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Nrip1 Gene Detail
Summary
  • Symbol
    Nrip1
  • Name
    nuclear receptor interacting protein 1
  • Synonyms
    6030458L20Rik, 8430438I05Rik, RIP140
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315213
    NCBI Gene: 268903
  • Gene Overview
    MyGene.info: NRIP1
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr16:76287400-76373827 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      86428 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 43.65 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NRIP1, nuclear receptor interacting protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NRIP1, nuclear receptor interacting protein 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    RIP140
  • Links
    NCBI Gene ID: 8204
    neXtProt AC: NX_P48552
    UniProt: P48552

  • Chr Location
    21q11.2-q21.1; chr21:14961235-15065903 (-)  GRCh38.p7

Human Diseases
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  • Mutations/Alleles
    1 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    20 phenotypes from multigenic genotypes
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygosity for targeted disruption of this gene results in female infertility due to ovulation failure. Heterozygous females are partially affected. Male and female mice are smaller than wild-type littermates.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000026674 VEGA Gene Model | MGI Sequence Detail 86428 C57BL/6J ±  kb
    transcript OTTMUST00000066003 VEGA | MGI Sequence Detail 7868 Not Applicable  
    polypeptide OTTMUSP00000032982 VEGA | MGI Sequence Detail 1161 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      518 from dbSNP Build 142
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000011427 nuclear receptor-interacting protein 1
    • InterPro Domains
      IPR026649 Nuclear receptor-interacting protein 1
      IPR031405 Nuclear receptor-interacting protein 1, repression domain 1
      IPR031406 Nuclear receptor-interacting protein 1, repression domain 2
      IPR031407 Nuclear receptor-interacting protein 1, repression domain 3
      IPR031408 Nuclear receptor-interacting protein 1, repression domain 4
    Molecular
    Reagents
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    • All nucleic 25
      cDNA 22
      Primer pair 2
      Other 1

      Microarray probesets 9
    Other
    Accession IDs
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    MGI:1918801, MGI:1925132, MGI:2146368, MGI:2146638
    References
    more
    • Summaries
      All 97
      Developmental Gene Expression 14
      Diseases 2
      Gene Ontology 18
      Phenotypes 32
    • Earliest
      J:46180 Katsanis N, et al., Localisation of receptor interacting protein 140 (RIP140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome. Hum Genet. 1998 Feb;102(2):221-3
    • Latest
      J:254654 Vivante A, et al., A Dominant Mutation in Nuclear Receptor Interacting Protein 1 Causes Urinary Tract Malformations via Dysregulation of Retinoic Acid Signaling. J Am Soc Nephrol. 2017 Aug;28(8):2364-2376

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory