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Clip2
Gene Detail
Symbol

Name
ID
Clip2
CAP-GLY domain containing linker protein 2
MGI:1313136
Synonyms
CLIP-115, Cyln2, WSCR4
Feature Type
protein coding gene
Genetic Map
Chromosome 5
74.63 cM, cytoband G
Detailed Genetic Map ± 1 cM


Mapping data(10)
Sequence Map
Chr5:134489386-134552434 bp, - strand
From Ensembl annotation of GRCm38

  63049 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:20718  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: CLIP2
Gene Tree: Clip2

Human
homologs
CLIP2, CAP-GLY domain containing linker protein 2
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 7461
neXtProt AC: NX_Q9UDT6

Human Synonyms: CLIP, CLIP-115, CYLN2, WBSCR3, WBSCR4, WSCR3, WSCR4

Human Chr (Location): 7q11.23; chr7:74289475-74405943 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(7) : Gene trapped(3) Targeted(4)
Genomic Mutations involving Clip2 (1)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous and heterozygous for disruptions in this gene display growth deficiency, brain abnormalities and hippocampal dysfunction and deficits in motor coordination.
 
Human Diseases Modeled in Mice Using Clip2 (1)    Mutations Annotated to Human Diseases (2)   
Interactions
Clip2 interacts with 165 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (15 annotations)
Component cytoplasm, cytoplasmic microtubule, ...
Function microtubule plus-end binding, protein binding
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (233)    Tissues (47)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 201
Northern blot 29
Western blot 3
cDNA source data(94)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: GEISHA CLIP2 ; Xenbase clip2    NEW 
Molecular
reagents
All nucleic(102) Genomic(6) cDNA(95) Primer pair(1)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000063146 (Evidence)
Entrez Gene 269713 (Evidence)
UniGene 255138
DFCI TC1577891, TC1597342, TC1603551
DoTS DT.101389926, DT.110640831, DT.91324914
NIA Mouse Gene Index U026801
Consensus CDS Project CCDS39309.1, CCDS39310.1
International Mouse Phenotyping Consortium Status Clip2
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000063146 Ensembl Gene Model | MGI Sequence Detail 63049 C57BL/6J ±  kb
transcript ENSMUST00000100647 Ensembl | MGI Sequence Detail 4995 Not Applicable 
polypeptide ENSMUSP00000098212 Ensembl | MGI Sequence Detail 1047 Not Applicable 

For the selected sequences
All sequences(46) RefSeq(6) UniProt(1)
Polymorphisms
PCR(1) : SNPs within 2kb(634 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000938 CAP Gly-rich domain
Protein Ontology PR:000005582 CAP-Gly domain-containing linker protein 2
References
(Earliest) J:45192 De Zeeuw CI, et al., CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodies. Neuron. 1997 Dec;19(6):1187-99
(Latest) J:194894 Couesnon A, et al., CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. Development. 2013 Apr;140(7):1583-93
All references(44)
Disease annotation references (1)
Other
accession IDs
MGI:1196304

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory