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Eif2b3
Gene Detail
 Symbol
Name
ID
Eif2b3
eukaryotic translation initiation factor 2B, subunit 3
MGI:1313286
Synonyms 1190002P15Rik
Feature Type protein coding gene
Genetic Map
Chromosome 4
53.41 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr4:117019402-117087306 bp, + strand
From VEGA annotation of GRCm38

  67905 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7005  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Eif2b3

Human
homologs
Human Homolog EIF2B3, eukaryotic translation initiation factor 2B, subunit 3 gamma, 58kDa
NCBI Gene ID 8891
neXtProt AC  NX_Q9NR50
Human Synonyms  EIF-2B, EIF2Bgamma
Human Chr (Location)  1p34.1; chr1:44850522-44986722 (-)  GRCh38
Disease Associations  (1) Diseases Associated with Human EIF2B3
Mutations,
alleles, and
phenotypes
All mutations/alleles(148) : Gene trapped(146) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Eif2b3 interacts with 300 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (19 annotations)
Process cellular response to stimulus, negative regulation of translational initiation in response to stress, ...
Component cytoplasm, eukaryotic translation initiation factor 2B complex
Function guanyl-nucleotide exchange factor activity, translation factor activity, nucleic acid binding, ...
This is a GO Consortium Reference Genome Project gene.
External Resources: FuncBase
Expression
Literature Summary: (1 records)
Data Summary: Results (41)    Tissues (28)    Images (13)
Theiler Stages: 19, 23, 28
Assay TypeResults
RNA in situ 41
cDNA source data(51)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(51) cDNA(51)
Microarray probesets(2)
Other database
links
VEGA Gene ModelOTTMUSG00000009780 (Evidence)
Ensembl Gene ModelENSMUSG00000028683 (Evidence)
Entrez Gene108067 (Evidence)
UniGene34612
DFCITC1582784, TC1604583, TC1631160, TC1647474, TC1650452
DoTSDT.101349020, DT.50316354, DT.55176237, DT.91284647, DT.91339609, DT.91569053, DT.97369329
NIA Mouse Gene IndexU004704
Consensus CDS ProjectCCDS18524.1, CCDS51279.1
International Mouse Knockout Project StatusEif2b3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000009780 VEGA Gene Model | MGI Sequence Detail 67905 C57BL/6J ±  kb
transcript OTTMUST00000022643 VEGA | MGI Sequence Detail 1555 Not Applicable 
polypeptide OTTMUSP00000010337 VEGA | MGI Sequence Detail 452 Not Applicable 

For the selected sequences
All sequences(62) RefSeq(8) UniProt(6)
Polymorphisms SNPs within 2kb(447 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR005835 Nucleotidyl transferase
InterPro IPR011004 Trimeric LpxA-like
Protein Ontology PR:000006964 translation initiation factor eIF-2B subunit gamma
References (Earliest) J:65060 Kawai J, et al., Functional annotation of a full-length mouse cDNA collection. Nature. 2001 Feb 8;409(6821):685-90
(Latest) J:153498 Diez-Roux G, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
All references(33)
Other
accession IDs
MGI:1916112

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/23/2014
MGI 5.19
The Jackson Laboratory