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Dnase1l3 Gene Detail
Summary
  • Symbol
    Dnase1l3
  • Name
    deoxyribonuclease 1-like 3
  • Synonyms
    DNasegamma
  • Feature Type
    protein coding gene
  • IDs
    MGI:1314633
    NCBI Gene: 13421
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:14475014-14504586 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 4.67 cM, cytoband A1
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    296 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1314633
 protein coding gene Chr14:14475014-14505240 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020985
 protein coding gene Chr14:293230-323244 (-)
A/J MGP_AJ_G0020933
 protein coding gene Chr14:276622-308771 (-)
AKR/J MGP_AKRJ_G0020910
 protein coding gene Chr14:269730-300634 (-)
BALB/cJ MGP_BALBcJ_G0020935
 protein coding gene Chr14:264089-298548 (-)
C3H/HeJ MGP_C3HHeJ_G0020720
 protein coding gene Chr14:280031-309894 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021369
 protein coding gene Chr14:298377-328318 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018938
 protein coding gene Chr14:1204286-1233694 (-)
CAST/EiJ MGP_CASTEiJ_G0020242
 protein coding gene Chr14:276151-306198 (-)
CBA/J MGP_CBAJ_G0020686
 protein coding gene Chr14:297322-327187 (-)
DBA/2J MGP_DBA2J_G0020809
 protein coding gene Chr14:256858-286741 (-)
FVB/NJ MGP_FVBNJ_G0020791
 protein coding gene Chr14:259954-289815 (-)
LP/J MGP_LPJ_G0020886
 protein coding gene Chr14:271950-301957 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020817
 protein coding gene Chr14:299529-329460 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021402
 protein coding gene Chr14:282089-311973 (-)
PWK/PhJ MGP_PWKPhJ_G0019994
 protein coding gene Chr14:280433-310608 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019815
 protein coding gene Chr14:274777-307845 (-)
WSB/EiJ MGP_WSBEiJ_G0020300
 protein coding gene Chr14:275192-306313 (-)



Homology
more
  • Human Ortholog
    DNASE1L3, deoxyribonuclease 1L3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DNASE1L3, deoxyribonuclease 1L3
  • Synonyms
    D3, DHP2, DNAS1L3, LSD, SLEB16
  • Links
    NCBI Gene ID: 1776
    neXtProt AC: NX_Q13609
    UniProt: Q13609

  • Chr Location
    3p14.3; chr3:58192257-58214697 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 2 alleles in 2 genetic backgrounds
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit impaired necrosis-associated internucleosomal DNA fragmentation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    706
  • cDNA Data
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13421 NCBI Gene Model | MGI Sequence Detail 29573 C57BL/6J ±  kb
    transcript NM_007870 RefSeq | MGI Sequence Detail 3702 C57BL/6  
    polypeptide O55070 UniProt | EBI | MGI Sequence Detail 310 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 6
    References
    more
    • Summaries
      All 46
      Gene Ontology 6
      Phenotypes 22
    • Earliest
      J:49550 Baron WF, et al., Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages. Gene. 1998 Jul 30;215(2):291-301
    • Latest
      J:346926 Englert H, et al., Targeting NETs using dual-active DNase1 variants. Front Immunol. 2023;14:1181761
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/16/2024
    MGI 6.23     		The Jackson Laboratory