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Hk2 Gene Detail
Summary
  • Symbol
    Hk2
  • Name
    hexokinase 2
  • Synonyms
    HKII
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315197
    NCBI Gene: 15277
  • Gene Overview
    MyGene.info: HK2
Location & Maps
more
  • Sequence Map
    Chr6:82725025-82774454 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      49430 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    HK2, hexokinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HK2, hexokinase 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HKII, HXK2
  • Links
    NCBI Gene ID: 3099
    neXtProt AC: NX_P52789

  • Chr Location
    2p13; chr2:74832655-74893354 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Hk2 mouse models

Human Disease Mouse Models
       Diabetes Mellitus, Insulin-Dependent, 2   OMIM: 125852
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    57
  • Gene trapped
    52
  • Spontaneous
    1
  • Targeted
    4
  • Genomic Mutations
    1 involving Hk2
  • Incidental Mutations
Embryos homozygous for a knock-out mutation are severely growth retarded and die around E8.5. Interestingly, heterozygous mutant mice are viable and fertile, develop normally and do not exhibit impaired insulin action or glucose tolerance even when challenged with a high-fat diet.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035991 VEGA Gene Model | MGI Sequence Detail 49430 C57BL/6J ±  kb
transcript OTTMUST00000092356 VEGA | MGI Sequence Detail 5513 Not Applicable  
polypeptide OTTMUSP00000051023 VEGA | MGI Sequence Detail 917 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    403 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 17
    Genomic 5
    cDNA 10
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGI:2141455
References
more
  • Summaries
    All 63
    Developmental Gene Expression 12
    Diseases 1
    Gene Ontology 13
    Phenotypes 16
  • Earliest
    J:34217 Tsao TS, et al., Regulation of hexokinase II gene expression by glucose flux in skeletal muscle. J Biol Chem. 1996 Jun 21;271(25):14959-63
  • Latest
    J:227211 Zhang Y, et al., Maternal bile acid transporter deficiency promotes neonatal demise. Nat Commun. 2015;6:8186

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory