About   Help   FAQ
Incenp
Gene Detail
 Symbol
Name
ID
Incenp
inner centromere protein
MGI:1313288
Synonyms 2700067E22Rik
Feature Type protein coding gene
Genetic Map
Chromosome 19
6.10 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr19:9872297-9899533 bp, - strand
From NCBI annotation of GRCm38

  27237 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:9624  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Gene Tree: Incenp

Human
homologs
Human Homolog INCENP, inner centromere protein antigens 135/155kDa
NCBI Gene ID 3619
neXtProt AC  NX_Q9NQS7
Human Chr (Location)  11q12.3; chr11:62123973-62153163 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(16) : Gene trapped(8) Targeted(8)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutant embryos die before E8.5. Embryonic cells exhibit abnormal nuclei and abberent mitosis.
 
Interactions
Incenp interacts with 87 markers (Mir18b, Mir22, Mir24-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell cycle, cell division, ...
Component central element, centromeric heterochromatin, ...
External Resources: FuncBase
Expression
Literature Summary: (4 records)
Data Summary: Results (34)    Tissues (3)    Images (22)
Theiler Stages: 23
Assay TypeResults
RNA in situ 34
cDNA source data(15)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(18) Genomic(1) cDNA(17)
Microarray probesets(7)
Other database
links
Ensembl Gene ModelENSMUSG00000024660 (Evidence)
Entrez Gene16319 (Evidence)
DFCITC1574759, TC1600579
DoTSDT.101153603, DT.87072711
NIA Mouse Gene IndexU038792
Consensus CDS ProjectCCDS37912.1
International Mouse Knockout Project StatusIncenp
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 16319 NCBI Gene Model | MGI Sequence Detail 27237 C57BL/6J ±  kb
transcript NM_016692 RefSeq | MGI Sequence Detail 3217 C57BL/6 
polypeptide Q9WU62 UniProt | EBI | MGI Sequence Detail 880 Not Applicable 

For the selected sequences
All sequences(48) RefSeq(14) UniProt(1)
Polymorphisms RFLP(2) : SNPs within 2kb(155 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR022006 Chromosome passenger complex (CPC) protein INCENP N-terminal
InterPro IPR005635 Inner centromere protein, ARK-binding domain
Protein Ontology PR:000009029 inner centromere protein
Graphical View of Protein Domain Structure
References (Earliest) J:50321 Fowler KJ, et al., Genetic mapping of mouse centromere protein (Incenp and Cenpe) genes. Cytogenet Cell Genet. 1998;82(1-2):67-70
(Latest) J:173575 Fernandez-Miranda G, et al., Genetic disruption of aurora B uncovers an essential role for aurora C during early mammalian development. Development. 2011 Jul;138(13):2661-72
All references(44)
Other
accession IDs
MGI:1919833, MGI:2147646, MGI:2147779

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
08/12/2014
MGI 5.19
The Jackson Laboratory