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Prkx Gene Detail
Summary
  • Symbol
    Prkx
  • Name
    protein kinase, X-linked
  • Synonyms
    Pkare
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309999
    NCBI Gene: 19108
Location & Maps
more
  • Sequence Map
    ChrX:77761411-77796278 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      34868 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    PRKX, protein kinase, X-linked
  • Vertebrate Orthologs
    10
  • Human Ortholog
    PRKX, protein kinase, X-linked
    Orthology source: HGNC, HomoloGene
  • Synonyms
    PKX1
  • Links
    NCBI Gene ID: 5613
    neXtProt AC: NX_P51817

  • Chr Location
    Xp22.3; chrX:3604343-3713644 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotype references
  • All Mutations and Alleles
    2
  • Endonuclease-mediated
    1
  • Targeted
    1
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017860 VEGA Gene Model | MGI Sequence Detail 34868 C57BL/6J ±  kb
transcript OTTMUST00000043228 VEGA | MGI Sequence Detail 4146 Not Applicable  
polypeptide OTTMUSP00000019439 VEGA | MGI Sequence Detail 355 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    85 from dbSNP Build 137
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000013244 serine/threonine-protein kinase PRKX
  • EC
  • InterPro Domains
    IPR000961 AGC-kinase, C-terminal
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain
    IPR008271 Serine/threonine-protein kinase, active site
    IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
Molecular
Reagents
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  • All nucleic 68
    Genomic 1
    cDNA 67

    Microarray probesets 4
References
more
  • Summaries
    All 25
    Developmental Gene Expression 2
    Gene Ontology 5
    Phenotypes 3
  • Earliest
    J:45217 Blaschke RJ, et al., Man to mouse--lessons learned from the distal end of the human X chromosome. Genome Res. 1997 Dec;7(12):1114-7
  • Latest
    J:177220 Li X, et al., PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation. Dev Biol. 2011 Aug 15;356(2):475-85

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
01/26/2016
MGI 6.02
The Jackson Laboratory