About   Help   FAQ
Slit1 Gene Detail
Summary
  • Symbol
    Slit1
  • Name
    slit guidance ligand 1
  • Synonyms
    mKIAA0813, Slil1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315203
    NCBI Gene: 20562
  • Gene Overview
    MyGene.info: SLIT1
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:41600257-41743665 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 19, 34.99 cM
Strain
Comparison
more
  • SNPs within 2kb
    1230 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1315203
protein coding gene Chr19:41597824-41747540 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025126
protein coding gene Chr19:40876002-41030521 (-)
A/J MGP_AJ_G0025103
protein coding gene Chr19:38907916-39054608 (-)
AKR/J MGP_AKRJ_G0025071
protein coding gene Chr19:40196662-40342001 (-)
BALB/cJ MGP_BALBcJ_G0025097
protein coding gene Chr19:38973204-39118552 (-)
C3H/HeJ MGP_C3HHeJ_G0024857
protein coding gene Chr19:40338553-40495835 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025541
protein coding gene Chr19:41963133-42116897 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022954
protein coding gene Chr19:38273163-38416555 (-)
CAST/EiJ MGP_CASTEiJ_G0024322
protein coding gene Chr19:40003208-40157057 (-)
CBA/J MGP_CBAJ_G0024837
protein coding gene Chr19:43990509-44152005 (-)
DBA/2J MGP_DBA2J_G0024969
protein coding gene Chr19:38765089-38909204 (-)
FVB/NJ MGP_FVBNJ_G0024930
protein coding gene Chr19:38531358-38683605 (-)
LP/J MGP_LPJ_G0025055
protein coding gene Chr19:40876768-41025383 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024961
protein coding gene Chr19:43640295-43791823 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025598
protein coding gene Chr19:40235388-40382009 (-)
PWK/PhJ MGP_PWKPhJ_G0024072
protein coding gene Chr19:38638045-38785128 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023875
protein coding gene Chr19:38968474-39123019 (-)
WSB/EiJ MGP_WSBEiJ_G0024392
protein coding gene Chr19:40384794-40533114 (-)



Homology
more
  • Human Ortholog
    SLIT1, slit guidance ligand 1
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLIT1, slit guidance ligand 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MEGF4, SLIL1, SLIT-1, SLIT3
  • Links
    NCBI Gene ID: 6585
    neXtProt AC: NX_O75093
    UniProt: O75093

  • Chr Location
    10q24.1; chr10:96998038-97185926 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    51 phenotype references
Mice homozygous for a reporter allele exhibit normal interneuron numbers and morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000025020 Ensembl Gene Model | MGI Sequence Detail 143409 C57BL/6J ±  kb
transcript ENSMUST00000025993 Ensembl | MGI Sequence Detail 5045 Not Applicable  
polypeptide ENSMUSP00000025993 Ensembl | MGI Sequence Detail 1531 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    cDNA 10
    Primer pair 3
    Other 4

    Microarray probesets 3
References
more
  • Summaries
    All 153
    Developmental Gene Expression 97
    Gene Ontology 14
    Phenotypes 51
  • Earliest
    J:56938 Yuan W, et al., The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Dev Biol. 1999 Aug 15;212(2):290-306
  • Latest
    J:264379 Cardenas A, et al., Evolution of Cortical Neurogenesis in Amniotes Controlled by Robo Signaling Levels. Cell. 2018 Jul 26;174(3):590-606.e21

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
11/06/2018
MGI 6.13
The Jackson Laboratory