About   Help   FAQ
Aqp7
Gene Detail
Symbol

Name
ID
Aqp7
aquaporin 7
MGI:1314647
Synonyms
AQP7L, AQPap
Feature Type
protein coding gene
Genetic Map
Chromosome 4
20.83 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:41033074-41048139 bp, - strand
From VEGA annotation of GRCm38

  15066 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48000  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: AQP7
Protein SuperFamily: aquaporin
Gene Tree: Aqp7

Human
homologs
AQP7, aquaporin 7
Orthology source: HomoloGene

IDs:
NCBI Gene ID: 364
neXtProt AC: NX_O14520

Human Synonyms: AQP7L, AQP9, AQPap, GLYCQTL

Human Chr (Location): 9p13; chr9:33384947-33402645 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Homozygous null mice for one allele show decreased circulating glycerol levels and fasting hypoglycemia. Other mutant alleles show increased gonadal fat pad mass and adipocyte hypertrophy or increased urine glucose and impaired water permeability in the kidney, but have normal serum glycerol.
 
Interactions
Aqp7 interacts with 140 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (35 annotations)
Process carbohydrate transmembrane transport, cellular water homeostasis, ...
Component brush border membrane, cell, ...
Function glycerol channel activity, transporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (18)    Tissues (13)    Images (2)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 4
Western blot 1
RT-PCR 13
cDNA source data(16)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase aqp7 ; ZFIN aqp7    NEW 
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000006623 (Evidence)
Ensembl Gene Model ENSMUSG00000028427 (Evidence)
Entrez Gene 11832 (Evidence)
UniGene 8728
DFCI TC1584618, TC1661696
DoTS DT.484959, DT.91334225, DT.97342299
NIA Mouse Gene Index U024965
Consensus CDS Project CCDS18055.1
International Mouse Phenotyping Consortium Status Aqp7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006623 VEGA Gene Model | MGI Sequence Detail 15066 C57BL/6J ±  kb
transcript OTTMUST00000015107 VEGA | MGI Sequence Detail 2527 Not Applicable 
polypeptide OTTMUSP00000006986 VEGA | MGI Sequence Detail 303 Not Applicable 

For the selected sequences
All sequences(43) RefSeq(12) UniProt(2)
Polymorphisms
SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015686 Aquaporin 7
InterPro IPR023271 Aquaporin-like
InterPro IPR000425 Major intrinsic protein
Protein Ontology PR:000004187 aquaporin-7
References
(Earliest) J:49128 Ishibashi K, et al., Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping. Biochim Biophys Acta. 1998 Jul 30;1399(1):62-6
(Latest) J:220015 Miyauchi T, et al., Dynamic subcellular localization of aquaporin-7 in white adipocytes. FEBS Lett. 2015 Feb 27;589(5):608-14
All references(52)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/18/2015
MGI 6.0
The Jackson Laboratory