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Tnfrsf11a
Gene Detail
Symbol

Name
ID
Tnfrsf11a
tumor necrosis factor receptor superfamily, member 11a, NFKB activator
MGI:1314891
Synonyms
Rank, TRANCE-R
Feature Type
protein coding gene
Genetic Map
Chromosome 1
49.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:105780718-105847981 bp, + strand
From VEGA annotation of GRCm38

  67264 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2848  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog

HCOP human homology predictions: TNFRSF11A
Protein SuperFamily: tumor necrosis factor receptor superfamily member 11A
Gene Tree: Tnfrsf11a

Human
homologs
TNFRSF11A, tumor necrosis factor receptor superfamily, member 11a, NFKB activator
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 8792
neXtProt AC: NX_Q9Y6Q6

Human Synonyms: CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER

Human Chr (Location): 18q22.1; chr18:62325287-62387710 (+)  GRCh38.p2

Disease Associations: (3) Diseases Associated with Human TNFRSF11A

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Spontaneous(1) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out or spontaneous allele exhibit a failure of tooth eruption, osteopetrosis, and abnormal immune system morphology.
 
Interactions
Tnfrsf11a interacts with 286 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process adaptive immune response, circadian temperature homeostasis, ...
Component cell surface, external side of plasma membrane, ...
Function cytokine binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (26)    Tissues (17)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 2
RNA in situ 24
cDNA source data(14)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase tnfrsf11a    NEW 
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000048968 (Evidence)
Ensembl Gene Model ENSMUSG00000026321 (Evidence)
Entrez Gene 21934 (Evidence)
UniGene 6251
DFCI TC1587930, TC1630085, TC1660593
DoTS DT.97405701, DT.91590170, DT.91336672, DT.525842
NIA Mouse Gene Index U000676
PDB 4GIQ, 3QBQ, 3ME2, 3ME4
Consensus CDS Project CCDS15207.1
International Mouse Phenotyping Consortium Status Tnfrsf11a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000048968 VEGA Gene Model | MGI Sequence Detail 67264 C57BL/6J ±  kb
transcript OTTMUST00000125109 VEGA | MGI Sequence Detail 5027 Not Applicable 
polypeptide OTTMUSP00000067911 VEGA | MGI Sequence Detail 625 Not Applicable 

For the selected sequences
All sequences(29) RefSeq(4) UniProt(1)
Polymorphisms
SNPs within 2kb(423 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR022323 Tumour necrosis factor receptor 11
InterPro IPR022361 Tumour necrosis factor receptor 11A
Protein Ontology PR:000001954 tumor necrosis factor receptor superfamily member 11A
References
(Earliest) J:44239 Anderson DM, et al., A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature. 1997 Nov 13;390(6656):175-9
(Latest) J:219915 Powell JJ, et al., An endogenous nanomineral chaperones luminal antigen and peptidoglycan to intestinal immune cells. Nat Nanotechnol. 2015 May;10(4):361-9
All references(77)
Other
accession IDs
MGI:1194917

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory