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Tnfrsf1b
Gene Detail
 Symbol
Name
ID
Tnfrsf1b
tumor necrosis factor receptor superfamily, member 1b
MGI:1314883
STS D4Mit233
Synonyms CD120b, p75, p75 TNFR, TNF-alphaR2, TNFalpha-R2, TNFBR, Tnfr2, TNF-R2, TNF-R75, TNFR80, TNFRII, TNF-R-II
Feature Type protein coding gene
Genetic Map
Chromosome 4
78.17 cM
Detailed Genetic Map ± 1 cM


Mapping data(18)
Sequence Map
Chr4:145213463-145246870 bp, - strand
From VEGA annotation of GRCm38

  33408 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:829  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: tumor necrosis factor receptor type 2
Gene Tree: Tnfrsf1b

Human
homologs
Human Homolog TNFRSF1B, tumor necrosis factor receptor superfamily, member 1B
NCBI Gene ID 7133
neXtProt AC  NX_P20333
Human Synonyms  CD120b, p75, p75TNFR, TBPII, TNFBR, TNFR1B, TNFR2, TNF-R75, TNFR80, TNF-R-II
Human Chr (Location)  1p36.22; chr1:12167003-12209220 (+)  GRCh38
Alleles
and
phenotypes
All alleles(4) : Targeted(4)
 
Homozygotes for targeted null mutations exhibit altered inflammatory responses in a variety of experimental conditions, impaired recovery from spinal cord injury, enhanced ischemia-reperfusion-induced retinal damage, and resistance to cerebral malaria.
 
Alleles Annotated to Human Diseases(1)   
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cell death, cell proliferation, ...
Component axon, integral component of membrane, ...
Function protein binding, tumor necrosis factor-activated receptor activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (71)    Tissues (48)    Images (2)
Theiler Stages: 16, 18, 19, 20, 21, 23, 25, 28
Assay TypeResults
RNA in situ 24
RT-PCR 47
cDNA source data(58)
External Resources: Allen Institute   GEO   ArrayExpress
Molecular
reagents
All nucleic(67) Genomic(3) cDNA(58) Primer pair(4) Other(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000010013 (Evidence)
Ensembl Gene ModelENSMUSG00000028599 (Evidence)
Entrez Gene21938 (Evidence)
UniGene235328
DFCITC1579636, TC1595728, TC1661139, TC1689345
DoTSDT.530717, DT.94242957
NIA Mouse Gene IndexU025769
Consensus CDS ProjectCCDS18914.1
International Mouse Knockout Project StatusTnfrsf1b
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000010013 VEGA Gene Model | MGI Sequence Detail 33408 C57BL/6J ±  kb
transcript OTTMUST00000023284 VEGA | MGI Sequence Detail 3818 Not Applicable 
polypeptide OTTMUSP00000010647 VEGA | MGI Sequence Detail 474 Not Applicable 

For the selected sequences
All sequences(40) RefSeq(2) UniProt(5)
Polymorphisms All PCR and RFLP(6) : PCR(2) RFLP(4) SNPs within 2kb(350 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001368 TNFR/NGFR cysteine-rich region
InterPro IPR020411 Tumour necrosis factor receptor 1B
Protein Ontology PR:000001959 tumor necrosis factor receptor superfamily member 1B
References (Earliest) J:399 Milatovich A, et al., Tumor necrosis factor receptor genes, TNFR1 and TNFR2, on human chromosomes 12 and 1. Somat Cell Mol Genet. 1991 Sep;17(5):519-23
(Latest) J:207107 Ji R, et al., TAM receptors affect adult brain neurogenesis by negative regulation of microglial cell activation. J Immunol. 2013 Dec 15;191(12):6165-77
All references(424)
Other
accession IDs
MGD-MRK-15154, MGD-MRK-15157, MGI:98782

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
04/08/2014
MGI 5.17
The Jackson Laboratory