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Slit3 Gene Detail
Summary
  • Symbol
    Slit3
  • Name
    slit guidance ligand 3
  • Synonyms
    b2b2362.1Clo, Slit1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315202
    NCBI Gene: 20564
  • Gene Overview
    MyGene.info: SLIT3
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr11:35121224-35708507 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      587284 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 11, 20.29 cM, cytoband A5
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    SLIT3, slit guidance ligand 3
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SLIT3, slit guidance ligand 3
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MEGF5, SLIL2, SLIT1, slit2, Slit-3
  • Links
    NCBI Gene ID: 6586
    neXtProt AC: NX_O75094
    UniProt: O75094

  • Chr Location
    5q34-q35.1; chr5:168661733-169301129 (-)  GRCh38.p7

Human Diseases
more
  • Diseases
    1 with Slit3 mouse models

Human Disease Mouse Models
      
IDs
View 4 models
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    3 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    26 phenotypes from 4 alleles in 4 genetic backgrounds
    6 phenotypes from multigenic genotypes
    14 images
    32 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele show congenital diaphragmatic hernia (CDH), variable renal defects and enlarged heart right ventricles. Mice homozygous for either of two reporter alleles show diaphragm dysgenesis and die prematurely; those with end-stage CDH show dyspnea and lung congestion.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000005411 VEGA Gene Model | MGI Sequence Detail 587284 C57BL/6J ±  kb
    transcript OTTMUST00000012061 VEGA | MGI Sequence Detail 5228 Not Applicable  
    polypeptide OTTMUSP00000005590 VEGA | MGI Sequence Detail 1523 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      4492 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 24
      cDNA 16
      Primer pair 5
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:5560151
    References
    more
    • Summaries
      All 105
      Developmental Gene Expression 55
      Diseases 3
      Gene Ontology 10
      Phenotypes 32
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:253971 Dominici C, et al., Non-cell autonomous control of precerebellar neuron migration by Slit and Robo proteins. Development. 2018 Jan 17;145(2):None

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    06/05/2018
    MGI 6.12
    The Jackson Laboratory