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Prkx
Gene Detail
Symbol

Name
ID
Prkx
protein kinase, X-linked
MGI:1309999
Synonyms
Pkare
Feature Type
protein coding gene
Genetic Map
Chromosome X
38.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
ChrX:77761411-77796278 bp, - strand
From VEGA annotation of GRCm38

  34868 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:55868  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Prkx

Human
homologs
Human Homolog PRKX, protein kinase, X-linked
NCBI Gene ID 5613
neXtProt AC  NX_P51817
Human Synonyms  PKX1
Human Chr (Location)  Xp22.3; chrX:3604343-3713634 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(1) : Targeted(1)
Interactions
Prkx interacts with 309 markers (Mir1b, Mir7-1, Mir7-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (33 annotations)
Process angiogenesis, cell adhesion, ...
Component cytoplasm, nucleus
Function ATP binding, cAMP-dependent protein kinase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (32)    Tissues (28)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 32
cDNA source data(65)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(68) Genomic(1) cDNA(67)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000017860 (Evidence)
Ensembl Gene ModelENSMUSG00000035725 (Evidence)
Entrez Gene19108 (Evidence)
UniGene290338
DFCITC1780077, TC1574487
DoTSDT.97379079
NIA Mouse Gene IndexU039494
EC2.7.11.1
Consensus CDS ProjectCCDS30248.1
International Mouse Knockout Project StatusPrkx
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017860 VEGA Gene Model | MGI Sequence Detail 34868 C57BL/6J ±  kb
transcript OTTMUST00000043228 VEGA | MGI Sequence Detail 4146 Not Applicable 
polypeptide OTTMUSP00000019439 VEGA | MGI Sequence Detail 355 Not Applicable 

For the selected sequences
All sequences(42) RefSeq(6) UniProt(5)
Polymorphisms
SNPs within 2kb(84 from dbSNP Build 137)    SNPs within 2kb including multiple locations(86)
Protein-related
information
ResourceIDDescription
InterPro IPR000961 AGC-kinase, C-terminal
InterPro IPR017441 Protein kinase, ATP binding site
InterPro IPR000719 Protein kinase, catalytic domain
InterPro IPR011009 Protein kinase-like domain
InterPro IPR002290 Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro IPR008271 Serine/threonine-protein kinase, active site
InterPro IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology PR:000013244 serine/threonine-protein kinase PRKX
References
(Earliest) J:45217 Blaschke RJ, et al., Man to mouse--lessons learned from the distal end of the human X chromosome. Genome Res. 1997 Dec;7(12):1114-7
(Latest) J:177220 Li X, et al., PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation. Dev Biol. 2011 Aug 15;356(2):475-85
All references(28)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/18/2014
MGI 5.20
The Jackson Laboratory