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Tnfrsf1b
Gene Detail
Symbol

Name
ID
Tnfrsf1b
tumor necrosis factor receptor superfamily, member 1b
MGI:1314883
STS
Synonyms
CD120b, p75, p75 TNFR, TNF-alphaR2, TNFalpha-R2, TNFBR, Tnfr2, TNF-R2, TNF-R75, TNFR80, TNFRII, TNF-R-II
Feature Type
protein coding gene
Genetic Map
Chromosome 4
78.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr4:145213463-145246870 bp, - strand
From VEGA annotation of GRCm38

  33408 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:829  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

HCOP human homology predictions: TNFRSF1B
Protein SuperFamily: tumor necrosis factor receptor type 2
Gene Tree: Tnfrsf1b

Human
homologs
TNFRSF1B, tumor necrosis factor receptor superfamily, member 1B
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7133
neXtProt AC: NX_P20333

Human Synonyms: CD120b, p75, p75TNFR, TBPII, TNFBR, TNFR1B, TNFR2, TNF-R75, TNFR80, TNF-R-II

Human Chr (Location): 1p36.22; chr1:12166949-12209222 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Genomic Mutations involving Tnfrsf1b (1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygotes for targeted null mutations exhibit altered inflammatory responses in a variety of experimental conditions, impaired recovery from spinal cord injury, enhanced ischemia-reperfusion-induced retinal damage, and resistance to cerebral malaria.
 
Mutations Annotated to Human Diseases (1)   
Interactions
Tnfrsf1b interacts with 296 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (28 annotations)
Process cell proliferation, cell surface receptor signaling pathway, ...
Component axon, integral component of membrane, ...
Function protein binding, tumor necrosis factor-activated receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (71)    Tissues (52)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 24
RT-PCR 47
cDNA source data(58)
Other mouse links: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(67) Genomic(3) cDNA(58) Primer pair(4) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000010013 (Evidence)
Ensembl Gene Model ENSMUSG00000028599 (Evidence)
Entrez Gene 21938 (Evidence)
UniGene 235328
DFCI TC1689345, TC1661139, TC1595728, TC1579636
DoTS DT.94242957, DT.530717
NIA Mouse Gene Index U025769
Consensus CDS Project CCDS18914.1
International Mouse Phenotyping Consortium Status Tnfrsf1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010013 VEGA Gene Model | MGI Sequence Detail 33408 C57BL/6J ±  kb
transcript OTTMUST00000023284 VEGA | MGI Sequence Detail 3818 Not Applicable 
polypeptide OTTMUSP00000010647 VEGA | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(5)
Polymorphisms
All PCR and RFLP(6) : PCR(2) RFLP(4) SNPs within 2kb(350 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR020411 Tumour necrosis factor receptor 1B
Protein Ontology PR:000001959 tumor necrosis factor receptor superfamily member 1B
References
(Earliest) J:11097 Lewis M, et al., Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2830-4
(Latest) J:220130 Eaton LH, et al., Skin sensitization induced Langerhans' cell mobilization: variable requirements for tumour necrosis factor-alpha. Immunology. 2015 Jan;144(1):139-48
All references(445)
Disease annotation references (1)
Other
accession IDs
MGD-MRK-15154, MGD-MRK-15157, MGI:98782

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/21/2015
MGI 5.22
The Jackson Laboratory