Alcam
Gene Detail

Symbol Name ID

Alcam activated leukocyte cell adhesion molecule MGI:1313266

Synonyms

BEN, CD166, DM-GRASP, MGC:27910, MuSC, SC1

Feature Type

protein coding gene

Genetic Map

Chromosome 16

32.88 cM, cytoband B5
Detailed Genetic Map ± 1 cM


Mapping data(3)

Sequence Map

Chr16:52248996-52454074 bp, - strand From VEGA annotation of GRCm38   205079 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:1229  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken

Protein SuperFamily: VVC2C2C2 Ig-like domain arrangement-containing protein
Gene Tree: Alcam

Human homologs

Human Homolog		ALCAM, activated leukocyte cell adhesion molecule
NCBI Gene ID		214
neXtProt AC		NX_Q13740
Human Synonyms		CD166, MEMD
Human Chr (Location)		3q13.1; chr3:105085557-105295757 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(2) : Targeted(2)
 

Homozygous null mice display abnormal motor neuron and retinal ganglion cell morphology and retinal dysplasia.

 

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Process	axon guidance, cell adhesion, ...
Component	axon, external side of plasma membrane, ...
Function	protein binding

External Resources: FuncBase

Expression

Literature Summary: (30 records)
Data Summary: Results (359)    Tissues (121)    Images (76)
Theiler Stages: 11, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26

Assay Type	Results
RNA in situ	351
RT-PCR	8

cDNA source data(11)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(15) cDNA(12) Primer pair(2) Other(1)
Microarray probesets(8)

Other database links

VEGA Gene Model	OTTMUSG00000036124 (Evidence)
Ensembl Gene Model	ENSMUSG00000022636 (Evidence)
Entrez Gene	11658 (Evidence)
DFCI	TC1578226, TC1590570, TC1655587, TC1704295
DoTS	DT.110740160, DT.87068718
NIA Mouse Gene Index	U037107
Consensus CDS Project	CCDS37356.1
International Mouse Knockout Project Status	Alcam

Sequences

Length	Strain/Species
genomic	OTTMUSG00000036124	VEGA Gene Model | MGI Sequence Detail	205079	C57BL/6J
transcript	OTTMUST00000092838	VEGA | MGI Sequence Detail	6036	Not Applicable
polypeptide	OTTMUSP00000051383	VEGA | MGI Sequence Detail	583	Not Applicable

All sequences(58) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(1033 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR013162	CD80-like, immunoglobulin C2-set
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR013106	Immunoglobulin V-set
Protein Ontology	PR:000001106	CD166 molecule

References

(Earliest) J:19352 Kanki JP, et al., The molecular cloning and characterization of potential chick DM-GRASP homologs in zebrafish and mouse. J Neurobiol. 1994 Jul;25(7):831-45
(Latest) J:185583 Metzakopian E, et al., Genome-wide characterization of Foxa2 targets reveals upregulation of floor plate genes and repression of ventrolateral genes in midbrain dopaminergic progenitors. Development. 2012 Jul;139(14):2625-34
All references(62)

Other accession IDs

MGI:2146511