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Casp12
Gene Detail
 Symbol
Name
ID
Casp12
caspase 12
MGI:1312922
Feature Type protein coding gene
Genetic Map
Chromosome 9
2.46 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:5345430-5373032 bp, + strand
From VEGA annotation of GRCm38

  27603 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7654  Vertebrate Homology Class
1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog

Protein SuperFamily: caspase, interleukin-1 beta convertase type
Gene Tree: Casp12

Mutations,
alleles, and
phenotypes
All mutations/alleles(5) : Targeted(5)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mice for some mutations of this gene display resistance to ER stress-induced apoptosis.
 
Interactions
Casp12 interacts with 226 markers (Mir1a-1, Mir1a-2, Mir1b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process apoptotic process, endoplasmic reticulum unfolded protein response, ...
Component cytoplasm, cytosol, ...
Function cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (8 records)
Data Summary: Results (153)    Tissues (77)    Images (64)
Theiler Stages: 18, 21, 23, 25, 27, 28
Assay TypeResults
RNA in situ 2
In situ reporter (knock in) 108
RT-PCR 38
RNase protection 5
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(29) Genomic(1) cDNA(26) Primer pair(1) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000033710 (Evidence)
Ensembl Gene ModelENSMUSG00000025887 (Evidence)
Entrez Gene12364 (Evidence)
UniGene42163
DFCITC1581373, TC1595187, TC1614323
DoTSDT.101222372, DT.101362409, DT.103566015, DT.40156590, DT.91438833, DT.94191968
NIA Mouse Gene IndexU010014
EC3.4.22.-
Consensus CDS ProjectCCDS22800.1
International Mouse Knockout Project StatusCasp12
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000033710 VEGA Gene Model | MGI Sequence Detail 27603 C57BL/6J ±  kb
transcript OTTMUST00000084913 VEGA | MGI Sequence Detail 2649 Not Applicable 
polypeptide OTTMUSP00000045800 VEGA | MGI Sequence Detail 419 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(4) UniProt(7)
Polymorphisms SNPs within 2kb(282 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR017350 Caspase, interleukin-1 beta convertase
InterPro IPR001315 Caspase Recruitment
InterPro IPR011029 Death-like domain
InterPro IPR011600 Peptidase C14, caspase catalytic
InterPro IPR002138 Peptidase C14, caspase non-catalytic subunit p10
InterPro IPR015917 Peptidase C14, caspase precursor p45, core
InterPro IPR001309 Peptidase C14, ICE, catalytic subunit p20
InterPro IPR016129 Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology PR:000034959 caspase-12
References (Earliest) J:38326 Van de Craen M, et al., Characterization of seven murine caspase family members. FEBS Lett. 1997 Feb 10;403(1):61-9
(Latest) J:191588 Mockel A, et al., Pharmacological modulation of the retinal unfolded protein response in Bardet-Biedl syndrome reduces apoptosis and preserves light detection ability. J Biol Chem. 2012 Oct 26;287(44):37483-94
All references(56)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
09/09/2014
MGI 5.19
The Jackson Laboratory