Hipk1 Gene Detail

Summary

• Symbol
  Hipk1
• Name
  homeodomain interacting protein kinase 1
• Synonyms
  1110062K04Rik, Myak

• Feature Type
  protein coding gene
• IDs
  MGI:1314873
  NCBI Gene: 15257
• Gene Overview
  MyGene.info: HIPK1
• Alliance
  gene page

Location & Maps

• Sequence Map
  Chr3:103739815-103791563 bp, - strand
• From VEGA annotation of GRCm38
  

  Mouse Genome Browser
  
  

• Download
  Sequence
    51749 bp   ±  kb flank
  
  
• Genome Browsers
  VEGA | Ensembl | UCSC | NCBI

• Genetic Map
  Chromosome 3, 45.52 cM, cytoband F3
• Mapping Data
  3 experiments

Homology

• Human Ortholog
  HIPK1, homeodomain interacting protein kinase 1

• Vertebrate Orthologs
  9

• Human Ortholog
  HIPK1, homeodomain interacting protein kinase 1
  Orthology source: HomoloGene, HGNC
• Synonyms
  Myak, Nbak2
• Links
  HGNC:19006

  NCBI Gene ID: 204851

  neXtProt AC: NX_Q86Z02

  UniProt: Q86Z02

  
  
• Chr Location
  1p13.2; chr1:113929197-113977869 (+)  GRCh38.p7

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• HomoloGene
  Vertebrate Homology Class 56483
  1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
  
• HCOP
  human homology predictions: HIPK1
• Gene Tree
  Hipk1
  

Human Diseases

• References
  1 with disease annotations

Mutations,
Alleles, and
Phenotypes

• Phenotype Summary
  3 phenotypes from 2 alleles in 2 genetic backgrounds
  9 phenotypes from multigenic genotypes
  14 phenotype references
  

• All Mutations and Alleles
  27
• Chemically induced (other)
  1
• Gene trapped
  22
• Radiation induced
  1
• Targeted
  3
• Genomic Mutations
  2 involving Hipk1
• Incidental Mutations
  Mutagenetix , APF , CvDC
• Find Mice (IMSR)
  22 strains or lines available
• Comparison Matrix
  Gene Expression + Phenotype

Homozygous null mice are viable and fertile, do not develop spontaneous tumors, and are resistant to DMBA-induced skin tumor formation.

Gene Ontology
(GO)
Classifications

• All GO Annotations
  41
• GO References
  10

• External Resources
  FuncBase

Expression

• Assay Results
  3
• Tissues
  1
• cDNA Data
  156
• Literature Summary
  5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

• Other Mouse Links
  Allen Institute
  GEO
  Expression Atlas
• Other Vertebrate Links
  Xenbase hipk1

Interactions

• Hipk1 interacts with 450 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

Sequences &
Gene Models

• All Sequences
  86
• RefSeq
  11
• UniProt
  16
• CCDS
  CCDS38576.1, CCDS79992.1
• UniGene
  20827

• VEGA
  OTTMUSG00000024242 (Evidence)
• Ensembl
  ENSMUSG00000008730 (Evidence)
• NCBI Gene
  15257 (Evidence)

Representative Sequences			Length	Strain/Species
genomic	OTTMUSG00000024242	VEGA Gene Model | MGI Sequence Detail	51749	C57BL/6J
transcript	OTTMUST00000067578	VEGA | MGI Sequence Detail	4185	Not Applicable
polypeptide	OTTMUSP00000034026	VEGA | MGI Sequence Detail	1210	Not Applicable

Polymorphisms

• SNPs within 2kb
  259 from dbSNP Build 142

Protein
Information

• UniProt
  16 Sequences
• Protein Ontology
  PR:000008566 homeodomain-interacting protein kinase 1
  (term hierarchy)
• EC
  2.7.11.1
• InterPro Domains
  IPR017441 Protein kinase, ATP binding site
  IPR000719 Protein kinase domain
  IPR011009 Protein kinase-like domain superfamily
  IPR008271 Serine/threonine-protein kinase, active site

Molecular
Reagents

• All nucleic 158

  cDNA 157

  Primer pair 1

  
  

  Microarray probesets 6

Other
Accession IDs

MGI:1916099

References

• Summaries
  All 46

  Developmental Gene Expression 5

  Diseases 1

  Gene Ontology 10

  Phenotypes 14
• Earliest
  J:50387 Kim YH, et al., Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998 Oct 2;273(40):25875-9
• Latest
  J:197686 Shang Y, et al., Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-beta-TAK1-dependent mechanism. PLoS Biol. 2013;11(4):e1001527