Clip2
Gene Detail

Symbol Name ID

Clip2 CAP-GLY domain containing linker protein 2 MGI:1313136

Synonyms

CLIP-115, Cyln2, WSCR4

Feature Type

protein coding gene

Genetic Map

Chromosome 5

74.63 cM, cytoband G
Detailed Genetic Map ± 1 cM


Mapping data(10)

Sequence Map

Chr5:134489386-134552434 bp, - strand From NCBI annotation of GRCm38   63049 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:20718  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Gene Tree: Clip2

Human homologs

Human Homolog		CLIP2, CAP-GLY domain containing linker protein 2
NCBI Gene ID		7461
neXtProt AC		NX_Q9UDT6
Human Synonyms		CLIP, CLIP-115, CYLN2, WBSCR3, WBSCR4, WSCR3, WSCR4
Human Chr (Location)		7q11.23; chr7:73703805-73820273 (+)  GRCh37.p10

Alleles and phenotypes

All alleles(6) : Targeted(3) Gene trapped(3)
 

Mice homozygous and heterozygous for disruptions in this gene display growth deficiency, brain abnormalities and hippocampal dysfunction and deficits in motor coordination.

 
Human Diseases Modeled Using Mouse Clip2 (1)    Alleles Annotated to Human Diseases(1)   

Gene Ontology (GO) classifications

All GO classifications: (9 annotations)

Component	cytoplasm, cytoplasmic microtubule, ...
Function	microtubule binding, microtubule plus-end binding, ...

External Resources: FuncBase

Expression

Literature Summary: (5 records)
Data Summary: Results (233)    Tissues (46)    Images (24)
Theiler Stages: 15, 17, 19, 20, 22, 23, 24, 28

Assay Type	Results
RNA in situ	201
Northern blot	29
Western blot	3

cDNA source data(95)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(103) Genomic(6) cDNA(96) Primer pair(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000063146 (Evidence)
Entrez Gene	269713 (Evidence)
UniGene	255138
DFCI	TC1577891, TC1597342, TC1603551
DoTS	DT.101389926, DT.110640831, DT.91324914
NIA Mouse Gene Index	U026801
Consensus CDS Project	CCDS39309.1, CCDS39310.1
International Mouse Knockout Project Status	Clip2

Sequences

Length	Strain/Species
genomic	269713	NCBI Gene Model | MGI Sequence Detail	63049	C57BL/6J
transcript	NM_009990	RefSeq | MGI Sequence Detail	4995	C57BL/6
polypeptide	Q9Z0H8	UniProt | EBI | MGI Sequence Detail	1047	Not Applicable

All sequences(44) RefSeq(4) UniProt(1)

Polymorphisms

PCR(1) : SNPs(375 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000938	CAP Gly-rich domain
Protein Ontology	PR:000005582	CAP-Gly domain-containing linker protein 2

Graphical View of Protein Domain Structure

References

(Earliest) J:45192 De Zeeuw CI, et al., CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodies. Neuron. 1997 Dec;19(6):1187-99
(Latest) J:194894 Couesnon A, et al., CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. Development. 2013 Apr;140(7):1583-93
All references(44)

Other accession IDs

MGI:1196304