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Dnase1l3
Gene Detail
Symbol

Name
ID
Dnase1l3
deoxyribonuclease 1-like 3
MGI:1314633
Synonyms
DNasegamma
Feature Type
protein coding gene
Genetic Map
Chromosome 14
4.67 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr14:7964533-7994573 bp, - strand
From VEGA annotation of GRCm38

  30041 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3630  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: deoxyribonuclease I
Gene Tree: Dnase1l3

Human
homologs
Human Homolog DNASE1L3, deoxyribonuclease I-like 3
NCBI Gene ID 1776
neXtProt AC  NX_Q13609
Human Synonyms  DHP2, DNAS1L3, LSD, SLEB16
Human Chr (Location)  3p14.3; chr3:58192626-58211003 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human DNASE1L3
Mutations,
alleles, and
phenotypes
All mutations/alleles(3) : Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a knock-out allele exhibit impaired necrosis-associated internucleosomal DNA fragmentation.
 
Interactions
Dnase1l3 interacts with 263 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process apoptotic DNA fragmentation, apoptotic process, ...
Component nucleus
Function deoxyribonuclease activity, DNA binding, ...
External Resources: FuncBase
Expression
cDNA source data(10)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(10) cDNA(10)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000024054 (Evidence)
Ensembl Gene ModelENSMUSG00000025279 (Evidence)
Entrez Gene13421 (Evidence)
DFCITC1658838, TC1583263, TC1660264
DoTSDT.40168583, DT.40173105, DT.40180903
NIA Mouse Gene IndexU035226
EC3.1.21.-
Consensus CDS ProjectCCDS26807.1
International Mouse Knockout Project StatusDnase1l3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000024054 VEGA Gene Model | MGI Sequence Detail 30041 C57BL/6J ±  kb
transcript OTTMUST00000058813 VEGA | MGI Sequence Detail 4747 Not Applicable 
polypeptide OTTMUSP00000028548 VEGA | MGI Sequence Detail 310 Not Applicable 

For the selected sequences
All sequences(35) RefSeq(4) UniProt(5)
Polymorphisms
SNPs within 2kb(299 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR018057 Deoxyribonuclease I, active site
InterPro IPR016202 Deoxyribonuclease I-like
InterPro IPR005135 Endonuclease/exonuclease/phosphatase
Protein Ontology PR:000006595 deoxyribonuclease gamma
References
(Earliest) J:49550 Baron WF, et al., Cloning and characterization of an actin-resistant DNase I-like endonuclease secreted by macrophages. Gene. 1998 Jul 30;215(2):291-301
(Latest) J:211019 Mizuta R, et al., DNase gamma is the effector endonuclease for internucleosomal DNA fragmentation in necrosis. PLoS One. 2013;8(12):e80223
All references(29)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/09/2014
MGI 5.20
The Jackson Laboratory