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Clip2 Gene Detail
Summary
  • Symbol
    Clip2
  • Name
    CAP-GLY domain containing linker protein 2
  • Synonyms
    CLIP-115, Cyln2, WSCR4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1313136
    NCBI Gene: 269713
  • Gene Overview
    MyGene.info: CLIP2
Location & Maps
more
  • Sequence Map
    Chr5:134489383-134552434 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      63052 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 74.63 cM, cytoband G
  • Mapping Data
    10 experiments
Homology
more
  • Human Ortholog
    CLIP2, CAP-Gly domain containing linker protein 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    CLIP2, CAP-Gly domain containing linker protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CLIP, CLIP-115, CYLN2, WBSCR3, WBSCR4, WSCR3, WSCR4
  • Links
    NCBI Gene ID: 7461
    neXtProt AC: NX_Q9UDT6

  • Chr Location
    7q11.23; chr7:74289475-74405943 (+)  GRCh38.p2

Human Diseases
more
  • Diseases
    1 with Clip2 mouse models

Human Disease Mouse Models
       Williams-Beuren Syndrome; WBS   OMIM: 194050 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    4 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 2 alleles in 1 genetic background
    11 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Gene trapped
    3
  • Targeted
    5
  • Genomic Mutations
    2 involving Clip2
  • Incidental Mutations
Mice homozygous and heterozygous for disruptions in this gene display growth deficiency, brain abnormalities and hippocampal dysfunction and deficits in motor coordination.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000055745 VEGA Gene Model | MGI Sequence Detail 63052 C57BL/6J ±  kb
transcript OTTMUST00000137944 VEGA | MGI Sequence Detail 4994 Not Applicable  
polypeptide OTTMUSP00000072584 VEGA | MGI Sequence Detail 1047 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    634 from dbSNP Build 142
  • PCR
Protein
Information
less
  • UniProt
    1 Sequence
  • Protein Ontology
    PR:000005582 CAP-Gly domain-containing linker protein 2
  • InterPro Domains
    IPR028394 CAP-Gly domain-containing linker protein 2
    IPR000938 CAP Gly-rich domain
Molecular
Reagents
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  • All nucleic 102
    Genomic 6
    cDNA 95
    Primer pair 1

    Microarray probesets 3
Other
Accession IDs
less
MGI:1196304
References
more
  • Summaries
    All 42
    Developmental Gene Expression 5
    Diseases 4
    Gene Ontology 4
    Phenotypes 11
  • Earliest
    J:45192 De Zeeuw CI, et al., CLIP-115, a novel brain-specific cytoplasmic linker protein, mediates the localization of dendritic lamellar bodies. Neuron. 1997 Dec;19(6):1187-99
  • Latest
    J:194894 Couesnon A, et al., CLIPR-59: a protein essential for neuromuscular junction stability during mouse late embryonic development. Development. 2013 Apr;140(7):1583-93

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory