Slit3
Gene Detail

Symbol Name ID

Slit3 slit homolog 3 (Drosophila) MGI:1315202

Synonyms

Slit1

Feature Type

protein coding gene

Genetic Map

Chromosome 11

20.29 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr11:35121224-35708507 bp, + strand From VEGA annotation of GRCm38   587284 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2303  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: slit protein
Gene Tree: Slit3

Human homologs

Human Homolog		SLIT3, slit homolog 3 (Drosophila)
NCBI Gene ID		6586
neXtProt AC		NX_O75094
Human Synonyms		MEGF5, SLIL2, SLIT1, slit2, Slit-3
Human Chr (Location)		5q35; chr5:168093071-168728133 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(31) : Targeted(3) Gene trapped(28)
 

Mice homozygous for a gene trap allele show congenital diaphragmatic hernia (CDH), variable renal defects and enlarged heart right ventricles. Mice homozygous for either of two reporter alleles show diaphragm dysgenesis and die prematurely; those with end-stage CDH show dyspnea and lung congestion.

 
Human Diseases Modeled Using Mouse Slit3 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(2)

Gene Ontology (GO) classifications

All GO classifications: (22 annotations)

Process	axon extension involved in axon guidance, axon guidance, ...
Component	extracellular region, extracellular space, ...
Function	calcium ion binding, receptor binding, ...

External Resources: FuncBase

Expression

Literature Summary: (42 records)
Data Summary: Results (172)    Tissues (130)    Images (45)
Theiler Stages: 13, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
Immunohistochemistry	14
RNA in situ	125
Northern blot	9
RT-PCR	24

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(21) cDNA(16) Primer pair(4) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000005411 (Evidence)
Ensembl Gene Model	ENSMUSG00000056427 (Evidence)
Entrez Gene	20564 (Evidence)
DFCI	TC1585151, TC1621873, TC1624988, TC1633147, TC1762090
DoTS	DT.101705452, DT.482187, DT.97374233
NIA Mouse Gene Index	U012454
Consensus CDS Project	CCDS24542.1
International Mouse Knockout Project Status	Slit3

Sequences

Length	Strain/Species
genomic	OTTMUSG00000005411	VEGA Gene Model | MGI Sequence Detail	587284	C57BL/6J
transcript	OTTMUST00000012061	VEGA | MGI Sequence Detail	5228	Not Applicable
polypeptide	OTTMUSP00000005590	VEGA | MGI Sequence Detail	1523	Not Applicable

All sequences(41) RefSeq(2) UniProt(5)

Polymorphisms

SNPs(3193 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR008985	Concanavalin A-like lectin/glucanases superfamily
InterPro	IPR013320	Concanavalin A-like lectin/glucanase, subgroup
InterPro	IPR000483	Cysteine-rich flanking region, C-terminal
InterPro	IPR006207	Cystine knot, C-terminal
InterPro	IPR001881	EGF-like calcium-binding
InterPro	IPR018097	EGF-like calcium-binding, conserved site
InterPro	IPR013032	EGF-like, conserved site
InterPro	IPR000152	EGF-type aspartate/asparagine hydroxylation site
InterPro	IPR000742	Epidermal growth factor-like domain
InterPro	IPR001791	Laminin G domain
InterPro	IPR001611	Leucine-rich repeat
InterPro	IPR000372	Leucine-rich repeat-containing N-terminal
InterPro	IPR003591	Leucine-rich repeat, typical subtype
Protein Ontology	PR:000015236	slit 3 protein

References

(Earliest) J:52200 Holmes GP, et al., Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis. Mech Dev. 1998 Dec;79(1-2):57-72
(Latest) J:193400 Domyan ET, et al., Roundabout receptors are critical for foregut separation from the body wall. Dev Cell. 2013 Jan 14;24(1):52-63
All references(84)