroblasts and the dissemination of melanoma cells. Oncogene. 2014 Jun 26;33(26):3364-73
All references(123)
Other
accession IDs
MGI:1913372

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory