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Slit1
Gene Detail
Symbol

Name
ID
Slit1
slit homolog 1 (Drosophila)
MGI:1315203
Synonyms
mKIAA0813, Slil1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
34.99 cM
Detailed Genetic Map ± 1 cM

Sequence Map
Chr19:41600257-41743665 bp, - strand
From VEGA annotation of GRCm38

  143409 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2302  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: slit protein
Gene Tree: Slit1

Human
homologs
Human Homolog SLIT1, slit homolog 1 (Drosophila)
NCBI Gene ID 6585
neXtProt AC  NX_O75093
Human Synonyms  MEGF4, SLIL1, SLIT-1, SLIT3
Human Chr (Location)  10q23.3-q24; chr10:96998038-97185926 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Gene trapped(2) Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a reporter allele exhibit normal interneuron numbers and morphology.
 
Interactions
Slit1 interacts with 178 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process axon extension involved in axon guidance, axon guidance, ...
Component cell, extracellular region, ...
Function calcium ion binding, heparan sulfate proteoglycan binding, ...
External Resources: FuncBase
Expression
Literature Summary: (70 records)
Data Summary: Results (121)    Tissues (90)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 121
cDNA source data(31)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(37) cDNA(33) Primer pair(1) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000036377 (Evidence)
Ensembl Gene ModelENSMUSG00000025020 (Evidence)
Entrez Gene20562 (Evidence)
UniGene40322
DFCITC1596756, TC1597045
DoTSDT.97359469, DT.60101791
NIA Mouse Gene IndexU039038
Consensus CDS ProjectCCDS29812.1
International Mouse Knockout Project StatusSlit1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036377 VEGA Gene Model | MGI Sequence Detail 143409 C57BL/6J ±  kb
transcript OTTMUST00000093267 VEGA | MGI Sequence Detail 5045 Not Applicable 
polypeptide OTTMUSP00000051703 VEGA | MGI Sequence Detail 1531 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(7)
Polymorphisms
SNPs within 2kb(1236 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR003645 Follistatin-like, N-terminal
InterPro IPR001791 Laminin G domain
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000015234 slit homolog 1 protein
References
(Earliest) J:56938 Yuan W, et al., The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Dev Biol. 1999 Aug 15;212(2):290-306
(Latest) J:213620 Kong P, et al., Tbx1 is required autonomously for cell survival and fate in the pharyngeal core mesoderm to form the muscles of mastication. Hum Mol Genet. 2014 Aug 15;23(16):4215-31
All references(124)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory