Hipk1 MGI Mouse Gene Detail - MGI:1314873 - homeodomain interacting protein kinase 1

Symbol

Hipk1
Name

homeodomain interacting protein kinase 1
Synonyms

1110062K04Rik, Myak

Feature Type

protein coding gene
IDs

MGI:1314873
NCBI Gene: 15257
Gene Overview

MyGene.info: HIPK1
Alliance

gene page
Transcription Start Sites

11 TSS

Sequence Map

Chr3:103739815-103791563 bp, - strand
From Ensembl annotation of GRCm38

View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 3, 45.52 cM, cytoband F3
Mapping Data

3 experiments

SNPs within 2kb

259 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1314873	protein coding gene	Chr3:103739815-103791894 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0027697	protein coding gene	Chr3:105028351-105079531 (-)
A/J	MGP_AJ_G0027657	protein coding gene	Chr3:101683148-101734914 (-)
AKR/J	MGP_AKRJ_G0027622	protein coding gene	Chr3:104165616-104216780 (-)
BALB/cJ	MGP_BALBcJ_G0027669	protein coding gene	Chr3:101452229-101505026 (-)
C3H/HeJ	MGP_C3HHeJ_G0027399	protein coding gene	Chr3:104534942-104586493 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0028113	protein coding gene	Chr3:108922947-108974552 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0025453	protein coding gene	Chr3:97809513-97861343 (-)
CAST/EiJ	MGP_CASTEiJ_G0026855	protein coding gene	Chr3:103647010-103700912 (-)
CBA/J	MGP_CBAJ_G0027374	protein coding gene	Chr3:112669649-112720905 (-)
DBA/2J	MGP_DBA2J_G0027516	protein coding gene	Chr3:100928486-100980085 (-)
FVB/NJ	MGP_FVBNJ_G0027484	protein coding gene	Chr3:98856657-98908095 (-)
LP/J	MGP_LPJ_G0027623	protein coding gene	Chr3:106367877-106419777 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0027514	protein coding gene	Chr3:118775623-118827659 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0028168	protein coding gene	Chr3:103721299-103774602 (-)
PWK/PhJ	MGP_PWKPhJ_G0026581	protein coding gene	Chr3:100700136-100751637 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0026402	protein coding gene	Chr3:101786071-101836769 (-)
WSB/EiJ	MGP_WSBEiJ_G0026935	protein coding gene	Chr3:104269261-104322078 (-)

Human Ortholog

HIPK1, homeodomain interacting protein kinase 1

Vertebrate Orthologs

9

Human Ortholog

HIPK1, homeodomain interacting protein kinase 1
Orthology source: HomoloGene, HGNC
Synonyms

Myak, Nbak2
Links

HGNC:19006

NCBI Gene ID: 204851

neXtProt AC: NX_Q86Z02

UniProt: Q86Z02
Chr Location

1p13.2; chr1:113929197-113977869 (+) GRCh38.p7

HomoloGene

Vertebrate Homology Class 56483
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 frog, western clawed;1 macaque, rhesus
HCOP

human homology predictions: HIPK1
Gene Tree

Hipk1

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References

1 with disease annotations

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Phenotype Summary

3 phenotypes from 2 alleles in 2 genetic backgrounds
9 phenotypes from multigenic genotypes
14 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	immune system	integument	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	neoplasm	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	vision/eye

Click cells to view annotations.

All Mutations and Alleles

27
Chemically induced (other)

1
Gene trapped

22
Radiation induced

1
Targeted

3
Genomic Mutations

2 involving Hipk1
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

22 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous null mice are viable and fertile, do not develop spontaneous tumors, and are resistant to DMBA-induced skin tumor formation.

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All GO Annotations

48
GO References

11

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell death	cell differentiation	cell population proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	nucleic acid-templated transcription	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Assay Results

3
Tissues

1
cDNA Data

156
Literature Summary

5

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

Xenbase hipk1

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Hipk1 interacts with 450 markers (Mir1a-1, Mir1a-2, Mir1b, ...) View All

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All Sequences

91
RefSeq

10
UniProt

16
CCDS

CCDS38576.1, CCDS79992.1
UniGene

20827

Ensembl

ENSMUSG00000008730 (Evidence)
NCBI Gene

15257 (Evidence)

			Length	Strain/Species	Flank
genomic	ENSMUSG00000008730	Ensembl Gene Model \| MGI Sequence Detail	51749	C57BL/6J	± kb
transcript	ENSMUST00000118317	Ensembl \| MGI Sequence Detail	7939	Not Applicable
polypeptide	ENSMUSP00000113998	Ensembl \| MGI Sequence Detail	1210	Not Applicable

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UniProt

16 Sequences
Protein Ontology

PR:000008566 homeodomain-interacting protein kinase 1

(term hierarchy)
EC

2.7.11.1
InterPro Domains

IPR017441 Protein kinase, ATP binding site

IPR000719 Protein kinase domain

IPR011009 Protein kinase-like domain superfamily

IPR008271 Serine/threonine-protein kinase, active site

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All nucleic 158

cDNA 157

Primer pair 1

Microarray probesets 6

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MGI:1916099

Summaries

All 46

Developmental Gene Expression 5

Diseases 1

Gene Ontology 11

Phenotypes 14
Earliest

J:50387 Kim YH, et al., Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998 Oct 2;273(40):25875-9
Latest

J:197686 Shang Y, et al., Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-beta-TAK1-dependent mechanism. PLoS Biol. 2013;11(4):e1001527

TSS for Hipk1:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr34860	Chr3:103791921-103791936 (-)	-366 bp
Tssr34859	Chr3:103791573-103791606 (-)	-27 bp
Tssr34858	Chr3:103791537-103791563 (-)	13 bp
Tssr34857	Chr3:103791387-103791410 (-)	164 bp
Tssr34856	Chr3:103791222-103791318 (-)	293 bp
Tssr34855	Chr3:103778309-103778326 (-)	13,245 bp
Tssr34854	Chr3:103778257-103778277 (-)	13,296 bp
Tssr34853	Chr3:103778188-103778201 (-)	13,368 bp
Tssr34852	Chr3:103778156-103778177 (-)	13,396 bp
Tssr34851	Chr3:103778135-103778151 (-)	13,420 bp
Tssr34848	Chr3:103741940-103741944 (-)	49,621 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer & Copyright Notice Send questions and comments to User Support.	last database update 10/08/2019 MGI 6.14