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Kcnj15 Gene Detail
Summary
  • Symbol
    Kcnj15
  • Name
    potassium inwardly-rectifying channel, subfamily J, member 15
  • Synonyms
    4930414N08Rik, IRKK, Kir4.2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1310000
    NCBI Gene: 16516
  • Gene Overview
    MyGene.info: KCNJ15
Location & Maps
more
  • Sequence Map
    Chr16:95257558-95300211 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      42654 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 16, 55.86 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    KCNJ15, potassium voltage-gated channel subfamily J member 15
  • Vertebrate Orthologs
    10
  • Human Ortholog
    KCNJ15, potassium voltage-gated channel subfamily J member 15
    Orthology source: HGNC, HomoloGene
  • Synonyms
    IRKK, KIR1.3, KIR4.2
  • Links
    NCBI Gene ID: 3772
    neXtProt AC: NX_Q99712

  • Chr Location
    21q22.2; chr21:38229915-38303126 (+)  GRCh38.p2

Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    1 phenotype from 1 allele in 1 genetic background
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    8
  • Targeted
    8
  • Genomic Mutations
    4 involving Kcnj15
  • Incidental Mutations
Homozygous knockout mice exhibited impaired balance/coordination in a high-throughput screen.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000019964 VEGA Gene Model | MGI Sequence Detail 42654 C57BL/6J ±  kb
transcript OTTMUST00000047567 VEGA | MGI Sequence Detail 5705 Not Applicable  
polypeptide OTTMUSP00000021534 VEGA | MGI Sequence Detail 402 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    189 from dbSNP Build 142
Protein
Information
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  • UniProt
    10 Sequences
  • Protein Ontology
    PR:000001983 ATP-sensitive inward rectifier potassium channel 15
  • InterPro Domains
    IPR014756 Immunoglobulin E-set
    IPR016449 Potassium channel, inwardly rectifying, Kir
    IPR003270 Potassium channel, inwardly rectifying, Kir1.3
    IPR013518 Potassium channel, inwardly rectifying, Kir, cytoplasmic
Molecular
Reagents
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  • All nucleic 35
    Genomic 2
    cDNA 29
    Primer pair 3
    Other 1

    Microarray probesets 8
Other
Accession IDs
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MGI:1921109, MGI:2146383, MGI:2146401
References
more
  • Summaries
    All 42
    Developmental Gene Expression 7
    Diseases 3
    Gene Ontology 6
    Phenotypes 21
  • Earliest
    J:43272 Gosset P, et al., A new inward rectifier potassium channel gene (KCNJ15) localized on chromosome 21 in the Down syndrome chromosome region 1 (DCR1). Genomics. 1997 Sep 1;44(2):237-41
  • Latest
    J:178022 He W, et al., Acid secretion-associated translocation of KCNJ15 in gastric parietal cells. Am J Physiol Gastrointest Liver Physiol. 2011 Oct;301(4):G591-600

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory