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Tagln2 Gene Detail
Summary
  • Symbol
    Tagln2
  • Name
    transgelin 2
  • Synonyms
    2700094C18Rik, Sm22B
  • Feature Type
    protein coding gene
  • IDs
    MGI:1312985
    NCBI Gene: 21346
  • Gene Overview
    MyGene.info: TAGLN2
  • Alliance
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:172500246-172507375 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 79.89 cM
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    46 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1312985
protein coding gene Chr1:172500047-172507380 (.)
129S1/SvImJ MGP_129S1SvImJ_G0016790
protein coding gene Chr1:178369255-178380036 (+)
A/J MGP_AJ_G0016769
protein coding gene Chr1:171080201-171089733 (+)
AKR/J MGP_AKRJ_G0016735
protein coding gene Chr1:176241481-176248807 (+)
BALB/cJ MGP_BALBcJ_G0016730
protein coding gene Chr1:171616400-171623935 (+)
C3H/HeJ MGP_C3HHeJ_G0016554
protein coding gene Chr1:176815432-176823667 (+)
C57BL/6NJ MGP_C57BL6NJ_G0017192
protein coding gene Chr1:184295407-184305052 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014898
protein coding gene Chr1:162770948-162778232 (+)
CAST/EiJ MGP_CASTEiJ_G0016134
protein coding gene Chr1:176184233-176192829 (+)
CBA/J MGP_CBAJ_G0016528
protein coding gene Chr1:190841260-190853768 (+)
DBA/2J MGP_DBA2J_G0016635
protein coding gene Chr1:170003908-170011458 (+)
FVB/NJ MGP_FVBNJ_G0016632
protein coding gene Chr1:168260734-168269306 (+)
LP/J MGP_LPJ_G0016706
protein coding gene Chr1:179454058-179462036 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016659
protein coding gene Chr1:198075683-198083033 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0017228
protein coding gene Chr1:176112202-176119543 (+)
PWK/PhJ MGP_PWKPhJ_G0015920
protein coding gene Chr1:169385435-169393662 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015702
protein coding gene Chr1:175068340-175075598 (+)
WSB/EiJ MGP_WSBEiJ_G0016196
protein coding gene Chr1:176263987-176271933 (+)



Homology
more
  • Human Ortholog
    TAGLN2, transgelin 2
  • Vertebrate Orthologs
    9
  • Human Ortholog
    TAGLN2, transgelin 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HA1756
  • Links
    NCBI Gene ID: 8407
    neXtProt AC: NX_P37802
    UniProt: P37802

  • Chr Location
    1q23.2; chr1:159918107-159925542 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    9 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele display abnormalities in T cell physiology including cytotoxicity.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 21346 NCBI Gene Model | MGI Sequence Detail 7130 C57BL/6J ±  kb
transcript NM_178598 RefSeq | MGI Sequence Detail 1382 C57BL/6  
polypeptide Q9WVA4 UniProt | EBI | MGI Sequence Detail 199 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 267
    Genomic 23
    cDNA 243
    Primer pair 1

    Microarray probesets 6
Other
Accession IDs
less
MGI:1925645
References
more
  • Summaries
    All 42
    Developmental Gene Expression 7
    Gene Ontology 1
    Phenotypes 9
  • Earliest
    J:49043 Stanier P, et al., Paralogous sm22alpha (Tagln) genes map to mouse chromosomes 1 and 9: further evidence for a paralogous relationship. Genomics. 1998 Jul 1;51(1):144-7
  • Latest
    J:256571 Kim HR, et al., An Essential Role for TAGLN2 in Phagocytosis of Lipopolysaccharide-activated Macrophages. Sci Rep. 2017 Aug 18;7(1):8731

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory