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Hipk1 Gene Detail
Summary
  • Symbol
    Hipk1
  • Name
    homeodomain interacting protein kinase 1
  • Synonyms
    1110062K04Rik, Myak
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314873
    NCBI Gene: 15257
  • Gene Overview
    MyGene.info: HIPK1
Location & Maps
more
  • Sequence Map
    Chr3:103739815-103791563 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      51749 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 45.52 cM, cytoband F3
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    3 experiments
Homology
more
  • Human Ortholog
    HIPK1, homeodomain interacting protein kinase 1
  • Vertebrate Orthologs
    9
  • Human Ortholog
    HIPK1, homeodomain interacting protein kinase 1
    Orthology source: HGNC, HomoloGene
  • Synonyms
    Myak, Nbak2
  • Links
    NCBI Gene ID: 204851
    neXtProt AC: NX_Q86Z02

  • Chr Location
    1p13.2; chr1:113929197-113977869 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    9 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    27
  • Chemically induced (other)
    1
  • Gene trapped
    22
  • Radiation induced
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Hipk1
  • Incidental Mutations
Homozygous null mice are viable and fertile, do not develop spontaneous tumors, and are resistant to DMBA-induced skin tumor formation.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024242 VEGA Gene Model | MGI Sequence Detail 51749 C57BL/6J ±  kb
transcript OTTMUST00000067578 VEGA | MGI Sequence Detail 4185 Not Applicable  
polypeptide OTTMUSP00000034026 VEGA | MGI Sequence Detail 1210 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    259 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 157
    cDNA 156
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1916099
References
more
  • Summaries
    All 40
    Developmental Gene Expression 5
    Gene Ontology 10
    Phenotypes 14
  • Earliest
    J:50387 Kim YH, et al., Homeodomain-interacting protein kinases, a novel family of co-repressors for homeodomain transcription factors. J Biol Chem. 1998 Oct 2;273(40):25875-9
  • Latest
    J:197686 Shang Y, et al., Transcriptional corepressors HIPK1 and HIPK2 control angiogenesis via TGF-beta-TAK1-dependent mechanism. PLoS Biol. 2013;11(4):e1001527

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory