Gpr37 MGI Mouse Gene Detail - MGI:1313297 - G protein-coupled receptor 37

Gpr37 Gene Detail

Symbol

Gpr37
Name

G protein-coupled receptor 37
Synonyms

Pael-R, parkin-associated endothelin B-like receptor

Feature Type

protein coding gene
IDs

MGI:1313297
NCBI Gene: 14763
Gene Overview

MyGene.info: GPR37

Sequence Map

Chr6:25665878-25690729 bp, - strand
From VEGA annotation of GRCm38

Mouse Genome Browser
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Sequence

24852 bp ± kb flank
Genome Browsers

VEGA | Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 11.65 cM
Mapping Data

4 experiments

Human Ortholog

GPR37, G protein-coupled receptor 37

Vertebrate Orthologs

9

Human Ortholog

GPR37, G protein-coupled receptor 37
Orthology source: HomoloGene, HGNC
Synonyms

EDNRBL, hET(B)R-LP, PAELR
Links

HGNC:4494

NCBI Gene ID: 2861

neXtProt AC: NX_O15354

UniProt: O15354
Chr Location

7q31.33; chr7:124745601-124766025 (-) GRCh38.p7

HomoloGene

Vertebrate Homology Class 3875
1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 macaque, rhesus
HCOP

human homology predictions: GPR37
Protein SuperFamily

endothelin B receptor-like protein
Gene Tree

Gpr37

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Mutations/Alleles

2 with disease annotations

References

1 with disease annotations

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Phenotype Summary

12 phenotypes from 4 alleles in 3 genetic backgrounds
14 phenotypes from multigenic genotypes
15 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

10
Gene trapped

1
Targeted

7
Transgenic

2
Incidental Mutations

Mutagenetix , APF
Find Mice (IMSR)

18 strains or lines available

Mice homozygous for disruptions in this gene exhibit reduced striatal dopamine content, enhanced amphetamine sensitivity, reduced motor activity and coordination and increased percentage of body fat in females.

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All GO Annotations

26
GO References

6

External Resources

FuncBase

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	receptor	receptor binding	RNA binding	transcription	transferase	transporter

Biological Process

nucleic acid-templated transcription	carbohydrate derivative metabolism	cell death	cell differentiation	cell proliferation	cellular component organization	establishment of localization	homeostatic process	immune system process	lipid metabolic process	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	non-membrane-bounded organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

211
Tissues

112
cDNA Data

21
Literature Summary

10

Images

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA GPR37

Xenbase gpr37

ZFIN gpr37b

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Gpr37 interacts with 151 markers (Mir7-1, Mir7-2, Mir7b, ...) View All

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All Sequences

25
RefSeq

2
UniProt

1
CCDS

CCDS19949.1
UniGene

409670

			Length	Strain/Species	Flank
genomic	OTTMUSG00000056018	VEGA Gene Model \| MGI Sequence Detail	24852	C57BL/6J	± kb
transcript	OTTMUST00000138552	VEGA \| MGI Sequence Detail	4974	Not Applicable
polypeptide	OTTMUSP00000072825	VEGA \| MGI Sequence Detail	600	Not Applicable

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SNPs within 2kb

154 from dbSNP Build 142

PCR

1

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UniProt

1 Sequence
Protein Ontology

PR:000001148 G-protein coupled receptor 37

(term hierarchy)
InterPro Domains

IPR017452 GPCR, rhodopsin-like, 7TM

IPR003909 G protein-coupled receptor 37 orphan

IPR000276 G protein-coupled receptor, rhodopsin-like

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All nucleic 27

Genomic 2

cDNA 23

Primer pair 2

Microarray probesets 3

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MGI:2141499

Summaries

All 47

Developmental Gene Expression 10

Diseases 1

Gene Ontology 6

Phenotypes 15
Earliest

J:45742 Marazziti D, et al., Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis. Genomics. 1998 NOV 1;53(3):315-324
Latest

J:241442 Rial D, et al., Parkinson's disease-associated GPR37 receptor regulates cocaine-mediated synaptic depression in corticostriatal synapses. Neurosci Lett. 2017 Jan 18;638:162-166

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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