Prkx
Gene Detail

Symbol Name ID

Prkx protein kinase, X-linked MGI:1309999

Synonyms

Pkare

Feature Type

protein coding gene

Genetic Map

Chromosome X

38.32 cM
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

ChrX:77761411-77796278 bp, - strand From VEGA annotation of GRCm38   34868 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:55868  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: kinase-related transforming protein
Gene Tree: Prkx

Human homologs

Human Homolog		PRKX, protein kinase, X-linked
NCBI Gene ID		5613
neXtProt AC		NX_P51817
Human Synonyms		PKX1
Human Chr (Location)		Xp22.3; chrX:3522384-3631675 (-)  GRCh37.p10

Alleles and phenotypes

All alleles(1) : Targeted(1)

Gene Ontology (GO) classifications

All GO classifications: (34 annotations)

Process	angiogenesis, cell adhesion, ...
Component	cytoplasm, nucleus
Function	ATP binding, cAMP-dependent protein kinase activity, ...

External Resources: FuncBase

Expression

Literature Summary: (2 records)
Data Summary: Results (32)    Tissues (28)   
Theiler Stages: 15, 20, 22, 24, 26

Assay Type	Results
Immunohistochemistry	32

cDNA source data(68)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(71) Genomic(1) cDNA(70)
Microarray probesets(4)

Other database links

VEGA Gene Model	OTTMUSG00000017860 (Evidence)
Ensembl Gene Model	ENSMUSG00000035725 (Evidence)
Entrez Gene	19108 (Evidence)
UniGene	290338
DFCI	TC1574487, TC1780077
DoTS	DT.97379079
NIA Mouse Gene Index	U039494
EC	2.7.11.1
Consensus CDS Project	CCDS30248.1
International Mouse Knockout Project Status	Prkx

Sequences

Length	Strain/Species
genomic	OTTMUSG00000017860	VEGA Gene Model | MGI Sequence Detail	34868	C57BL/6J
transcript	OTTMUST00000043228	VEGA | MGI Sequence Detail	4146	Not Applicable
polypeptide	OTTMUSP00000019439	VEGA | MGI Sequence Detail	355	Not Applicable

All sequences(36) RefSeq(2) UniProt(3)

Polymorphisms

SNPs(81 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR000961	AGC-kinase, C-terminal
InterPro	IPR017441	Protein kinase, ATP binding site
InterPro	IPR000719	Protein kinase, catalytic domain
InterPro	IPR011009	Protein kinase-like domain
InterPro	IPR002290	Serine/threonine- / dual specificity protein kinase, catalytic domain
InterPro	IPR008271	Serine/threonine-protein kinase, active site
InterPro	IPR001245	Serine-threonine/tyrosine-protein kinase catalytic domain
Protein Ontology	PR:000013244	serine/threonine-protein kinase PRKX

References

(Earliest) J:45217 Blaschke RJ, et al., Man to mouse--lessons learned from the distal end of the human X chromosome. Genome Res. 1997 Dec;7(12):1114-7
(Latest) J:177220 Li X, et al., PRKX critically regulates endothelial cell proliferation, migration, and vascular-like structure formation. Dev Biol. 2011 Aug 15;356(2):475-85
All references(28)