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Casp6 Gene Detail
Summary
  • Symbol
    Casp6
  • Name
    caspase 6
  • Synonyms
    mCASP-6, Mch2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1312921
    NCBI Gene: 12368
  • Gene Overview
    MyGene.info: CASP6
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr3:129901425-129914103 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      12679 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 3, 59.50 cM, cytoband H1
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CASP6, caspase 6
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CASP6, caspase 6
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MCH2
  • Links
    NCBI Gene ID: 839
    neXtProt AC: NX_P55212
    UniProt: P55212

  • Chr Location
    4q25; chr4:109688629-109703473 (-)  GRCh38.p7

Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    5 phenotypes from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit failure to induce increased lysis of fluorogenic substrate VEID-AMC in staurosporine treated of lenses. Mice homozygous for a different knock-out allele exhibit resistance to excitotoxicity and axonal degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000028845 VEGA Gene Model | MGI Sequence Detail 12679 C57BL/6J ±  kb
    transcript OTTMUST00000071443 VEGA | MGI Sequence Detail 1456 Not Applicable  
    polypeptide OTTMUSP00000036607 VEGA | MGI Sequence Detail 276 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      230 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 82
      Genomic 1
      cDNA 78
      Primer pair 2
      Other 1

      Microarray probesets 3
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:38326 Van de Craen M, et al., Characterization of seven murine caspase family members. FEBS Lett. 1997 Feb 10;403(1):61-9
    • Latest
      J:257791 Woo V, et al., Caspase-6 is a Dispensable Enabler of Adult Mammalian Axonal Degeneration. Neuroscience. 2018 Feb 10;371:242-253

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
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    last database update
    07/31/2018
    MGI 6.12
    The Jackson Laboratory