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Dnase1l3
Gene Detail
Symbol

Name
ID
Dnase1l3
deoxyribonuclease 1-like 3
MGI:1314633
Synonyms
DNasegamma
Feature Type
protein coding gene
Genetic Map
Chromosome 14
4.67 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:7964533-7994573 bp, - strand
From VEGA annotation of GRCm38

  30041 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3630  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

HCOP human homology predictions: DNASE1L3
Protein SuperFamily: deoxyribonuclease I
Gene Tree: Dnase1l3

Human
homologs
DNASE1L3, deoxyribonuclease I-like 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1776
neXtProt AC: NX_Q13609

Human Synonyms: DHP2, DNAS1L3, LSD, SLEB16

Human Chr (Location): 3p14.3; chr3:58192626-58211003 (-)  GRCh38.p2

Disease Associations: (1) Diseases Associated with Human DNASE1L3

Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired necrosis-associated internucleosomal DNA fragmentation.
 
Interactions
Dnase1l3 interacts with 263 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process apoptotic DNA fragmentation, apoptotic process, ...
Component nucleus
Function deoxyribonuclease activity, DNA binding, ...
External Resources: FuncBase
Expression
cDNA source data(10)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase dnase1l3    NEW 
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(6)
Other database
links
VEGA Gene Model OTTMUSG00000024054 (Evidence)
Ensembl Gene Model ENSMUSG00000025279 (Evidence)
Entrez Gene 13421 (Evidence)
DFCI TC1583263, TC1658838, TC1660264
DoTS DT.40168583, DT.40173105, DT.40180903
NIA Mouse Gene Index U035226
EC 3.1.21.-
Consensus CDS Project CCDS26807.1
International Mouse Phenotyping Consortium Status Dnase1l3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024054 VEGA Gene Model | MGI Sequence Detail 30041 C57BL/6J ±  kb
transcript OTTMUST00000058813 VEGA | MGI Sequence Detail 4747 Not Applicable 
polypeptide OTTMUSP00000028548 VEGA | MGI Sequence Detail 310 Not Applicable 

For the selected sequences
All sequences(33) RefSeq(4) UniProt(3)
Polymorphisms
SNPs within 2kb(299 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR016202 Deoxyribonuclease I
InterPro IPR018057 Deoxyribonuclease I, active site
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
Protein Ontology PR:000006595 deoxyribonuclease gamma
References
(Earliest) J:49550 Baron WF, et al., Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages. Gene. 1998 Jul 30;215(2):291-301
(Latest) J:211019 Mizuta R, et al., DNase gamma is the effector endonuclease for internucleosomal DNA fragmentation in necrosis. PLoS One. 2013;8(12):e80223
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory