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Gpr37
Gene Detail
 Symbol
Name
ID
Gpr37
G protein-coupled receptor 37
MGI:1313297
Synonyms Pael-R, parkin-associated endothelin B-like receptor
Feature Type protein coding gene
Genetic Map
Chromosome 6
11.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:25668523-25689980 bp, - strand
From NCBI annotation of GRCm38

  21458 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3875  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: endothelin B receptor-like protein
Gene Tree: Gpr37

Human
homologs
Human Homolog GPR37, G protein-coupled receptor 37 (endothelin receptor type B-like)
NCBI Gene ID 2861
neXtProt AC  NX_O15354
Human Synonyms  EDNRBL, hET(B)R-LP, PAELR
Human Chr (Location)  7q31; chr7:124745601-124766025 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(1) Targeted(7)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene exhibit reduced striatal dopamine content, enhanced amphetamine sensitivity, reduced motor activity and coordination and increased percentage of body fat in females.
 
Interactions
Gpr37 interacts with 151 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Process dopamine biosynthetic process, G-protein coupled receptor signaling pathway, ...
Component endoplasmic reticulum, integral component of membrane, ...
Function G-protein coupled receptor activity, signal transducer activity
External Resources: FuncBase
Expression
Literature Summary: (6 records)
Data Summary: Results (211)    Tissues (111)    Images (99)
Theiler Stages: 19, 20, 22, 23, 24, 26, 28
Assay TypeResults
RNA in situ 129
In situ reporter (knock in) 44
RT-PCR 38
cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas
Molecular
reagents
All nucleic(27) Genomic(2) cDNA(23) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000039904 (Evidence)
Entrez Gene14763 (Evidence)
UniGene409670
DFCITC1578314, TC1743636
DoTSDT.485443, DT.94333194
NIA Mouse Gene IndexU027090
Consensus CDS ProjectCCDS19949.1
International Mouse Knockout Project StatusGpr37
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14763 NCBI Gene Model | MGI Sequence Detail 21458 C57BL/6J ±  kb
transcript NM_010338 RefSeq | MGI Sequence Detail 3205 Not Specified 
polypeptide Q9QY42 UniProt | EBI | MGI Sequence Detail 600 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms PCR(1) : SNPs within 2kb(146 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR003909 G protein-coupled receptor 37 orphan
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001148 G-protein coupled receptor 37
Graphical View of Protein Domain Structure
References (Earliest) J:45742 Marazziti D, et al., Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis. Genomics. 1998 NOV 1;53(3):315-324
(Latest) J:194542 Ghai R, et al., Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins. Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):E643-52
All references(39)
Other
accession IDs
MGI:2141499

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory