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Mllt4
Gene Detail
 Symbol
Name
ID
Mllt4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MGI:1314653
Synonyms 5033403D15Rik, AF6, Afadin, I-afadin, S-afadin
Feature Type protein coding gene
Genetic Map
Chromosome 17
8.95 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr17:13760539-13906150 bp, + strand
From VEGA annotation of GRCm38

  145612 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21202  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Mllt4

Human
homologs
Human Homolog MLLT4, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
NCBI Gene ID 4301
neXtProt AC  NX_P55196
Human Synonyms  AF6
Human Chr (Location)  6q27; chr6:167826922-167972023 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(32) : Gene trapped(26) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display embryonic lethality, abnormal ectoderm development including disrupted cell junctions, and absence of the somites, notochord, allantois, and neural folds.
 
Interactions
Mllt4 interacts with 361 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process cell adhesion, signal transduction
Component adherens junction, apical part of cell, ...
Function cell adhesion molecule binding, LIM domain binding, ...
External Resources: FuncBase
Expression
Literature Summary: (22 records)
Data Summary: Results (47)    Tissues (40)    Images (20)
Theiler Stages: 15, 17, 19, 20, 21, 22, 23, 26, 28
Assay TypeResults
Immunohistochemistry 15
RNA in situ 32
cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(26) Genomic(2) cDNA(23) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000029503 (Evidence)
Ensembl Gene ModelENSMUSG00000068036 (Evidence)
Entrez Gene17356 (Evidence)
NIA Mouse Gene IndexU017512
PDB1WLN, 1WXA, 3AXA
Consensus CDS ProjectCCDS49955.1
International Mouse Knockout Project StatusMllt4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000029503 VEGA Gene Model | MGI Sequence Detail 145612 C57BL/6J ±  kb
transcript OTTMUST00000073198 VEGA | MGI Sequence Detail 5684 Not Applicable 
polypeptide OTTMUSP00000037865 VEGA | MGI Sequence Detail 1827 Not Applicable 

For the selected sequences
All sequences(121) RefSeq(37) UniProt(8)
Polymorphisms SNPs within 2kb(289 from dbSNP Build 137)    SNPs within 2kb including multiple locations(341)
Protein-related
information
ResourceIDDescription
InterPro IPR018444 Dil domain
InterPro IPR002710 Dilute
InterPro IPR000253 Forkhead-associated (FHA) domain
InterPro IPR001478 PDZ domain
InterPro IPR000159 Ras-association
InterPro IPR008984 SMAD/FHA domain
Protein Ontology PR:000010453 afadin
References (Earliest) J:49560 Hock B, et al., PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9779-84
(Latest) J:206576 Fukuda T, et al., Aberrant cochlear hair cell attachments caused by Nectin-3 deficiency result in hair bundle abnormalities. Development. 2014 Jan;141(2):399-409
All references(77)
Other
accession IDs
MGI:2685160

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory