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Hk2 Gene Detail
Summary
  • Symbol
    Hk2
  • Name
    hexokinase 2
  • Synonyms
    HKII
  • Feature Type
    protein coding gene
  • IDs
    MGI:1315197
    NCBI Gene: 15277
  • Gene Overview
    MyGene.info: HK2
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:82725025-82774454 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 35.94 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    403 from dbSNP Build 142
  • Strain Annotations
    13
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1315197
protein coding gene Chr6:82725023-82774454 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030906
protein coding gene Chr6:83704653-83757454 (-)
A/J MGP_AJ_G0030875
protein coding gene Chr6:80510473-80559689 (-)
AKR/J no annotation
BALB/cJ MGP_BALBcJ_G0030885
protein coding gene Chr6:80524241-80573688 (-)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0031345
protein coding gene Chr6:85971729-86023093 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028531
protein coding gene Chr6:78864989-78913663 (-)
CAST/EiJ MGP_CASTEiJ_G0029994
protein coding gene Chr6:82804308-82866630 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0030725
protein coding gene Chr6:79832084-79880521 (-)
FVB/NJ no annotation
LP/J no annotation
NOD/ShiLtJ MGP_NODShiLtJ_G0030714
protein coding gene Chr6:93694877-93750290 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031369
protein coding gene Chr6:82635159-82687974 (-)
PWK/PhJ MGP_PWKPhJ_G0029709
protein coding gene Chr6:78717430-78767607 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029537
protein coding gene Chr6:81499194-81548462 (-)
WSB/EiJ MGP_WSBEiJ_G0030075
protein coding gene Chr6:83078910-83128057 (-)



Homology
more
  • Human Ortholog
    HK2, hexokinase 2
  • Vertebrate Orthologs
    10
  • Human Ortholog
    HK2, hexokinase 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HKII, HXK2
  • Links
    NCBI Gene ID: 3099
    neXtProt AC: NX_P52789
    UniProt: P52789

  • Chr Location
    2p12; chr2:74832655-74893354 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 2 alleles in 3 genetic backgrounds
    6 phenotypes from multigenic genotypes
    1 images
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Embryos homozygous for a knock-out mutation are severely growth retarded and die around E8.5. Interestingly, heterozygous mutant mice are viable and fertile, develop normally and do not exhibit impaired insulin action or glucose tolerance even when challenged with a high-fat diet.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000000628 Ensembl Gene Model | MGI Sequence Detail 49430 C57BL/6J ±  kb
    transcript ENSMUST00000000642 Ensembl | MGI Sequence Detail 5513 Not Applicable  
    polypeptide ENSMUSP00000000642 Ensembl | MGI Sequence Detail 917 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 5
      cDNA 11
      Primer pair 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2141455
    References
    more
    • Summaries
      All 81
      Developmental Gene Expression 15
      Diseases 1
      Gene Ontology 15
      Phenotypes 17
    • Earliest
      J:34217 Tsao TS, et al., Regulation of hexokinase II gene expression by glucose flux in skeletal muscle. J Biol Chem. 1996 Jun 21;271(25):14959-63
    • Latest
      J:258996 Tan H, et al., Integrative Proteomics and Phosphoproteomics Profiling Reveals Dynamic Signaling Networks and Bioenergetics Pathways Underlying T Cell Activation. Immunity. 2017 Mar 21;46(3):488-503

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory