About   Help   FAQ
Spsb2 Gene Detail
Summary
  • Symbol
    Spsb2
  • Name
    splA/ryanodine receptor domain and SOCS box containing 2
  • Synonyms
    Grcc9, SSB2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315199
    NCBI Gene: 14794
  • Alliance
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124808661-124810619 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    18 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1315199
protein coding gene Chr6:124808574-124810619 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031268
protein coding gene Chr6:128115448-128117406 (+)
A/J MGP_AJ_G0031238
protein coding gene Chr6:123293969-123295927 (+)
AKR/J MGP_AKRJ_G0031166
protein coding gene Chr6:126658442-126660400 (+)
BALB/cJ MGP_BALBcJ_G0031246
protein coding gene Chr6:122894538-122896541 (+)
C3H/HeJ MGP_C3HHeJ_G0030969
protein coding gene Chr6:126705134-126707092 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031702
protein coding gene Chr6:131499133-131501099 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028852
protein coding gene Chr6:120504948-120506918 (+)
CAST/EiJ MGP_CASTEiJ_G0030350
protein coding gene Chr6:126908608-126910565 (+)
CBA/J MGP_CBAJ_G0030930
protein coding gene Chr6:136529466-136531424 (+)
DBA/2J MGP_DBA2J_G0031086
protein coding gene Chr6:122220823-122223508 (+)
FVB/NJ MGP_FVBNJ_G0031036
protein coding gene Chr6:121123554-121125512 (+)
LP/J MGP_LPJ_G0031166
protein coding gene Chr6:128285577-128287542 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031074
protein coding gene Chr6:140589751-140591709 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031737
protein coding gene Chr6:126552012-126553969 (+)
PWK/PhJ MGP_PWKPhJ_G0030065
protein coding gene Chr6:120449773-120451774 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029894
protein coding gene Chr6:124632130-124634087 (+)
WSB/EiJ MGP_WSBEiJ_G0030435
protein coding gene Chr6:126911989-126913945 (+)



Homology
more
  • Human Ortholog
    SPSB2, splA/ryanodine receptor domain and SOCS box containing 2
  • Vertebrate Orthologs
    5
  • Human Ortholog
    SPSB2, splA/ryanodine receptor domain and SOCS box containing 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GRCC9, SSB2
  • Links
    NCBI Gene ID: 84727
    neXtProt AC: NX_Q99619
    UniProt: Q99619

  • Chr Location
    12p13.31; chr12:6870935-6873357 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    23 phenotypes from multigenic genotypes
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit mild thrombocytopenia and decreased blood urea nitrogen levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000038451 Ensembl Gene Model | MGI Sequence Detail 1959 C57BL/6J ±  kb
transcript ENSMUST00000047760 Ensembl | MGI Sequence Detail 1213 Not Applicable  
polypeptide ENSMUSP00000041585 Ensembl | MGI Sequence Detail 264 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 43
    Genomic 1
    cDNA 42

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141421
References
more
  • Summaries
    All 37
    Diseases 1
    Gene Ontology 8
    Phenotypes 11
  • Earliest
    J:45711 Ansari-Lari MA, et al., Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6. Genome Res. 1998 Jan;8(1):29-40
  • Latest
    J:256501 Ozdemir AC, et al., GNB3 overexpression causes obesity and metabolic syndrome. PLoS One. 2017;12(12):e0188763

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
03/13/2019
MGI 6.13
The Jackson Laboratory