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Nrip1 Gene Detail
Summary
  • Symbol
    Nrip1
  • Name
    nuclear receptor interacting protein 1
  • Synonyms
    6030458L20Rik, 8430438I05Rik, RIP140
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315213
    NCBI Gene: 268903
  • Gene Overview
    MyGene.info: NRIP1
Location & Maps
more
  • Sequence Map
    Chr16:76287400-76373827 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      86428 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 43.65 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    NRIP1, nuclear receptor interacting protein 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    NRIP1, nuclear receptor interacting protein 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    RIP140
  • Links
    NCBI Gene ID: 8204
    neXtProt AC: NX_P48552

  • Chr Location
    21q11.2; chr21:14961235-15065903 (-)  GRCh38.p2

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    11 phenotypes from 1 allele in 2 genetic backgrounds
    20 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    164
  • Gene trapped
    157
  • Targeted
    6
  • Transgenic
    1
  • Genomic Mutations
    4 involving Nrip1
  • Incidental Mutations
Homozygosity for targeted disruption of this gene results in female infertility due to ovulation failure. Heterozygous females are partially affected. Male and female mice are smaller than wild-type littermates.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000026674 VEGA Gene Model | MGI Sequence Detail 86428 C57BL/6J ±  kb
transcript OTTMUST00000066003 VEGA | MGI Sequence Detail 7868 Not Applicable  
polypeptide OTTMUSP00000032982 VEGA | MGI Sequence Detail 1161 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    518 from dbSNP Build 142
Protein
Information
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  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000011427 nuclear receptor-interacting protein 1
  • InterPro Domains
    IPR026649 Nuclear receptor-interacting protein 1
    IPR031405 Nuclear receptor-interacting protein 1, repression domain 1
    IPR031406 Nuclear receptor-interacting protein 1, repression domain 2
    IPR031407 Nuclear receptor-interacting protein 1, repression domain 3
    IPR031408 Nuclear receptor-interacting protein 1, repression domain 4
Molecular
Reagents
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  • All nucleic 25
    cDNA 22
    Primer pair 2
    Other 1

    Microarray probesets 9
Other
Accession IDs
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MGI:1918801, MGI:1925132, MGI:2146368, MGI:2146638
References
more
  • Summaries
    All 80
    Developmental Gene Expression 14
    Diseases 1
    Gene Ontology 16
    Phenotypes 29
  • Earliest
    J:46180 Katsanis N, et al., Localisation of receptor interacting protein 140 (RIP140) within 100 kb of D21S13 on 21q11, a gene-poor region of the human genome. Hum Genet. 1998 Feb;102(2):221-3
  • Latest
    J:224980 Lee KY, et al., Tbx15 controls skeletal muscle fibre-type determination and muscle metabolism. Nat Commun. 2015;6:8054

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory