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Tnfrsf1b Gene Detail
Summary
  • Symbol
    Tnfrsf1b
  • Name
    tumor necrosis factor receptor superfamily, member 1b
  • Synonyms
    CD120b, p75, p75 TNFR, TNF-alphaR2, TNFalpha-R2, TNFBR, Tnfr2, TNF-R2, TNF-R75, TNFR80, TNFRII, TNF-R-II
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314883
    NCBI Gene: 21938
Location & Maps
more
  • Sequence Map
    Chr4:145213463-145246870 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      33408 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    TNFRSF1B, tumor necrosis factor receptor superfamily member 1B
  • Vertebrate Orthologs
    8
  • Human Ortholog
    TNFRSF1B, tumor necrosis factor receptor superfamily member 1B
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD120b, p75, p75TNFR, TBPII, TNFBR, TNFR1B, TNFR2, TNF-R75, TNFR80, TNF-R-II
  • Links
    NCBI Gene ID: 7133
    neXtProt AC: NX_P20333

  • Chr Location
    1p36.22; chr1:12166949-12209222 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    2 with Tnfrsf1b mouse models

Human Disease Mouse Models
       Hyperlipidemia, Familial Combined; FCHL   OMIM: 144250
Hypertension, Essential   OMIM: 145500
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    28 phenotypes from 3 alleles in 8 genetic backgrounds
    59 phenotypes from multigenic genotypes
    332 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Chemically induced (other)
    1
  • Targeted
    5
  • Transgenic
    2
  • Genomic Mutations
    2 involving Tnfrsf1b
  • Incidental Mutations
Homozygotes for targeted null mutations exhibit altered inflammatory responses in a variety of experimental conditions, impaired recovery from spinal cord injury, enhanced ischemia-reperfusion-induced retinal damage, and resistance to cerebral malaria.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010013 VEGA Gene Model | MGI Sequence Detail 33408 C57BL/6J ±  kb
transcript OTTMUST00000023284 VEGA | MGI Sequence Detail 3818 Not Applicable  
polypeptide OTTMUSP00000010647 VEGA | MGI Sequence Detail 474 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    350 from dbSNP Build 137
  • PCR
  • RFLP
Protein
Information
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  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000001959 tumor necrosis factor receptor superfamily member 1B
  • InterPro Domains
    IPR001368 TNFR/NGFR cysteine-rich region
    IPR020411 Tumour necrosis factor receptor 1B
Molecular
Reagents
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  • All nucleic 67
    Genomic 3
    cDNA 58
    Primer pair 4
    Other 2

    Microarray probesets 4
Other
Accession IDs
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MGD-MRK-15154, MGD-MRK-15157, MGI:98782
References
more
  • Summaries
    All 451
    Developmental Gene Expression 8
    Diseases 2
    Gene Ontology 11
    Phenotypes 332
  • Earliest
    J:11097 Lewis M, et al., Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific. Proc Natl Acad Sci U S A. 1991 Apr 1;88(7):2830-4
  • Latest
    J:227277 Ham B, et al., TNF Receptor-2 Facilitates an Immunosuppressive Microenvironment in the Liver to Promote the Colonization and Growth of Hepatic Metastases. Cancer Res. 2015 Dec 15;75(24):5235-47

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory