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Alcam
Gene Detail
Symbol

Name
ID
Alcam
activated leukocyte cell adhesion molecule
MGI:1313266
Synonyms
BEN, CD166, DM-GRASP, MGC:27910, MuSC, SC1
Feature Type
protein coding gene
Genetic Map
Chromosome 16
32.88 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr16:52248996-52454074 bp, - strand
From VEGA annotation of GRCm38

  205079 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1229  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 2 zebrafish

Protein SuperFamily: VVC2C2C2 Ig-like domain arrangement-containing protein
Gene Tree: Alcam

Human
homologs
Human Homolog ALCAM, activated leukocyte cell adhesion molecule
NCBI Gene ID 214
neXtProt AC  NX_Q13740
Human Synonyms  CD166, MEMD
Human Chr (Location)  3q13.1; chr3:105366713-105576913 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(2) : Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display abnormal motor neuron and retinal ganglion cell morphology and retinal dysplasia.
 
Interactions
Alcam interacts with 386 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (11 annotations)
Process axon guidance, cell adhesion, ...
Component axon, external side of plasma membrane, ...
Function protein binding
External Resources: FuncBase
Expression
Literature Summary: (32 records)
Data Summary: Results (359)    Tissues (121)    Images (76)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 351
RT-PCR 8
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(15) cDNA(12) Primer pair(2) Other(1)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000036124 (Evidence)
Ensembl Gene ModelENSMUSG00000022636 (Evidence)
Entrez Gene11658 (Evidence)
DFCITC1578226, TC1590570, TC1704295, TC1655587
DoTSDT.110740160, DT.87068718
NIA Mouse Gene IndexU037107
Consensus CDS ProjectCCDS37356.1
International Mouse Knockout Project StatusAlcam
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000036124 VEGA Gene Model | MGI Sequence Detail 205079 C57BL/6J ±  kb
transcript OTTMUST00000092838 VEGA | MGI Sequence Detail 6036 Not Applicable 
polypeptide OTTMUSP00000051383 VEGA | MGI Sequence Detail 583 Not Applicable 

For the selected sequences
All sequences(66) RefSeq(4) UniProt(13)
Polymorphisms
SNPs within 2kb(1132 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR013162 CD80-like, immunoglobulin C2-set
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR013106 Immunoglobulin V-set
Protein Ontology PR:000001106 CD166 molecule
References
(Earliest) J:19352 Kanki JP, et al., The molecular cloning and characterization of potential chick DM-GRASP homologs in zebrafish and mouse. J Neurobiol. 1994 Jul;25(7):831-45
(Latest) J:213747 Chitteti BR, et al., CD166 regulates human and murine hematopoietic stem cells and the hematopoietic niche. Blood. 2014 Jul 24;124(4):519-29
All references(70)
Other
accession IDs
MGI:2146511

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory