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Kcnj15 Gene Detail
Summary
  • Symbol
    Kcnj15
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 15
  • Synonyms
    4930414N08Rik, IRKK, Kir4.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1310000
    NCBI Gene: 16516
  • Gene Overview
    MyGene.info: KCNJ15
  • Alliance
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:95257558-95300260 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 55.86 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    189 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1310000
protein coding gene Chr16:95257558-95300260 (.)
129S1/SvImJ MGP_129S1SvImJ_G0023075
protein coding gene Chr16:96550304-96594219 (+)
A/J MGP_AJ_G0023043
protein coding gene Chr16:91990091-92032465 (+)
AKR/J MGP_AKRJ_G0023013
protein coding gene Chr16:94807270-94849642 (+)
BALB/cJ MGP_BALBcJ_G0023045
protein coding gene Chr16:92535639-92579037 (+)
C3H/HeJ MGP_C3HHeJ_G0022806
protein coding gene Chr16:95338631-95383680 (+)
C57BL/6NJ MGP_C57BL6NJ_G0023492
protein coding gene Chr16:99607244-99649496 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0020994
protein coding gene Chr16:89857673-89902080 (+)
CAST/EiJ MGP_CASTEiJ_G0022325
protein coding gene Chr16:96114336-96159898 (+)
CBA/J MGP_CBAJ_G0022775
protein coding gene Chr16:103873257-103929218 (+)
DBA/2J MGP_DBA2J_G0022909
protein coding gene Chr16:91883481-91926448 (+)
FVB/NJ MGP_FVBNJ_G0022883
protein coding gene Chr16:91043904-91087179 (+)
LP/J MGP_LPJ_G0022979
protein coding gene Chr16:96185457-96231360 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0022904
protein coding gene Chr16:108199748-108246633 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0023510
protein coding gene Chr16:95345006-95389206 (+)
PWK/PhJ MGP_PWKPhJ_G0022070
protein coding gene Chr16:92160568-92204467 (+)
SPRET/EiJ MGP_SPRETEiJ_G0021900
protein coding gene Chr16:94872906-94918095 (+)
WSB/EiJ MGP_WSBEiJ_G0022376
protein coding gene Chr16:95616654-95658663 (+)



Homology
more
  • Human Ortholog
    KCNJ15, potassium voltage-gated channel subfamily J member 15
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNJ15, potassium voltage-gated channel subfamily J member 15
    Orthology source: HomoloGene, HGNC
  • Synonyms
    IRKK, KIR1.3, KIR4.2
  • Links
    NCBI Gene ID: 3772
    neXtProt AC: NX_Q99712
    UniProt: Q99712

  • Chr Location
    21q22.13-q22.2; chr21:38229915-38303126 (+)  GRCh38.p7

Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    27 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout mice exhibited impaired balance/coordination in a high-throughput screen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 16516 NCBI Gene Model | MGI Sequence Detail 42703 C57BL/6J ±  kb
transcript NR_073406 RefSeq | MGI Sequence Detail 5455 C57BL/6  
polypeptide O88932 UniProt | EBI | MGI Sequence Detail 375 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    10 Sequences
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR016449 Potassium channel, inwardly rectifying, Kir
    IPR003270 Potassium channel, inwardly rectifying, Kir1.3
    IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Molecular
Reagents
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  • All nucleic 37
    Genomic 2
    cDNA 30
    Primer pair 3
    Other 2

    Microarray probesets 8
Other
Accession IDs
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MGI:1921109, MGI:2146383, MGI:2146401
References
more
  • Summaries
    All 67
    Developmental Gene Expression 7
    Diseases 3
    Gene Ontology 7
    Phenotypes 27
  • Earliest
    J:43272 Gosset P, et al., A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1). Genomics. 1997 Sep 1;44(2):237-41
  • Latest
    J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory