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Casp12 Gene Detail
Summary
  • Symbol
    Casp12
  • Name
    caspase 12
  • Feature Type
    protein coding gene
  • IDs
    MGI:1312922
    NCBI Gene: 12364
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:5345442-5373034 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 2.46 cM, cytoband A1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    260 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1312922
protein coding gene Chr9:5345430-5373034 (.)
129S1/SvImJ MGP_129S1SvImJ_G0034314
protein coding gene Chr9:2118808-2146204 (+)
A/J MGP_AJ_G0034291
protein coding gene Chr9:2214381-2241629 (+)
AKR/J MGP_AKRJ_G0034221
protein coding gene Chr9:2074856-2097436 (+)
BALB/cJ MGP_BALBcJ_G0034285
protein coding gene Chr9:2008273-2033533 (+)
C3H/HeJ MGP_C3HHeJ_G0033997
protein coding gene Chr9:2276828-2301264 (+)
C57BL/6NJ MGP_C57BL6NJ_G0034807
protein coding gene Chr9:2257526-2283865 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0031745
protein coding gene Chr9:1753575-1775182 (+)
CAST/EiJ MGP_CASTEiJ_G0033324
protein coding gene Chr9:2308509-2330558 (+)
CBA/J MGP_CBAJ_G0033969
protein coding gene Chr9:2235784-2258282 (+)
DBA/2J MGP_DBA2J_G0034126
protein coding gene Chr9:2194237-2218929 (+)
FVB/NJ MGP_FVBNJ_G0034071
protein coding gene Chr9:2003702-2026162 (+)
LP/J MGP_LPJ_G0034213
protein coding gene Chr9:2129176-2151474 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0034115
protein coding gene Chr9:2739559-2769398 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0034826
protein coding gene Chr9:2082168-2109672 (+)
PWK/PhJ MGP_PWKPhJ_G0033028
protein coding gene Chr9:2315843-2340269 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032865
protein coding gene Chr9:2377241-2398371 (+)
WSB/EiJ MGP_WSBEiJ_G0033440
protein coding gene Chr9:2107302-2137781 (+)



Homology
more
  • Human Ortholog
    CASP12, caspase 12 (gene/pseudogene)
  • Vertebrate Orthologs
    5
  • Human Ortholog
    CASP12, caspase 12 (gene/pseudogene)
    Orthology source: HGNC
  • Synonyms
    CASP-12, CASP12P1
  • Links
    NCBI Gene ID: 100506742
    neXtProt AC: NX_Q6UXS9
    UniProt: Q6UXS9

  • Chr Location
    chr11:104885718-104898670 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    12 phenotypes from 4 alleles in 4 genetic backgrounds
    3 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mice for some mutations of this gene display resistance to ER stress-induced apoptosis.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 12364 NCBI Gene Model | MGI Sequence Detail 27593 C57BL/6J ±  kb
    transcript NM_009808 RefSeq | MGI Sequence Detail 2605 C57BL/6  
    polypeptide O08736 UniProt | EBI | MGI Sequence Detail 419 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      Genomic 1
      cDNA 27
      Primer pair 1
      Other 1

      Microarray probesets 4
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 8
      Gene Ontology 13
      Phenotypes 16
    • Earliest
      J:38326 Van de Craen M, et al., Characterization of seven murine caspase family members. FEBS Lett. 1997 Feb 10;403(1):61-9
    • Latest
      J:240695 Diamanti MA, et al., IKKalpha controls ATG16L1 degradation to prevent ER stress during inflammation. J Exp Med. 2017 Feb;214(2):423-437

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/06/2018
    MGI 6.13
    The Jackson Laboratory