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Gpr37 Gene Detail
Summary
  • Symbol
    Gpr37
  • Name
    G protein-coupled receptor 37
  • Synonyms
    Pael-R, parkin-associated endothelin B-like receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313297
    NCBI Gene: 14763
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:25668522-25689979 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 11.65 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    659 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1313297
 protein coding gene Chr6:25665877-25690728 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030503
 protein coding gene Chr6:23258321-23282999 (-)
A/J MGP_AJ_G0030476
 protein coding gene Chr6:22282247-22307067 (-)
AKR/J MGP_AKRJ_G0030403
 protein coding gene Chr6:23034014-23058769 (-)
BALB/cJ MGP_BALBcJ_G0030486
 protein coding gene Chr6:22423673-22448436 (-)
C3H/HeJ MGP_C3HHeJ_G0030199
 protein coding gene Chr6:23012141-23038185 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030940
 protein coding gene Chr6:23967551-23992339 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028151
 protein coding gene Chr6:20647097-20672248 (-)
CAST/EiJ MGP_CASTEiJ_G0029601
 protein coding gene Chr6:22806251-22833029 (-)
CBA/J MGP_CBAJ_G0030177
 protein coding gene Chr6:24797649-24825332 (-)
DBA/2J MGP_DBA2J_G0030321
 protein coding gene Chr6:22264107-22288857 (-)
FVB/NJ MGP_FVBNJ_G0030275
 protein coding gene Chr6:22004108-22028839 (-)
LP/J MGP_LPJ_G0030408
 protein coding gene Chr6:23391048-23416811 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030311
 protein coding gene Chr6:26841960-26878747 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030970
 protein coding gene Chr6:22930450-22955245 (-)
PWK/PhJ MGP_PWKPhJ_G0029315
 protein coding gene Chr6:21770600-21796689 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029151
 protein coding gene Chr6:22614398-22637582 (-)
WSB/EiJ MGP_WSBEiJ_G0029677
 protein coding gene Chr6:22881242-22909120 (-)



Homology
more
  • Human Ortholog
    GPR37, G protein-coupled receptor 37
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPR37, G protein-coupled receptor 37
  • Synonyms
    EDNRBL, hET(B)R-LP, PAELR
  • Links
    NCBI Gene ID: 2861
    UniProt: O15354

  • Chr Location
    7q31.33; chr7:124743885-124765792 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 3 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene exhibit reduced striatal dopamine content, enhanced amphetamine sensitivity, reduced motor activity and coordination and increased percentage of body fat in females.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    66
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    933
  • Tissues
    117
  • cDNA Data
    22
  • Literature Summary
    12
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14763 NCBI Gene Model | MGI Sequence Detail 21458 C57BL/6J ±  kb
    transcript NM_010338 RefSeq | MGI Sequence Detail 3205 Not Specified  
    polypeptide Q9QY42 UniProt | EBI | MGI Sequence Detail 600 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 29
      Genomic 2
      cDNA 24
      Primer pair 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2141499
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 12
      Gene Ontology 11
      Phenotypes 33
    • Earliest
      J:45742 Marazziti D, et al., Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis. Genomics. 1998 NOV 1;53(3):315-324
    • Latest
      J:363965 Ma Q, et al., Oligodendrocytes drive neuroinflammation and neurodegeneration in Parkinson's disease via the prosaposin-GPR37-IL-6 axis. Cell Rep. 2025 Feb 25;44(2):115266
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    03/25/2025
    MGI 6.24     		The Jackson Laboratory