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Tnfrsf11a
Gene Detail
Symbol

Name
ID
Tnfrsf11a
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
MGI:1314891
Synonyms
Rank, TRANCE-R
Feature Type
protein coding gene
Genetic Map
Chromosome 1
49.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:105780718-105847981 bp, + strand
From VEGA annotation of GRCm38

  67264 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2848  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

Protein SuperFamily: tumor necrosis factor receptor superfamily member 11A
Gene Tree: Tnfrsf11a

Human
homologs
Human Homolog TNFRSF11A, tumor necrosis factor receptor superfamily, member 11a, NFKB activator
NCBI Gene ID 8792
neXtProt AC  NX_Q9Y6Q6
Human Synonyms  CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER
Human Chr (Location)  18q22.1; chr18:62325287-62387710 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human TNFRSF11A
Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Spontaneous(1) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out or spontaneous allele exhibit a failure of tooth eruption, osteopetrosis, and abnormal immune system morphology.
 
Interactions
Tnfrsf11a interacts with 286 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process adaptive immune response, circadian temperature homeostasis, ...
Component cell surface, external side of plasma membrane, ...
Function cytokine binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (24)    Tissues (15)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
cDNA source data(14)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000048968 (Evidence)
Ensembl Gene ModelENSMUSG00000026321 (Evidence)
Entrez Gene21934 (Evidence)
UniGene6251
DFCITC1660593, TC1630085, TC1587930
DoTSDT.525842, DT.91590170, DT.97405701, DT.91336672
NIA Mouse Gene IndexU000676
PDB3QBQ, 4GIQ, 3ME4, 3ME2
Consensus CDS ProjectCCDS15207.1
International Mouse Knockout Project StatusTnfrsf11a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048968 VEGA Gene Model | MGI Sequence Detail 67264 C57BL/6J ±  kb
transcript OTTMUST00000125109 VEGA | MGI Sequence Detail 5027 Not Applicable 
polypeptide OTTMUSP00000067911 VEGA | MGI Sequence Detail 625 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(423 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR022323 Tumour necrosis factor receptor 11
InterPro IPR022361 Tumour necrosis factor receptor 11A
Protein Ontology PR:000001954 tumor necrosis factor receptor superfamily member 11A
References
(Earliest) J:44239 Anderson DM, et al., A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature. 1997 Nov 13;390(6656):175-9
(Latest) J:211351 Shimamura M, et al., OPG/RANKL/RANK axis is a critical inflammatory signaling system in ischemic brain in mice. Proc Natl Acad Sci U S A. 2014 Jun 3;111(22):8191-6
All references(77)
Other
accession IDs
MGI:1194917

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/16/2014
MGI 5.20
The Jackson Laboratory