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Ahnak
Gene Detail
Symbol

Name
ID
Ahnak
AHNAK nucleoprotein (desmoyokin)
MGI:1316648
Synonyms
1110004P15Rik, 2310047C17Rik, DY6
Feature Type
protein coding gene
Genetic Map
Chromosome 19
6.04 cM, cytoband A
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:8989284-9076919 bp, + strand
From Ensembl annotation of GRCm38

  87636 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:67425  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AHNAK
Gene Tree: Ahnak

Human
homologs
AHNAK, AHNAK nucleoprotein
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 79026
neXtProt AC: NX_Q09666

Human Synonyms: AHNAKRS

Human Chr (Location): 11q12.2; chr11:62433542-62546860 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(138) : Gene trapped(132) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for one knock-out allele exhibit decreased T cell proliferation and increased susceptibility to parasitic infection.
 
Interactions
Ahnak interacts with 324 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process protein oligomerization, regulation of RNA splicing, ...
Component actin cytoskeleton, cell-cell contact zone, ...
Function poly(A) RNA binding, S100 protein binding, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (125)    Tissues (72)    Images (53)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 101
RNA in situ 24
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase ahnak    NEW 
Molecular
reagents
All nucleic(17) cDNA(16) Other(1)
Microarray probesets(8)
Other database
links
Ensembl Gene Model ENSMUSG00000069833 (Evidence)
Entrez Gene 66395 (Evidence)
DFCI TC1585881, TC1596323, TC1597172, TC1597484, TC1641995, TC1662473
DoTS DT.101400384, DT.110858611, DT.110858623, DT.40143554, DT.535125, DT.94122881
NIA Mouse Gene Index U168837
Consensus CDS Project CCDS29564.1, CCDS50384.1
International Mouse Phenotyping Consortium Status Ahnak
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000069833 Ensembl Gene Model | MGI Sequence Detail 87636 C57BL/6J ±  kb
transcript ENSMUST00000092956 Ensembl | MGI Sequence Detail 18099 Not Applicable 
polypeptide ENSMUSP00000090633 Ensembl | MGI Sequence Detail 5656 Not Applicable 

For the selected sequences
All sequences(80) RefSeq(23) UniProt(12)
Polymorphisms
SNPs within 2kb(277 from dbSNP Build 137)    SNPs within 2kb including multiple locations(279)
Protein-related
information
ResourceIDDescription
InterPro IPR002068 Alpha crystallin/Hsp20 domain
InterPro IPR001478 PDZ domain
Protein Ontology PR:000003856 neuroblast differentiation-associated protein AHNAK
References
(Earliest) J:51303 Hashimoto T, et al., Desmoyokin, a 680 kDa keratinocyte plasma membrane-associated protein, is homologous to the protein encoded by human gene AHNAK. J Cell Sci. 1993 Jun;105(Pt 2):275-86
(Latest) J:214424 Lee IH, et al., Ahnak functions as a tumor suppressor via modulation of TGFbeta/Smad signaling pathway. Oncogene. 2014 Sep 18;33(38):4675-84
All references(52)
Other
accession IDs
MGI:1913645, MGI:1920976, MGI:2147451, MGI:2147673

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory