Gpr37
Gene Detail

Symbol

Name
ID

Gpr37
G protein-coupled receptor 37
MGI:1313297

Synonyms

Pael-R, parkin-associated endothelin B-like receptor

Feature Type

protein coding gene

Genetic Map

Chromosome 6
11.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr6:25668523-25689980 bp, - strand From NCBI annotation of GRCm38   21458 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate
homology

HomoloGene:3875  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: endothelin B receptor-like protein
Gene Tree: Gpr37

Human
homologs

Human Homolog		GPR37, G protein-coupled receptor 37 (endothelin receptor type B-like)
NCBI Gene ID		2861
neXtProt AC		NX_O15354
Human Synonyms		EDNRBL, hET(B)R-LP, PAELR
Human Chr (Location)		7q31; chr7:124745601-124766025 (-)  GRCh38

Mutations,
alleles, and
phenotypes

All mutations/alleles(10) : Gene trapped(1) Targeted(7) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 

Mice homozygous for disruptions in this gene exhibit reduced striatal dopamine content, enhanced amphetamine sensitivity, reduced motor activity and coordination and increased percentage of body fat in females.

 
Mutations Annotated to Human Diseases (2)   

Interactions

Gpr37 interacts with 151 markers (Mir7-1, Mir7-2, Mir7b, ...)

View All

Gene Ontology
(GO)
classifications

All GO classifications: (25 annotations)

Process	adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, dopamine biosynthetic process, ...
Component	endoplasmic reticulum, integral component of membrane, ...
Function	G-protein coupled peptide receptor activity, G-protein coupled receptor activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)

Data Summary: Results (211)    Tissues (112)    Images (99)    Tissue x Stage Matrix (view)

Assay Type	Results
RNA in situ	129
In situ reporter (knock in)	44
RT-PCR	38

cDNA source data(21)
External Resources: Allen Institute   GENSAT   GEO   Expression Atlas

Molecular
reagents

All nucleic(27) Genomic(2) cDNA(23) Primer pair(2)
Microarray probesets(3)

Other database
links

Ensembl Gene Model	ENSMUSG00000039904 (Evidence)
Entrez Gene	14763 (Evidence)
UniGene	409670
DFCI	TC1578314, TC1743636
DoTS	DT.94333194, DT.485443
NIA Mouse Gene Index	U027090
Consensus CDS Project	CCDS19949.1
International Mouse Knockout Project Status	Gpr37

Sequences

Length	Strain/Species
genomic	14763	NCBI Gene Model | MGI Sequence Detail	21458	C57BL/6J
transcript	NM_010338	RefSeq | MGI Sequence Detail	3205	Not Specified
polypeptide	Q9QY42	UniProt | EBI | MGI Sequence Detail	600	Not Applicable

All sequences(23) RefSeq(2) UniProt(1)

Polymorphisms

PCR(1) : SNPs within 2kb(146 from dbSNP Build 137)

Protein-related
information

Resource	ID	Description
InterPro	IPR017452	GPCR, rhodopsin-like, 7TM
InterPro	IPR003909	G protein-coupled receptor 37 orphan
InterPro	IPR000276	G protein-coupled receptor, rhodopsin-like
Protein Ontology	PR:000001148	G-protein coupled receptor 37

Graphical View of Protein Domain Structure

References

(Earliest) J:45742 Marazziti D, et al., Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis. Genomics. 1998 NOV 1;53(3):315-324
(Latest) J:211935 Dorval V, et al., Gene and MicroRNA transcriptome analysis of Parkinson's related LRRK2 mouse models. PLoS One. 2014;9(1):e85510
All references(43)

Other
accession IDs

MGI:2141499