About   Help   FAQ
Tnfrsf1b Gene Detail
Summary
  • Symbol
    Tnfrsf1b
  • Name
    tumor necrosis factor receptor superfamily, member 1b
  • Synonyms
    CD120b, p75, p75 TNFR, TNF-alphaR2, TNFalpha-R2, TNFBR, Tnfr2, TNF-R2, TNF-R75, TNFR80, TNFRII, TNF-R-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314883
    NCBI Gene: 21938
  • Gene Overview
    MyGene.info: TNFRSF1B
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:145213463-145246870 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33408 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 78.17 cM
  • Mapping Data
    18 experiments
  • Sequence Tag
Homology
more
  • Human Ortholog
    TNFRSF1B, TNF receptor superfamily member 1B
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TNFRSF1B, TNF receptor superfamily member 1B
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD120b, p75, p75TNFR, TBPII, TNFBR, TNFR1B, TNFR2, TNF-R75, TNFR80, TNF-R-II
  • Links
    NCBI Gene ID: 7133
    neXtProt AC: NX_P20333
    UniProt: P20333

  • Chr Location
    1p36.22; chr1:12166948-12209222 (+)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 3 alleles in 8 genetic backgrounds
    59 phenotypes from multigenic genotypes
    358 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit altered inflammatory responses in a variety of experimental conditions, impaired recovery from spinal cord injury, enhanced ischemia-reperfusion-induced retinal damage, and resistance to cerebral malaria.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000010013 VEGA Gene Model | MGI Sequence Detail 33408 C57BL/6J ±  kb
    transcript OTTMUST00000023284 VEGA | MGI Sequence Detail 3818 Not Applicable  
    polypeptide OTTMUSP00000010647 VEGA | MGI Sequence Detail 474 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      348 from dbSNP Build 142
    • PCR
    • RFLP
    Protein
    Information
    less
    • UniProt
      5 Sequences
    • Protein Ontology
      PR:000001959 tumor necrosis factor receptor superfamily member 1B
    • InterPro Domains
      IPR001368 TNFR/NGFR cysteine-rich region
      IPR033996 Tumor necrosis factor receptor 1B, N-terminal
      IPR020411 Tumour necrosis factor receptor 1B
    Molecular
    Reagents
    less
    • All nucleic 67
      Genomic 3
      cDNA 58
      Primer pair 4
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15154, MGD-MRK-15157, MGI:98782
    References
    more
    • Summaries
      All 510
      Developmental Gene Expression 8
      Diseases 2
      Gene Ontology 12
      Phenotypes 358
    • Earliest
      J:399 Milatovich A, et al., Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. Somat Cell Mol Genet. 1991 Sep;17(5):519-23
    • Latest
      J:261826 Wang Y, et al., Notch-Tnf signalling is required for development and homeostasis of arterial valves. Eur Heart J. 2017 Mar 1;38(9):675-686

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    06/12/2018
    MGI 6.12
    The Jackson Laboratory