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Vezf1 Gene Detail
Summary
  • Symbol
    Vezf1
  • Name
    vascular endothelial zinc finger 1
  • Synonyms
    db1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313291
    NCBI Gene: 22344
Location & Maps
more
  • Sequence Map
    Chr11:88068279-88084729 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      16451 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    VEZF1, vascular endothelial zinc finger 1
  • Vertebrate Orthologs
    11
  • Human Ortholog
    VEZF1, vascular endothelial zinc finger 1
    Orthology source: HomoloGene
  • Synonyms
    DB1, ZNF161
  • Links
    NCBI Gene ID: 7716
    neXtProt AC: NX_Q14119

  • Chr Location
    17q22; chr17:57971547-57988254 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 5175
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;2 zebrafish
  • HCOP
    human homology predictions: VEZF1
  • Gene Tree
Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Chemically induced (other)
    1
  • Gene trapped
    3
  • Targeted
    7
  • Genomic Mutations
    4 involving Vezf1
  • Incidental Mutations
Homozygous null mice die at midgestation due to angiogenic remodeling defects and loss of vascular integrity leading to hemorrhaging in the head, heart and trunk. One fifth of heterozygous null embryos show lymphatic hypervascularization associated with hemorrhaging and edema in the jugular region.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000001479 VEGA Gene Model | MGI Sequence Detail 16451 C57BL/6J ±  kb
transcript OTTMUST00000002924 VEGA | MGI Sequence Detail 4583 Not Applicable  
polypeptide OTTMUSP00000001423 VEGA | MGI Sequence Detail 518 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    1 from dbSNP Build 142
Protein
Information
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  • UniProt
    4 Sequences
  • InterPro Domains
    IPR007087 Zinc finger, C2H2
    IPR015880 Zinc finger, C2H2-like
    IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Molecular
Reagents
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  • All nucleic 148
    cDNA 145
    Primer pair 2
    Other 1

    Microarray probesets 6
Other
Accession IDs
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MGI:2144299, MGI:2144482
References
more
  • Summaries
    All 44
    Developmental Gene Expression 13
    Diseases 1
    Gene Ontology 2
    Phenotypes 17
  • Earliest
    J:49955 Belaoussoff M, et al., Hematopoietic induction and respecification of A-P identity by visceral endoderm signaling in the mouse embryo. Development. 1998 Dec;125(24):5009-18
  • Latest
    J:223501 Gerald D, et al., RhoB controls coordination of adult angiogenesis and lymphangiogenesis following injury by regulating VEZF1-mediated transcription. Nat Commun. 2013;4:2824

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory