Tnfrsf1b
Gene Detail

Symbol Name ID

Tnfrsf1b tumor necrosis factor receptor superfamily, member 1b MGI:1314883

STS

D4Mit233

Synonyms

CD120b, p75, p75 TNFR, TNF-alphaR2, TNFalpha-R2, TNFBR, Tnfr2, TNF-R2, TNF-R75, TNFR80, TNFRII, TNF-R-II

Feature Type

protein coding gene

Genetic Map

Chromosome 4

78.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)

Sequence Map

Chr4:145213463-145246870 bp, - strand From VEGA annotation of GRCm38   33408 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:829  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tumor necrosis factor receptor type 2
Gene Tree: Tnfrsf1b

Human homologs

Human Homolog		TNFRSF1B, tumor necrosis factor receptor superfamily, member 1B
NCBI Gene ID		7133
neXtProt AC		NX_P20333
Human Synonyms		CD120b, p75, p75TNFR, TBPII, TNFBR, TNFR1B, TNFR2, TNF-R75, TNFR80, TNF-R-II
Human Chr (Location)		1p36.22; chr1:12227060-12269277 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(4) : Targeted(4)
 

Homozygotes for targeted null mutations exhibit altered inflammatory responses in a variety of experimental conditions, impaired recovery from spinal cord injury, enhanced ischemia-reperfusion-induced retinal damage, and resistance to cerebral malaria.

 
Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	cell death, cell proliferation, ...
Component	axon, integral to membrane, ...
Function	protein binding, tumor necrosis factor-activated receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (71)    Tissues (48)    Images (2)
Theiler Stages: 16, 18, 19, 20, 21, 23, 25, 28

Assay Type	Results
RNA in situ	24
RT-PCR	47

cDNA source data(57)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(66) Genomic(3) cDNA(57) Primer pair(4) Other(2)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000010013 (Evidence)
Ensembl Gene Model	ENSMUSG00000028599 (Evidence)
Entrez Gene	21938 (Evidence)
UniGene	235328
DFCI	TC1579636, TC1595728, TC1661139, TC1689345
DoTS	DT.530717, DT.94242957
NIA Mouse Gene Index	U025769
Consensus CDS Project	CCDS18914.1
International Mouse Knockout Project Status	Tnfrsf1b

Sequences

Length	Strain/Species
genomic	OTTMUSG00000010013	VEGA Gene Model | MGI Sequence Detail	33408	C57BL/6J
transcript	OTTMUST00000023284	VEGA | MGI Sequence Detail	3818	Not Applicable
polypeptide	OTTMUSP00000010647	VEGA | MGI Sequence Detail	474	Not Applicable

All sequences(40) RefSeq(2) UniProt(5)

Polymorphisms

All PCR and RFLP(6) : PCR(2) RFLP(4) SNPs(153 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR001368	TNFR/NGFR cysteine-rich region
InterPro	IPR020411	Tumour necrosis factor receptor 1B
Protein Ontology	PR:000001959	tumor necrosis factor receptor superfamily member 1B

References

(Earliest) J:399 Milatovich A, et al., Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. Somat Cell Mol Genet. 1991 Sep;17(5):519-23
(Latest) J:193029 Chen X, et al., TNFR2 is critical for the stabilization of the CD4+Foxp3+ regulatory T. cell phenotype in the inflammatory environment. J Immunol. 2013 Feb 1;190(3):1076-84
All references(403)

Other accession IDs

MGD-MRK-15154, MGD-MRK-15157, MGI:98782