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Vezf1
Gene Detail
Symbol

Name
ID
Vezf1
vascular endothelial zinc finger 1
MGI:1313291
Synonyms
db1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
52.40 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr11:88068279-88084729 bp, + strand
From VEGA annotation of GRCm38

  16451 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:5175  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Gene Tree: Vezf1

Human
homologs
Human Homolog VEZF1, vascular endothelial zinc finger 1
NCBI Gene ID 7716
neXtProt AC  NX_Q14119
Human Synonyms  DB1, ZNF161
Human Chr (Location)  17q22; chr17:57971547-57988254 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(9) : Gene trapped(3) Targeted(6)
Genomic Mutations involving Vezf1 (2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice die at midgestation due to angiogenic remodeling defects and loss of vascular integrity leading to hemorrhaging in the head, heart and trunk. One fifth of heterozygous null embryos show lymphatic hypervascularization associated with hemorrhaging and edema in the jugular region.
 
Alleles Annotated to Human Diseases(1)   
Interactions
Vezf1 interacts with 438 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (3 annotations)
Process angiogenesis, endothelial cell development
Component nucleus
External Resources: FuncBase
Expression
Literature Summary: (13 records)
Data Summary: Results (163)    Tissues (154)    Images (15)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 147
Western blot 6
RT-PCR 10
cDNA source data(142)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(148) cDNA(145) Primer pair(2) Other(1)
Microarray probesets(6)
Other database
links
VEGA Gene ModelOTTMUSG00000001479 (Evidence)
Ensembl Gene ModelENSMUSG00000018377 (Evidence)
Entrez Gene22344 (Evidence)
UniGene46628
DFCITC1575953
DoTSDT.491895, DT.101376713
NIA Mouse Gene IndexU043211
Consensus CDS ProjectCCDS48880.1
International Mouse Knockout Project StatusVezf1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001479 VEGA Gene Model | MGI Sequence Detail 16451 C57BL/6J ±  kb
transcript OTTMUST00000002924 VEGA | MGI Sequence Detail 4583 Not Applicable 
polypeptide OTTMUSP00000001423 VEGA | MGI Sequence Detail 518 Not Applicable 

For the selected sequences
All sequences(45) RefSeq(10) UniProt(8)
Polymorphisms
SNPs within 2kb(76 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000017287 vascular endothelial zinc finger 1
References
(Earliest) J:49955 Belaoussoff M, et al., Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo. Development. 1998 Dec;125(24):5009-18
(Latest) J:182019 Gowher H, et al., Vezf1 protein binding sites genome-wide are associated with pausing of elongating RNA polymerase II. Proc Natl Acad Sci U S A. 2012 Feb 14;109(7):2370-5
All references(47)
Other
accession IDs
MGI:2144299, MGI:2144482

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/11/2014
MGI 5.20
The Jackson Laboratory