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Dhrs3
Gene Detail
Symbol

Name
ID
Dhrs3
dehydrogenase/reductase (SDR family) member 3
MGI:1315215
Synonyms
retSDR1, Rsdr1
Feature Type
protein coding gene
Genetic Map
Chromosome 4
78.14 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr4:144892827-144928209 bp, + strand
From VEGA annotation of GRCm38

  35383 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20994  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: DHRS3
Protein SuperFamily: 11-beta-HSD1
Gene Tree: Dhrs3

Human
homologs
DHRS3, dehydrogenase/reductase (SDR family) member 3
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 9249
neXtProt AC: NX_O75911

Human Synonyms: DD83.1, RDH17, retSDR1, Rsdr1, SDR1, SDR16C1

Human Chr (Location): 1p36.1; chr1:12567910-12618361 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Gene trapped(1) Targeted(3)
Genomic Mutations involving Dhrs3 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a targeted mutation die before weaning age. Mice homozygous for a gene trap allele exhibit perinatal lethality, altered retinoid metabolism and heart, craniofacial and skeletal defects.
 
Interactions
Dhrs3 interacts with 199 markers (Mir19b-1, Mir19b-2, Mir29b-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process bone morphogenesis, cardiac septum morphogenesis, ...
Component integral component of membrane, membrane
Function NADP-retinol dehydrogenase activity, oxidoreductase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (172)    Tissues (143)    Images (41)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 172
cDNA source data(56)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA DHRS3 ; Xenbase dhrs3 ; ZFIN dhrs3a, dhrs3b    NEW 
Molecular
reagents
All nucleic(58) cDNA(58)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000010749 (Evidence)
Ensembl Gene Model ENSMUSG00000066026 (Evidence)
Entrez Gene 20148 (Evidence)
UniGene 14063
DFCI TC1682520, TC1593077, TC1577163
DoTS DT.91342975, DT.91304022, DT.528960, DT.94337535
NIA Mouse Gene Index U005072
EC 1.1.1.300
Consensus CDS Project CCDS18912.1, CCDS51368.1
International Mouse Phenotyping Consortium Status Dhrs3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010749 VEGA Gene Model | MGI Sequence Detail 35383 C57BL/6J ±  kb
transcript OTTMUST00000025109 VEGA | MGI Sequence Detail 2337 Not Applicable 
polypeptide OTTMUSP00000011509 VEGA | MGI Sequence Detail 302 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(12) UniProt(4)
Polymorphisms
SNPs within 2kb(355 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR002347 Glucose/ribitol dehydrogenase
InterPro IPR016040 NAD(P)-binding domain
InterPro IPR002198 Short-chain dehydrogenase/reductase SDR
Protein Ontology PR:000006465 short-chain dehydrogenase/reductase 3
References
(Earliest) J:49273 Haeseleer F, et al., Molecular characterization of a novel short-chain dehydrogenase/reductase that reduces all-trans-retinal. J Biol Chem. 1998 Aug 21;273(34):21790-9
(Latest) J:214109 Adams MK, et al., The retinaldehyde reductase activity of DHRS3 is reciprocally activated by retinol dehydrogenase 10 to control retinoid homeostasis. J Biol Chem. 2014 May 23;289(21):14868-80
All references(35)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory