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Hk2
Gene Detail
Symbol

Name
ID
Hk2
hexokinase 2
MGI:1315197
Synonyms
HKII
Feature Type
protein coding gene
Genetic Map
Chromosome 6
35.94 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:82725025-82774454 bp, - strand
From VEGA annotation of GRCm38

  49430 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37273  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: HK2
Protein SuperFamily: hexokinase I
Gene Tree: Hk2

Human
homologs
HK2, hexokinase 2
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 3099
neXtProt AC: NX_P52789

Human Synonyms: HKII, HXK2

Human Chr (Location): 2p13; chr2:74832655-74893354 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(57) : Gene trapped(52) Spontaneous(1) Targeted(4)
Genomic Mutations involving Hk2 (1)
Incidental mutations (data from Mutagenetix , APF )
 
Embryos homozygous for a knock-out mutation are severely growth retarded and die around E8.5. Interestingly, heterozygous mutant mice are viable and fertile, develop normally and do not exhibit impaired insulin action or glucose tolerance even when challenged with a high-fat diet.
 
Phenotype Images(1)
Interactions
Hk2 interacts with 248 markers (Mir7-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (32 annotations)
Process apoptotic mitochondrial changes, carbohydrate metabolic process, ...
Component cytosol, membrane, ...
Function ATP binding, catalytic activity, ...
External Resources: FuncBase
Expression
Literature Summary: (11 records)
Data Summary: Results (128)    Tissues (103)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 124
Western blot 2
RT-PCR 2
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA HK2 ; Xenbase hk2 ; ZFIN hk2    NEW 
Molecular
reagents
All nucleic(17) Genomic(5) cDNA(10) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000035991 (Evidence)
Ensembl Gene Model ENSMUSG00000000628 (Evidence)
Entrez Gene 15277 (Evidence)
DFCI TC1576951
DoTS DT.532616
NIA Mouse Gene Index U027512
EC 2.7.1.1
Consensus CDS Project CCDS20263.1
International Mouse Phenotyping Consortium Status Hk2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000035991 VEGA Gene Model | MGI Sequence Detail 49430 C57BL/6J ±  kb
transcript OTTMUST00000092356 VEGA | MGI Sequence Detail 5513 Not Applicable 
polypeptide OTTMUSP00000051023 VEGA | MGI Sequence Detail 917 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(3)
Polymorphisms
RFLP(1) : SNPs within 2kb(405 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001312 Hexokinase
InterPro IPR019807 Hexokinase, conserved site
InterPro IPR022673 Hexokinase, C-terminal
InterPro IPR022672 Hexokinase, N-terminal
Protein Ontology PR:000008609 hexokinase-2
References
(Earliest) J:34217 Tsao TS, et al., Regulation of hexokinase II gene expression by glucose flux in skeletal muscle. J Biol Chem. 1996 Jun 21;271(25):14959-63
(Latest) J:213639 Smith JA, et al., Renal cortical hexokinase and pentose phosphate pathway activation through the EGFR/Akt signaling pathway in endotoxin-induced acute kidney injury. Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F435-44
All references(64)
Disease annotation references (1)
Other
accession IDs
MGI:2141455

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/23/2015
MGI 5.22
The Jackson Laboratory