Mllt4
Gene Detail

Symbol

Name
ID

Mllt4
myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
MGI:1314653

Synonyms

5033403D15Rik, AF6, Afadin, I-afadin, S-afadin

Feature Type

protein coding gene

Genetic Map

Chromosome 17
8.95 cM, cytoband A2
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr17:13760539-13906150 bp, + strand From VEGA annotation of GRCm38   145612 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:21202  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Mllt4

Human
homologs

Human Homolog		MLLT4, myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 4
NCBI Gene ID		4301
neXtProt AC		NX_P55196
Human Synonyms		AF6
Human Chr (Location)		6q27; chr6:167826922-167972023 (+)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(33) : Gene trapped(26) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 

Homozygous null mice display embryonic lethality, abnormal ectoderm development including disrupted cell junctions, and absence of the somites, notochord, allantois, and neural folds.

 

Interactions

Mllt4 interacts with 361 markers (Mir1a-1, Mir1a-2, Mir9-1, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (18 annotations)

Process	cell adhesion, establishment of endothelial intestinal barrier, ...
Component	adherens junction, apical part of cell, ...
Function	cell adhesion molecule binding, LIM domain binding, ...

External Resources: FuncBase

Expression

Literature Summary: (25 records)

Data Summary: Results (47)    Tissues (40)    Images (20)    Tissue x Stage Matrix (view)

Assay Type	Results
Immunohistochemistry	15
RNA in situ	32

cDNA source data(20)
External Resources: Allen Institute   GEO   Expression Atlas

Molecular
reagents

All nucleic(26) Genomic(2) cDNA(23) Other(1)
Microarray probesets(6)

Other database
links

VEGA Gene Model	OTTMUSG00000029503 (Evidence)
Ensembl Gene Model	ENSMUSG00000068036 (Evidence)
Entrez Gene	17356 (Evidence)
NIA Mouse Gene Index	U017512
PDB	1WLN, 3AXA, 1WXA
Consensus CDS Project	CCDS49955.1
International Mouse Knockout Project Status	Mllt4

Sequences

Length	Strain/Species
genomic	OTTMUSG00000029503	VEGA Gene Model | MGI Sequence Detail	145612	C57BL/6J
transcript	OTTMUST00000073198	VEGA | MGI Sequence Detail	5684	Not Applicable
polypeptide	OTTMUSP00000037865	VEGA | MGI Sequence Detail	1827	Not Applicable

All sequences(119) RefSeq(35) UniProt(8)

Polymorphisms

SNPs within 2kb(289 from dbSNP Build 137)    SNPs within 2kb including multiple locations(341)

Protein-related
information

Resource	ID	Description
InterPro	IPR018444	Dil domain
InterPro	IPR002710	Dilute
InterPro	IPR000253	Forkhead-associated (FHA) domain
InterPro	IPR001478	PDZ domain
InterPro	IPR000159	Ras-association
InterPro	IPR008984	SMAD/FHA domain
Protein Ontology	PR:000010453	afadin

References

(Earliest) J:49560 Hock B, et al., PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. Proc Natl Acad Sci U S A. 1998 Aug 18;95(17):9779-84
(Latest) J:215584 Gil-Sanz C, et al., Proliferative defects and formation of a double cortex in mice lacking Mltt4 and Cdh2 in the dorsal telencephalon. J Neurosci. 2014 Aug 6;34(32):10475-87
All references(81)

Other
accession IDs

MGI:2685160