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Gpr37 Gene Detail
Summary
  • Symbol
    Gpr37
  • Name
    G protein-coupled receptor 37
  • Synonyms
    Pael-R, parkin-associated endothelin B-like receptor
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313297
    NCBI Gene: 14763
  • Gene Overview
    MyGene.info: GPR37
Location & Maps
more
  • Sequence Map
    Chr6:25665878-25690729 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser
  • Download
    Sequence
      24852 bp   ±  kb flank

  • Genome Browsers
    VEGA | Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 11.65 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    GPR37, G protein-coupled receptor 37
  • Vertebrate Orthologs
    9
  • Human Ortholog
    GPR37, G protein-coupled receptor 37
    Orthology source: HomoloGene, HGNC
  • Synonyms
    EDNRBL, hET(B)R-LP, PAELR
  • Links
    NCBI Gene ID: 2861
    neXtProt AC: NX_O15354

  • Chr Location
    7q31; chr7:124745601-124766025 (-)  GRCh38.p2
Human Diseases
less
  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 4 alleles in 3 genetic backgrounds
    14 phenotypes from multigenic genotypes
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    10
  • Gene trapped
    1
  • Targeted
    7
  • Transgenic
    2
  • Incidental Mutations
    Mutagenetix , APF
Mice homozygous for disruptions in this gene exhibit reduced striatal dopamine content, enhanced amphetamine sensitivity, reduced motor activity and coordination and increased percentage of body fat in females.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    26
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    211
  • Tissues
    112
  • cDNA Data
    21
  • Literature Summary
    8
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000056018 VEGA Gene Model | MGI Sequence Detail 24852 C57BL/6J ±  kb
transcript OTTMUST00000138552 VEGA | MGI Sequence Detail 4974 Not Applicable  
polypeptide OTTMUSP00000072825 VEGA | MGI Sequence Detail 600 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    154 from dbSNP Build 142
  • PCR
    1
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000001148 G-protein coupled receptor 37
  • InterPro Domains
    IPR017452 GPCR, rhodopsin-like, 7TM
    IPR003909 G protein-coupled receptor 37 orphan
    IPR000276 G protein-coupled receptor, rhodopsin-like
Molecular
Reagents
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  • All nucleic 27
    Genomic 2
    cDNA 23
    Primer pair 2

    Microarray probesets 3
Other
Accession IDs
less
MGI:2141499
References
more
  • Summaries
    All 43
    Developmental Gene Expression 8
    Diseases 1
    Gene Ontology 6
    Phenotypes 14
  • Earliest
    J:45742 Marazziti D, et al., Molecular cloning and chromosomal localization of the mouse Gpr37 gene encoding an orphan G-protein-coupled peptide receptor expressed in brain and testis. Genomics. 1998 NOV 1;53(3):315-324
  • Latest
    J:227153 Gandia J, et al., Adenosine A2A receptor-mediated control of pilocarpine-induced tremulous jaw movements is Parkinson's disease-associated GPR37 receptor-dependent. Behav Brain Res. 2015 Jul 15;288:103-6
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
09/13/2016
MGI 6.05 		The Jackson Laboratory