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Aqp7 Gene Detail
Summary
  • Symbol
    Aqp7
  • Name
    aquaporin 7
  • Synonyms
    AQP7L, AQPap
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314647
    NCBI Gene: 11832
  • Gene Overview
    MyGene.info: AQP7
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr4:41033074-41048139 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      15066 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 20.83 cM, cytoband B1
  • Mapping Data
    1 experiment
Homology
more
  • Human Ortholog
    AQP7, aquaporin 7
  • Vertebrate Orthologs
    9
  • Human Ortholog
    AQP7, aquaporin 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    AQP7L, AQPap, GLYCQTL
  • Links
    NCBI Gene ID: 364
    neXtProt AC: NX_O14520
    UniProt: O14520

  • Chr Location
    9p13.3; chr9:33383135-33402682 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    21 phenotypes from 5 alleles in 6 genetic backgrounds
    5 phenotypes from multigenic genotypes
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous null mice for one allele show decreased circulating glycerol levels and fasting hypoglycemia. Other mutant alleles show increased gonadal fat pad mass and adipocyte hypertrophy or increased urine glucose and impaired water permeability in the kidney, but have normal serum glycerol.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000006623 VEGA Gene Model | MGI Sequence Detail 15066 C57BL/6J ±  kb
    transcript OTTMUST00000015107 VEGA | MGI Sequence Detail 2527 Not Applicable  
    polypeptide OTTMUSP00000006986 VEGA | MGI Sequence Detail 303 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      39 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      cDNA 17
      Primer pair 2

      Microarray probesets 4
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 15
    • Earliest
      J:49128 Ishibashi K, et al., Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping. Biochim Biophys Acta. 1998 Jul 30;1399(1):62-6
    • Latest
      J:250201 Tanahashi H, et al., Polyhydramnios in Lrp4 knockout mice with bilateral kidney agenesis: Defects in the pathways of amniotic fluid clearance. Sci Rep. 2016 Feb 5;6:20241

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory