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Aqp7
Gene Detail
 Symbol
Name
ID
Aqp7
aquaporin 7
MGI:1314647
Synonyms AQP7L, AQPap
Feature Type protein coding gene
Genetic Map
Chromosome 4
20.83 cM, cytoband B1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:41033074-41048139 bp, - strand
From VEGA annotation of GRCm38

  15066 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:48000  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: aquaporin
Gene Tree: Aqp7

Human
homologs
Human Homolog AQP7, aquaporin 7
NCBI Gene ID 364
neXtProt AC  NX_O14520
Human Synonyms  AQP7L, AQP9, AQPap, GLYCQTL
Human Chr (Location)  9p13; chr9:33384950-33402645 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice for one allele show decreased circulating glycerol levels and fasting hypoglycemia. Other mutant alleles show increased gonadal fat pad mass and adipocyte hypertrophy or increased urine glucose and impaired water permeability in the kidney, but have normal serum glycerol.
 
Interactions
Aqp7 interacts with 140 markers (Mir10a, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (31 annotations)
Process carbohydrate transmembrane transport, glycerol transport, ...
Component brush border membrane, cell-cell junction, ...
Function glycerol channel activity, porin activity, ...
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (29)    Tissues (18)    Images (2)
Theiler Stages: 2, 3, 4, 5, 28
Assay TypeResults
Immunohistochemistry 4
Western blot 1
RT-PCR 24
cDNA source data(16)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) cDNA(16) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000006623 (Evidence)
Ensembl Gene ModelENSMUSG00000028427 (Evidence)
Entrez Gene11832 (Evidence)
UniGene8728
DFCITC1584618, TC1661696
DoTSDT.484959, DT.91334225, DT.97342299
NIA Mouse Gene IndexU024965
Consensus CDS ProjectCCDS18055.1
International Mouse Knockout Project StatusAqp7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000006623 VEGA Gene Model | MGI Sequence Detail 15066 C57BL/6J ±  kb
transcript OTTMUST00000015107 VEGA | MGI Sequence Detail 2527 Not Applicable 
polypeptide OTTMUSP00000006986 VEGA | MGI Sequence Detail 303 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(14) UniProt(2)
Polymorphisms SNPs within 2kb(39 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR015686 Aquaporin 7
InterPro IPR023271 Aquaporin-like
InterPro IPR000425 Major intrinsic protein
Protein Ontology PR:000004187 aquaporin-7
References (Earliest) J:49128 Ishibashi K, et al., Molecular characterization of human Aquaporin-7 gene and its chromosomal mapping. Biochim Biophys Acta. 1998 Jul 30;1399(1):62-6
(Latest) J:187152 Shen FX, et al., Over-expression of AQP7 contributes to improve insulin resistance in adipocytes. Exp Cell Res. 2012 Nov 1;318(18):2377-84
All references(52)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory