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Gpr37 Gene Detail
Summary
  • Symbol
    Gpr37
  • Name
    G protein-coupled receptor 37
  • Synonyms
    Pael-R, parkin-associated endothelin B-like receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313297
    NCBI Gene: 14763
  • Gene Overview
    MyGene.info: GPR37
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr6:25665878-25690729 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      24852 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 11.65 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GPR37, G protein-coupled receptor 37
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPR37, G protein-coupled receptor 37
    Orthology source: HGNC, HomoloGene
  • Synonyms
    EDNRBL, hET(B)R-LP, PAELR
  • Links
    NCBI Gene ID: 2861
    neXtProt AC: NX_O15354
    UniProt: O15354

  • Chr Location
    7q31.33; chr7:124745601-124766025 (-)  GRCh38.p7

Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit reduced striatal dopamine content, enhanced amphetamine sensitivity, reduced motor activity and coordination and increased percentage of body fat in females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000056018 VEGA Gene Model | MGI Sequence Detail 24852 C57BL/6J ±  kb
    transcript OTTMUST00000138552 VEGA | MGI Sequence Detail 4974 Not Applicable  
    polypeptide OTTMUSP00000072825 VEGA | MGI Sequence Detail 600 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      154 from dbSNP Build 142
    • PCR
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 2
      cDNA 24
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141499
    References
    more
    • Summaries
      All 53
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 6
      Phenotypes 18
    • Earliest
      J:45742 Marazziti D, et al., Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis. Genomics. 1998 NOV 1;53(3):315-324
    • Latest
      J:260247 Giddens MM, et al., GPR37L1 modulates seizure susceptibility: Evidence from mouse studies and analyses of a human GPR37L1 variant. Neurobiol Dis. 2017 Oct;106:181-190

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    09/11/2018
    MGI 6.12
    The Jackson Laboratory