About   Help   FAQ
Nrip1
Gene Detail
Symbol

Name
ID
Nrip1
nuclear receptor interacting protein 1
MGI:1315213
Synonyms
6030458L20Rik, 8430438I05Rik, RIP140
Feature Type
protein coding gene
Genetic Map
Chromosome 16
43.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:76287400-76373827 bp, - strand
From VEGA annotation of GRCm38

  86428 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2606  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: NRIP1
Protein SuperFamily: nuclear receptor-interacting protein 1
Gene Tree: Nrip1

Human
homologs
NRIP1, nuclear receptor interacting protein 1
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8204
neXtProt AC: NX_P48552

Human Synonyms: RIP140

Human Chr (Location): 21q11.2; chr21:14961235-15065903 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(162) : Gene trapped(157) Targeted(5)
Genomic Mutations involving Nrip1 (3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygosity for targeted disruption of this gene results in female infertility due to ovulation failure. Heterozygous females are partially affected. Male and female mice are smaller than wild-type littermates.
 
Phenotype Images(2)
Interactions
Nrip1 interacts with 446 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (12 records)
Data Summary: Results (327)    Tissues (199)    Images (54)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 300
Northern blot 9
RT-PCR 18
cDNA source data(17)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase nrip1 ; ZFIN nrip1b    NEW 
Molecular
reagents
All nucleic(25) cDNA(22) Primer pair(2) Other(1)
Microarray probesets(9)
Other database
links
VEGA Gene Model OTTMUSG00000026674 (Evidence)
Ensembl Gene Model ENSMUSG00000048490 (Evidence)
Entrez Gene 268903 (Evidence)
DFCI TC1580836, TC1599100, TC1635838
DoTS DT.101219964, DT.102551107, DT.40146258, DT.524225
NIA Mouse Gene Index U037216
Consensus CDS Project CCDS28274.1
International Mouse Phenotyping Consortium Status Nrip1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026674 VEGA Gene Model | MGI Sequence Detail 86428 C57BL/6J ±  kb
transcript OTTMUST00000066005 VEGA | MGI Sequence Detail 4529 Not Applicable 
polypeptide OTTMUSP00000032983 VEGA | MGI Sequence Detail 1161 Not Applicable 

For the selected sequences
All sequences(58) RefSeq(10) UniProt(1)
Polymorphisms
SNPs within 2kb(523 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR026649 Nuclear receptor-interacting protein 1
Protein Ontology PR:000011427 nuclear receptor-interacting protein 1
References
(Earliest) J:46180 Katsanis N, et al., Localisation of receptor interacting protein 140 (RIP140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome. Hum Genet. 1998 Feb;102(2):221-3
(Latest) J:211324 Lapierre M, et al., RIP140 increases APC expression and controls intestinal homeostasis and tumorigenesis. J Clin Invest. 2014 May 1;124(5):1899-913
All references(79)
Other
accession IDs
MGI:1918801, MGI:1925132, MGI:2146368, MGI:2146638

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/25/2015
MGI 6.0
The Jackson Laboratory