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Slit1
Gene Detail
Symbol

Name
ID
Slit1
slit homolog 1 (Drosophila)
MGI:1315203
Synonyms
mKIAA0813, Slil1
Feature Type
protein coding gene
Genetic Map
Chromosome 19
34.99 cM
Detailed Genetic Map ± 1 cM

Sequence Map
Chr19:41600257-41743665 bp, - strand
From VEGA annotation of GRCm38

  143409 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2302  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLIT1
Protein SuperFamily: slit protein
Gene Tree: Slit1

Human
homologs
SLIT1, slit guidance ligand 1
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 6585
neXtProt AC: NX_O75093

Human Synonyms: MEGF4, SLIL1, SLIT-1, SLIT3

Human Chr (Location): 10q23.3-q24; chr10:96998038-97185926 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(2) Targeted(5)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a reporter allele exhibit normal interneuron numbers and morphology.
 
Interactions
Slit1 interacts with 177 markers (Mir7-1, Mir15a, Mir15b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process axon extension involved in axon guidance, axon guidance, ...
Component cell, extracellular region, ...
Function calcium ion binding, heparan sulfate proteoglycan binding, ...
External Resources: FuncBase
Expression
Literature Summary: (75 records)
Data Summary: Results (121)    Tissues (90)    Images (56)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 121
cDNA source data(7)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA SLIT1 ; Xenbase slit1 ; ZFIN slit1a, slit1b    NEW 
Molecular
reagents
All nucleic(13) cDNA(9) Primer pair(1) Other(3)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000036377 (Evidence)
Ensembl Gene Model ENSMUSG00000025020 (Evidence)
Entrez Gene 20562 (Evidence)
DFCI TC1596756, TC1597045, TC1608709
DoTS DT.60101791, DT.94141271, DT.97359469
NIA Mouse Gene Index U039037, U039038
Consensus CDS Project CCDS29812.1
International Mouse Phenotyping Consortium Status Slit1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036377 VEGA Gene Model | MGI Sequence Detail 143409 C57BL/6J ±  kb
transcript OTTMUST00000093267 VEGA | MGI Sequence Detail 5045 Not Applicable 
polypeptide OTTMUSP00000051703 VEGA | MGI Sequence Detail 1531 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(4) UniProt(4)
Polymorphisms
SNPs within 2kb(1236 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase domain
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR001881 EGF-like calcium-binding domain
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000742 EGF-like domain
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR003645 Follistatin-like, N-terminal
InterPro IPR001791 Laminin G domain
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat N-terminal domain
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000015234 slit homolog 1 protein
References
(Earliest) J:56938 Yuan W, et al., The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance. Dev Biol. 1999 Aug 15;212(2):290-306
(Latest) J:221657 Kong JH, et al., Notch activity modulates the responsiveness of neural progenitors to sonic hedgehog signaling. Dev Cell. 2015 May 26;33(4):373-87
All references(128)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory