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Tnfrsf11a
Gene Detail
 Symbol
Name
ID
Tnfrsf11a
tumor necrosis factor receptor superfamily, member 11a
MGI:1314891
Synonyms Rank, TRANCE-R
Feature Type protein coding gene
Genetic Map
Chromosome 1
49.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr1:105780723-105847981 bp, + strand
From NCBI annotation of GRCm38

  67259 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2848  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tumor necrosis factor receptor superfamily member 11A
Gene Tree: Tnfrsf11a

Human
homologs
Human Homolog TNFRSF11A, tumor necrosis factor receptor superfamily, member 11a, NFKB activator
NCBI Gene ID 8792
neXtProt AC  NX_Q9Y6Q6
Human Synonyms  CD265, FEO, LOH18CR1, ODFR, OFE, OPTB7, OSTS, PDB2, RANK, TRANCER
Human Chr (Location)  18q22.1; chr18:62325287-62387710 (+)  GRCh38
Disease Associations  (3) Diseases Associated with Human TNFRSF11A
Alleles
and
phenotypes
All alleles(7) : Targeted(6) Spontaneous(1)
 
Mice homozygous for a knock-out or spontaneous allele exhibit a failure of tooth eruption, osteopetrosis, and abnormal immune system morphology.
 
Gene Ontology
(GO)
classifications
All GO classifications: (30 annotations)
Process adaptive immune response, circadian temperature homeostasis, ...
Component cell surface, external side of plasma membrane, ...
Function cytokine binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (24)    Tissues (15)    Images (2)
Theiler Stages: 23
Assay TypeResults
RNA in situ 24
cDNA source data(14)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000026321 (Evidence)
Entrez Gene21934 (Evidence)
UniGene6251
DFCITC1587930, TC1630085, TC1660593
DoTSDT.525842, DT.91336672, DT.91590170, DT.97405701
NIA Mouse Gene IndexU000676
PDB3QBQ, 4GIQ, 3ME2, 3ME4
Consensus CDS ProjectCCDS15207.1
International Mouse Knockout Project StatusTnfrsf11a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 21934 NCBI Gene Model | MGI Sequence Detail 67259 C57BL/6J ±  kb
transcript NM_009399 RefSeq | MGI Sequence Detail 5022 C57BL/6 
polypeptide O35305 UniProt | EBI | MGI Sequence Detail 625 Not Applicable 

For the selected sequences
All sequences(22) RefSeq(4) UniProt(1)
Polymorphisms SNPs within 2kb(423 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR022323 Tumour necrosis factor receptor 11
InterPro IPR022361 Tumour necrosis factor receptor 11A
Protein Ontology PR:000001954 tumor necrosis factor receptor superfamily member 11A
Graphical View of Protein Domain Structure
References (Earliest) J:44239 Anderson DM, et al., A homologue of the TNF receptor and its ligand enhance T-cell growth and dendritic-cell function. Nature. 1997 Nov 13;390(6656):175-9
(Latest) J:196304 Kiechl S, et al., Blockade of receptor activator of nuclear factor-kappaB (RANKL) signaling improves hepatic insulin resistance and prevents development of diabetes mellitus. Nat Med. 2013 Mar;19(3):358-63
All references(74)
Other
accession IDs
MGI:1194917

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory