Tnfrsf11a
Gene Detail

Symbol Name ID

Tnfrsf11a tumor necrosis factor receptor superfamily, member 11a MGI:1314891

Synonyms

Rank, TRANCE-R

Feature Type

protein coding gene

Genetic Map

Chromosome 1

49.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr1:105780723-105847981 bp, + strand From NCBI annotation of GRCm38   67259 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2848  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tumor necrosis factor receptor superfamily member 11A
Gene Tree: Tnfrsf11a

Human homologs

Human Homolog		TNFRSF11A, tumor necrosis factor receptor superfamily, member 11a, NFKB activator
NCBI Gene ID		8792
neXtProt AC		NX_Q9Y6Q6
Human Synonyms		CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER
Human Chr (Location)		18q22.1; chr18:59992520-60054943 (+)  GRCh37.p10
Disease Associations		(3) Diseases Associated with Human TNFRSF11A

Alleles and phenotypes

All alleles(7) : Targeted(6) Spontaneous(1)
 

Mice homozygous for a knock-out or spontaneous allele exhibit a failure of tooth eruption, osteopetrosis, and abnormal immune system morphology.

 

Gene Ontology (GO) classifications

All GO classifications: (28 annotations)

Process	adaptive immune response, circadian temperature homeostasis, ...
Component	cell surface, external side of plasma membrane, ...
Function	cytokine binding, metal ion binding, ...

External Resources: FuncBase

Expression

Literature Summary: (8 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23

Assay Type	Results
RNA in situ	24

cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(14) cDNA(14)
Microarray probesets(4)

Other database links

Ensembl Gene Model	ENSMUSG00000026321 (Evidence)
Entrez Gene	21934 (Evidence)
UniGene	6251
DFCI	TC1587930, TC1630085, TC1660593
DoTS	DT.525842, DT.91336672, DT.91590170, DT.97405701
NIA Mouse Gene Index	U000676
PDB	3QBQ, 4GIQ, 3ME2, 3ME4
Consensus CDS Project	CCDS15207.1
International Mouse Knockout Project Status	Tnfrsf11a

Sequences

Length	Strain/Species
genomic	21934	NCBI Gene Model | MGI Sequence Detail	67259	C57BL/6J
transcript	NM_009399	RefSeq | MGI Sequence Detail	5022	C57BL/6
polypeptide	O35305	UniProt | EBI | MGI Sequence Detail	625	Not Applicable

All sequences(20) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(212 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001368	TNFR/NGFR cysteine-rich region
InterPro	IPR022323	Tumour necrosis factor receptor 11
InterPro	IPR022361	Tumour necrosis factor receptor 11A
Protein Ontology	PR:000001954	tumor necrosis factor receptor superfamily member 11A

Graphical View of Protein Domain Structure

References

(Earliest) J:44239 Anderson DM, et al., A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature. 1997 Nov 13;390(6656):175-9
(Latest) J:190854 Desanti GE, et al., Developmentally Regulated Availability of RANKL and CD40 Ligand Reveals Distinct Mechanisms of Fetal and Adult Cross-Talk in the Thymus Medulla. J Immunol. 2012 Dec 15;189(12):5519-26
All references(73)

Other accession IDs

MGI:1194917