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Kcnj15
Gene Detail
 Symbol
Name
ID
Kcnj15
potassium inwardly-rectifying channel, subfamily J, member 15
MGI:1310000
Synonyms 4930414N08Rik, IRKK, Kir4.2
Feature Type protein coding gene
Genetic Map
Chromosome 16
55.86 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr16:95257558-95300211 bp, + strand
From VEGA annotation of GRCm38

  42654 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:1690  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: G protein-activated inward rectifier potassium channel
Gene Tree: Kcnj15

Human
homologs
Human Homolog KCNJ15, potassium inwardly-rectifying channel, subfamily J, member 15
NCBI Gene ID 3772
neXtProt AC  NX_Q99712
Human Synonyms  IRKK, KIR1.3, KIR4.2
Human Chr (Location)  21q22.2; chr21:38229915-38303121 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(4) : Targeted(4)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous knockout mice exhibited impaired balance/coordination in a high-throughput screen.
 
Interactions
Kcnj15 interacts with 323 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (13 annotations)
Process ion transport, potassium ion transmembrane transport, ...
Component integral component of membrane, membrane, ...
Function inward rectifier potassium channel activity, potassium channel activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (285)    Tissues (190)    Images (32)
Theiler Stages: 13, 15, 17, 20, 22, 23, 25, 26, 27, 28
Assay TypeResults
RNA in situ 264
RT-PCR 21
cDNA source data(26)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(33) Genomic(2) cDNA(28) Primer pair(3)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000019964 (Evidence)
Ensembl Gene ModelENSMUSG00000062609 (Evidence)
Entrez Gene16516 (Evidence)
DFCITC1582160, TC1590125, TC1599280, TC1615613, TC1686027, TC1702811, TC1703758, TC1713728, TC1722423, TC1778893
DoTSDT.101407565, DT.110735964, DT.485848, DT.50316054, DT.87036445, DT.91369317, DT.91391149, DT.94379974, DT.94379977, DT.94379981, DT.97409508, DT.99604344
NIA Mouse Gene IndexU017414
Consensus CDS ProjectCCDS28351.1, CCDS37410.1
International Mouse Knockout Project StatusKcnj15
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019964 VEGA Gene Model | MGI Sequence Detail 42654 C57BL/6J ±  kb
transcript OTTMUST00000047567 VEGA | MGI Sequence Detail 5705 Not Applicable 
polypeptide OTTMUSP00000021534 VEGA | MGI Sequence Detail 402 Not Applicable 

For the selected sequences
All sequences(211) RefSeq(87) UniProt(10)
Polymorphisms SNPs within 2kb(190 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR014756 Immunoglobulin E-set
InterPro IPR016449 Potassium channel, inwardly rectifying, Kir
InterPro IPR003270 Potassium channel, inwardly rectifying, Kir1.3
InterPro IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Protein Ontology PR:000001983 ATP-sensitive inward rectifier potassium channel 15
References (Earliest) J:43272 Gosset P, et al., A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1). Genomics. 1997 Sep 1;44(2):237-41
(Latest) J:178022 He W, et al., Acid secretion-associated translocation of KCNJ15 in gastric parietal cells. Am J Physiol Gastrointest Liver Physiol. 2011 Oct;301(4):G591-600
All references(45)
Other
accession IDs
MGI:1921109, MGI:2146383, MGI:2146401

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory