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Slit3
Gene Detail
Symbol

Name
ID
Slit3
slit homolog 3 (Drosophila)
MGI:1315202
Synonyms
b2b2362.1Clo, Slit1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
20.29 cM, cytoband A5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:35121224-35708507 bp, + strand
From VEGA annotation of GRCm38

  587284 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2303  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLIT3
Protein SuperFamily: slit protein
Gene Tree: Slit3

Human
homologs
SLIT3, slit guidance ligand 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6586
neXtProt AC: NX_O75094

Human Synonyms: MEGF5, SLIL2, SLIT1, slit2, Slit-3

Human Chr (Location): 5q35; chr5:168661733-169301129 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Chemically induced (ENU)(1) Gene trapped(28) Targeted(3)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a gene trap allele show congenital diaphragmatic hernia (CDH), variable renal defects and enlarged heart right ventricles. Mice homozygous for either of two reporter alleles show diaphragm dysgenesis and die prematurely; those with end-stage CDH show dyspnea and lung congestion.
 
Human Diseases Modeled in Mice Using Slit3 (1)    Mutations Annotated to Human Diseases (3)    Phenotype Images(10)
Interactions
Slit3 interacts with 116 markers (Mir7-1, Mir22, Mir25, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process axon extension involved in axon guidance, axon guidance, ...
Component extracellular region, extracellular space, ...
Function calcium ion binding, receptor binding, ...
External Resources: FuncBase
Expression
Literature Summary: (49 records)
Data Summary: Results (265)    Tissues (191)    Images (89)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 19
RNA in situ 213
Northern blot 9
RT-PCR 24
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA SLIT3 ; Xenbase slit3 ; ZFIN slit3    NEW 
Molecular
reagents
All nucleic(22) cDNA(16) Primer pair(4) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000005411 (Evidence)
Ensembl Gene Model ENSMUSG00000056427 (Evidence)
Entrez Gene 20564 (Evidence)
DFCI TC1621873, TC1585151, TC1762090, TC1633147, TC1624988
DoTS DT.97374233, DT.482187, DT.101705452
NIA Mouse Gene Index U012454
Consensus CDS Project CCDS24542.1
International Mouse Phenotyping Consortium Status Slit3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005411 VEGA Gene Model | MGI Sequence Detail 587284 C57BL/6J ±  kb
transcript OTTMUST00000012061 VEGA | MGI Sequence Detail 5228 Not Applicable 
polypeptide OTTMUSP00000005590 VEGA | MGI Sequence Detail 1523 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(5)
Polymorphisms
SNPs within 2kb(4534 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4536)
Protein-related
information
ResourceIDDescription
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001791 Laminin G domain
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000015236 slit homolog 3 protein
References
(Earliest) J:52200 Holmes GP, et al., Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis. Mech Dev. 1998 Dec;79(1-2):57-72
(Latest) J:221341 Lun MP, et al., Spatially heterogeneous choroid plexus transcriptomes encode positional identity and contribute to regional CSF production. J Neurosci. 2015 Mar 25;35(12):4903-16
All references(94)
Disease annotation references (3)
Other
accession IDs
MGI:5560151

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory