Casp12
Gene Detail

Symbol Name ID

Casp12 caspase 12 MGI:1312922

Feature Type

protein coding gene

Genetic Map

Chromosome 9

2.46 cM, cytoband A1
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:5345430-5373032 bp, + strand From VEGA annotation of GRCm38   27603 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; chimpanzee; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Casp12 ± 2 cM)

Protein SuperFamily: caspase, interleukin-1 beta convertase type
Gene Tree: Casp12

Human ortholog

CASP12 caspase 12 (gene/pseudogene) NCBI Gene ID 100506742
Human Synonyms: CASP-12, CASP12P1
Human Chr11:104756666-104769397 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(5) : Targeted(5)
 

Homozygous mice for some mutations of this gene display resistance to ER stress-induced apoptosis.

 

Gene Ontology (GO) classifications

All GO classifications: (24 annotations)

Process	apoptotic process, endoplasmic reticulum unfolded protein response, ...
Component	cytosol, endoplasmic reticulum, ...
Function	cysteine-type endopeptidase activity, cysteine-type peptidase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (7 records)
Data Summary: Results (151)    Tissues (75)    Images (62)
Theiler Stages: 18, 21, 23, 25, 28

Assay Type	Results
In situ reporter (knock in)	108
RT-PCR	38
RNase protection	5

cDNA source data(26)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(29) Genomic(1) cDNA(26) Primer pair(1) Other(1)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000033710 (Evidence)
Ensembl Gene Model	ENSMUSG00000025887 (Evidence)
Entrez Gene	12364 (Evidence)
UniGene	42163
DFCI	TC1581373, TC1595187, TC1614323
DoTS	DT.101222372, DT.101362409, DT.103566015, DT.40156590, DT.91438833, DT.94191968
NIA Mouse Gene Index	U010014
EC	3.4.22.-
Consensus CDS Project	CCDS22800.1
International Mouse Knockout Project Status	Casp12

Sequences

Length	Strain/Species
genomic	OTTMUSG00000033710	VEGA Gene Model | MGI Sequence Detail	27603	C57BL/6J
transcript	OTTMUST00000084913	VEGA | MGI Sequence Detail	2649	Not Applicable
polypeptide	OTTMUSP00000045800	VEGA | MGI Sequence Detail	419	Not Applicable

All sequences(50) RefSeq(2) UniProt(7)

Polymorphisms

SNPs(267 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR017350	Caspase, interleukin-1 beta convertase
InterPro	IPR001315	Caspase Recruitment
InterPro	IPR011029	DEATH-like
InterPro	IPR011600	Peptidase C14, caspase catalytic
InterPro	IPR002138	Peptidase C14, caspase non-catalytic subunit p10
InterPro	IPR002398	Peptidase C14, caspase precursor p45
InterPro	IPR015917	Peptidase C14, caspase precursor p45, core
InterPro	IPR001309	Peptidase C14, ICE, catalytic subunit p20
InterPro	IPR016129	Peptidase C14, ICE, catalytic subunit p20, active site
Protein Ontology	PR:000034959	caspase-12

References

(Earliest) J:38326 Van de Craen M, et al., Characterization of seven murine caspase family members. FEBS Lett. 1997 Feb 10;403(1):61-9
(Latest) J:191588 Mockel A, et al., Pharmacological modulation of the retinal unfolded protein response in Bardet-Biedl syndrome reduces apoptosis and preserves light detection ability. J Biol Chem. 2012 Oct 26;287(44):37483-94
All references(54)