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Hipk1 Gene Detail
Summary
  • Symbol
    Hipk1
  • Name
    homeodomain interacting protein kinase 1
  • Synonyms
    1110062K04Rik, Myak
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314873
    NCBI Gene: 15257
  • Gene Overview
    MyGene.info: HIPK1
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:103739815-103791563 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 45.52 cM, cytoband F3
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    259 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1314873
 protein coding gene Chr3:103739815-103791894 (-)
129S1/SvImJ MGP_129S1SvImJ_G0027697
 protein coding gene Chr3:105028351-105079531 (-)
A/J MGP_AJ_G0027657
 protein coding gene Chr3:101683148-101734914 (-)
AKR/J MGP_AKRJ_G0027622
 protein coding gene Chr3:104165616-104216780 (-)
BALB/cJ MGP_BALBcJ_G0027669
 protein coding gene Chr3:101452229-101505026 (-)
C3H/HeJ MGP_C3HHeJ_G0027399
 protein coding gene Chr3:104534942-104586493 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028113
 protein coding gene Chr3:108922947-108974552 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025453
 protein coding gene Chr3:97809513-97861343 (-)
CAST/EiJ MGP_CASTEiJ_G0026855
 protein coding gene Chr3:103647010-103700912 (-)
CBA/J MGP_CBAJ_G0027374
 protein coding gene Chr3:112669649-112720905 (-)
DBA/2J MGP_DBA2J_G0027516
 protein coding gene Chr3:100928486-100980085 (-)
FVB/NJ MGP_FVBNJ_G0027484
 protein coding gene Chr3:98856657-98908095 (-)
LP/J MGP_LPJ_G0027623
 protein coding gene Chr3:106367877-106419777 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0027514
 protein coding gene Chr3:118775623-118827659 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028168
 protein coding gene Chr3:103721299-103774602 (-)
PWK/PhJ MGP_PWKPhJ_G0026581
 protein coding gene Chr3:100700136-100751637 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026402
 protein coding gene Chr3:101786071-101836769 (-)
WSB/EiJ MGP_WSBEiJ_G0026935
 protein coding gene Chr3:104269261-104322078 (-)



Homology
more
  • Human Ortholog
    HIPK1, homeodomain interacting protein kinase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HIPK1, homeodomain interacting protein kinase 1
    Orthology source: HomoloGene, HGNC
  • Synonyms
    Myak, Nbak2
  • Links
    NCBI Gene ID: 204851
    neXtProt AC: NX_Q86Z02
    UniProt: Q86Z02

  • Chr Location
    1p13.2; chr1:113929197-113977869 (+)  GRCh38.p7
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice are viable and fertile, do not develop spontaneous tumors, and are resistant to DMBA-induced skin tumor formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    48
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    654
  • Tissues
    16
  • cDNA Data
    157
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000008730 Ensembl Gene Model | MGI Sequence Detail 51749 C57BL/6J ±  kb
    transcript ENSMUST00000118317 Ensembl | MGI Sequence Detail 7939 Not Applicable  
    polypeptide ENSMUSP00000113998 Ensembl | MGI Sequence Detail 1210 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 160
      cDNA 158
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGI:1916099
    References
    more
    • Summaries
      All 47
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 11
      Phenotypes 14
    • Earliest
      J:50387 Kim YH, et al., Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998 Oct 2;273(40):25875-9
    • Latest
      J:295163 Liu B, et al., miR-200c/141 Regulates Breast Cancer Stem Cell Heterogeneity via Targeting HIPK1/beta-Catenin Axis. Theranostics. 2018;8(21):5801-5813
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/20/2020
    MGI 6.16     		The Jackson Laboratory