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Gene Detail
slit homolog 3 (Drosophila)
Synonyms Slit1
Feature Type protein coding gene
Genetic Map
Chromosome 11
20.29 cM, cytoband A5
Detailed Genetic Map ± 1 cM

Mapping data(3)
Sequence Map
Chr11:35121224-35708507 bp, + strand
From VEGA annotation of GRCm38

  587284 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser
HomoloGene:2303  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: slit protein
Gene Tree: Slit3

Human Homolog SLIT3, slit homolog 3 (Drosophila)
NCBI Gene ID 6586
neXtProt AC  NX_O75094
Human Synonyms  MEGF5, SLIL2, SLIT1, slit2, Slit-3
Human Chr (Location)  5q35; chr5:168661733-169301129 (-)  GRCh38
alleles, and
All mutations/alleles(31) : Gene trapped(28) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Mice homozygous for a gene trap allele show congenital diaphragmatic hernia (CDH), variable renal defects and enlarged heart right ventricles. Mice homozygous for either of two reporter alleles show diaphragm dysgenesis and die prematurely; those with end-stage CDH show dyspnea and lung congestion.
Human Diseases Modeled Using Mouse Slit3 (1)    Alleles Annotated to Human Diseases(3)    Phenotype Images(2)
Slit3 interacts with 116 markers (Mir7-1, Mir22, Mir25, ...)
Gene Ontology
All GO classifications: (22 annotations)
Process axon extension involved in axon guidance, axon guidance, ...
Component extracellular region, extracellular space, ...
Function calcium ion binding, receptor binding, ...
External Resources: FuncBase
Literature Summary: (45 records)
Data Summary: Results (265)    Tissues (191)    Images (89)
Theiler Stages: 11, 12, 13, 14, 15, 16, 17, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28
Assay TypeResults
Immunohistochemistry 19
RNA in situ 213
Northern blot 9
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
All nucleic(22) cDNA(16) Primer pair(4) Other(2)
Microarray probesets(4)
Other database
VEGA Gene ModelOTTMUSG00000005411 (Evidence)
Ensembl Gene ModelENSMUSG00000056427 (Evidence)
Entrez Gene20564 (Evidence)
DFCITC1585151, TC1621873, TC1624988, TC1633147, TC1762090
DoTSDT.101705452, DT.482187, DT.97374233
NIA Mouse Gene IndexU012454
Consensus CDS ProjectCCDS24542.1
International Mouse Knockout Project StatusSlit3
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000005411 VEGA Gene Model | MGI Sequence Detail 587284 C57BL/6J ±  kb
transcript OTTMUST00000012061 VEGA | MGI Sequence Detail 5228 Not Applicable 
polypeptide OTTMUSP00000005590 VEGA | MGI Sequence Detail 1523 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(4534 from dbSNP Build 137)    SNPs within 2kb including multiple locations(4536)
InterPro IPR008985 Concanavalin A-like lectin/glucanases superfamily
InterPro IPR013320 Concanavalin A-like lectin/glucanase, subgroup
InterPro IPR000483 Cysteine-rich flanking region, C-terminal
InterPro IPR006207 Cystine knot, C-terminal
InterPro IPR001881 EGF-like calcium-binding
InterPro IPR018097 EGF-like calcium-binding, conserved site
InterPro IPR013032 EGF-like, conserved site
InterPro IPR000152 EGF-type aspartate/asparagine hydroxylation site
InterPro IPR000742 Epidermal growth factor-like domain
InterPro IPR009030 Insulin-like growth factor binding protein, N-terminal
InterPro IPR001791 Laminin G domain
InterPro IPR001611 Leucine-rich repeat
InterPro IPR000372 Leucine-rich repeat-containing N-terminal
InterPro IPR003591 Leucine-rich repeat, typical subtype
Protein Ontology PR:000015236 slit homolog 3 protein
References (Earliest) J:52200 Holmes GP, et al., Distinct but overlapping expression patterns of two vertebrate slit homologs implies functional roles in CNS development and organogenesis. Mech Dev. 1998 Dec;79(1-2):57-72
(Latest) J:210623 Yeh ML, et al., Robo1 modulates proliferation and neurogenesis in the developing neocortex. J Neurosci. 2014 Apr 16;34(16):5717-31
All references(89)
Disease annotation references (3)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
MGI 5.19
The Jackson Laboratory