Casp12 MGI Mouse Gene Detail - MGI:1312922

Symbol

Casp12
Name

caspase 12

Feature Type

protein coding gene
IDs

MGI:1312922
NCBI Gene: 12364
Alliance

genome feature page
Transcription Start Sites

2 TSS

Sequence Map

Chr9:5345430-5373032 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 2.46 cM, cytoband A1
Mapping Data

2 experiments

SNPs within 2kb

791 from dbSNP Build 142
Strain Annotations

19

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_1312922	protein coding gene	Chr9:5345419-5373034 (+)
129S1/SvImJ	ENSMUSG00200022431	protein coding gene	Chr9:2175330-2203380 (+)
A/J	ENSMUSG00195019099	protein coding gene	Chr9:2104760-2132368 (+)
AKR/J	ENSMUSG00220018489	protein coding gene	Chr9:2241894-2269942 (+)
BALB/cJ	ENSMUSG00180011290	protein coding gene	Chr9:2245228-2272831 (+)
C3H/HeJ	ENSMUSG00175023930	protein coding gene	Chr9:2172748-2200355 (+)
C57BL/6NJ	ENSMUSG00215006558	protein coding gene	Chr9:2181094-2208697 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031745	protein coding gene	Chr9:1753575-1775182 (+)
CAST/EiJ	ENSTCUG00005007001	protein coding gene	Chr9:2267159-2288638 (+)
CBA/J	ENSMUSG00210010630	protein coding gene	Chr9:2116280-2136884 (+)
DBA/2J	ENSMUSG00185005023	protein coding gene	Chr9:2313314-2340921 (+)
FVB/NJ	ENSMUSG00205006731	protein coding gene	Chr9:2287348-2314951 (+)
JF1/MsJ	ENSUMUG00000008410	protein coding gene	Chr9:2308505-2330020 (+)
LP/J	ENSMUSG00230004354	protein coding gene	Chr9:2773249-2800852 (+)
NOD/ShiLtJ	ENSMUSG00190021486	protein coding gene	Chr9:2203497-2231101 (+)
NZO/HlLtJ	ENSMUSG00225016355	protein coding gene	Chr9:2652987-2680590 (+)
PWK/PhJ	ENSLUMG00010006340	protein coding gene	Chr9:2290683-2319355 (+)
SPRET/EiJ	ENSMSPG00010005276	protein coding gene	Chr9:2335981-2349460 (+)
WSB/EiJ	ENSIUOG00005007659	protein coding gene	Chr9:2090419-2121773 (+)

Human Ortholog

CASP12, caspase 12 (gene/pseudogene)

Vertebrate Orthologs

3

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

CASP12, caspase 12 (gene/pseudogene)
Synonyms

CASP-12, CASP12P1
Links

HGNC:19004

NCBI Gene ID: 100506742

UniProt: Q6UXS9
Chr Location

chr11:104883286-104898670 (-) GRCh38

MGI Vertebrate Homology

Casp12 stringent orthology
1 human;1 mouse;1 rat;1 zebrafish
HCOP

vertebrate homology predictions: CASP12
Protein SuperFamily

Caspase_ICE
Gene Tree

Casp12

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Phenotype Summary

11 phenotypes from 3 alleles in 3 genetic backgrounds
3 phenotypes from multigenic genotypes
23 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

7
Endonuclease-mediated

1
Targeted

6
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

32 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Homozygous mice for some mutations of this gene display resistance to ER stress-induced apoptosis.

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All GO Annotations

40
GO References

13

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

777
Tissues

101
cDNA Data

27
Literature Summary

11

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

56
RefSeq

8
UniProt

7
CCDS

CCDS22800.1

Ensembl

ENSMUSG00000025887 (Evidence)
NCBI Gene

12364

			Length	Strain/Species	Flank
genomic	ENSMUSG00000025887	Ensembl Gene Model \| MGI Sequence Detail	27603	C57BL/6J	± kb
transcript	ENSMUST00000027009	Ensembl \| MGI Sequence Detail	2649	Not Applicable
polypeptide	ENSMUSP00000027009	Ensembl \| MGI Sequence Detail	419	Not Applicable

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UniProt

7 Sequences
Protein Ontology

PR:000034959 caspase-12

(term hierarchy)
EC

3.4.22.-
InterPro Domains

IPR001315 CARD domain

IPR029030 Caspase-like domain superfamily

IPR011029 Death-like domain superfamily

IPR015917 Peptidase C14A, caspase catalytic domain

IPR011600 Peptidase C14, caspase domain

IPR002138 Peptidase C14, caspase non-catalytic subunit p10

IPR002398 Peptidase C14 family

IPR001309 Peptidase C14, p20 domain

IPR033139 Peptidase family C14A, cysteine active site

IPR016129 Peptidase family C14A, His active site

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All nucleic 31

Genomic 1

cDNA 27

Primer pair 2

Other 1

Antibodies 1

Microarray probesets 4

Summaries

All 90

Developmental Gene Expression 11

Gene Ontology 13

Phenotypes 23
Earliest

J:38326 Van de Craen M, et al., Characterization of seven murine caspase family members. FEBS Lett. 1997 Feb 10;403(1):61-9
Latest

J:380714 Xu J, et al., Depletion of Caspase-12 Alleviates Retinal Degeneration in Aged BALB/c Mice Following Systemic Neonatal Infection by Murine Cytomegalovirus (MCMV). Viruses. 2025 Sep 3;17(9)

TSS for Casp12:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr83662	Chr9:5345414-5345435 (+)	-5 bp
Tssr83663	Chr9:5345450-5345505 (+)	48 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 09/01/2026 MGI 6.24