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Gpr37
Gene Detail
Symbol

Name
ID
Gpr37
G protein-coupled receptor 37
MGI:1313297
Synonyms
Pael-R, parkin-associated endothelin B-like receptor
Feature Type
protein coding gene
Genetic Map
Chromosome 6
11.65 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr6:25668523-25689980 bp, - strand
From NCBI annotation of GRCm38

  21458 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3875  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

HCOP human homology predictions: GPR37
Protein SuperFamily: endothelin B receptor-like protein
Gene Tree: Gpr37

Human
homologs
GPR37, G protein-coupled receptor 37 (endothelin receptor type B-like)
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 2861
neXtProt AC: NX_O15354

Human Synonyms: EDNRBL, hET(B)R-LP, PAELR

Human Chr (Location): 7q31; chr7:124745601-124766025 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(10) : Gene trapped(1) Targeted(7) Transgenic(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for disruptions in this gene exhibit reduced striatal dopamine content, enhanced amphetamine sensitivity, reduced motor activity and coordination and increased percentage of body fat in females.
 
Mutations Annotated to Human Diseases (2)   
Interactions
Gpr37 interacts with 151 markers (Mir7-1, Mir7-2, Mir7b, ...)
Expression
Literature Summary: (8 records)
Data Summary: Results (211)    Tissues (112)    Images (99)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 129
In situ reporter (knock in) 44
RT-PCR 38
cDNA source data(21)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA GPR37 ; Xenbase gpr37 ; ZFIN gpr37b    NEW 
Molecular
reagents
All nucleic(27) Genomic(2) cDNA(23) Primer pair(2)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000039904 (Evidence)
Entrez Gene 14763 (Evidence)
UniGene 409670
DFCI TC1743636, TC1578314
DoTS DT.94333194, DT.485443
NIA Mouse Gene Index U027090
Consensus CDS Project CCDS19949.1
International Mouse Phenotyping Consortium Status Gpr37
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 14763 NCBI Gene Model | MGI Sequence Detail 21458 C57BL/6J ±  kb
transcript NM_010338 RefSeq | MGI Sequence Detail 3205 Not Specified 
polypeptide Q9QY42 UniProt | EBI | MGI Sequence Detail 600 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(2) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(146 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017452 GPCR, rhodopsin-like, 7TM
InterPro IPR003909 G protein-coupled receptor 37 orphan
InterPro IPR000276 G protein-coupled receptor, rhodopsin-like
Protein Ontology PR:000001148 G-protein coupled receptor 37
Graphical View of Protein Domain Structure
References
(Earliest) J:45742 Marazziti D, et al., Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis. Genomics. 1998 NOV 1;53(3):315-324
(Latest) J:220996 La Sala G, et al., Modulation of Dhh signaling and altered Sertoli cell function in mice lacking the GPR37-prosaposin receptor. FASEB J. 2015 May;29(5):2059-69
All references(43)
Other
accession IDs
MGI:2141499

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
07/28/2015
MGI 5.22
The Jackson Laboratory