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Marco Gene Detail
Summary
  • Symbol
    Marco
  • Name
    macrophage receptor with collagenous structure
  • Synonyms
    Scara2
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309998
    NCBI Gene: 17167
  • Gene Overview
    MyGene.info: MARCO
  • Alliance
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:120474538-120505024 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 52.71 cM, cytoband E4-F
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    116 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309998
protein coding gene Chr1:120474538-120505084 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016407
protein coding gene Chr1:123286956-123317302 (-)
A/J MGP_AJ_G0016390
protein coding gene Chr1:118860745-118891153 (-)
AKR/J MGP_AKRJ_G0016355
protein coding gene Chr1:122364206-122396052 (-)
BALB/cJ MGP_BALBcJ_G0016350
protein coding gene Chr1:119125567-119156733 (-)
C3H/HeJ MGP_C3HHeJ_G0016176
protein coding gene Chr1:122528237-122560753 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016811
protein coding gene Chr1:127954081-127984413 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014524
protein coding gene Chr1:112499052-112529418 (-)
CAST/EiJ MGP_CASTEiJ_G0015757
protein coding gene Chr1:121330178-121360517 (-)
CBA/J MGP_CBAJ_G0016149
protein coding gene Chr1:132418909-132449303 (-)
DBA/2J MGP_DBA2J_G0016255
protein coding gene Chr1:117882199-117912577 (-)
FVB/NJ MGP_FVBNJ_G0016254
protein coding gene Chr1:116641112-116671492 (-)
LP/J MGP_LPJ_G0016326
protein coding gene Chr1:124634608-124667731 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016279
protein coding gene Chr1:138136690-138168789 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016847
protein coding gene Chr1:122072429-122102773 (-)
PWK/PhJ MGP_PWKPhJ_G0015543
protein coding gene Chr1:116871134-116901844 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015331
protein coding gene Chr1:120982469-121014167 (-)
WSB/EiJ MGP_WSBEiJ_G0015819
protein coding gene Chr1:121962307-121993877 (-)



Homology
more
  • Human Ortholog
    MARCO, macrophage receptor with collagenous structure
  • Vertebrate Orthologs
    9
  • Human Ortholog
    MARCO, macrophage receptor with collagenous structure
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SCARA2, SR-A6
  • Links
    NCBI Gene ID: 8685
    neXtProt AC: NX_Q9UEW3
    UniProt: Q9UEW3

  • Chr Location
    2q14.2; chr2:118942166-118994664 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 4928
    1 human;1 mouse;1 rat;1 chimpanzee;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: MARCO
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 2 alleles in 2 genetic backgrounds
    4 phenotypes from multigenic genotypes
    36 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele show altered spleen marginal zone architecture and impaired IgM responses to a pneumococcal polysaccharide vaccine. Mice homozygous for another null allele show increased susceptibility to bacterial pneumonia and enhanced inflammatory responses to inhaled particles.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000026390 Ensembl Gene Model | MGI Sequence Detail 30487 C57BL/6J ±  kb
    transcript ENSMUST00000027639 Ensembl | MGI Sequence Detail 1925 Not Applicable  
    polypeptide ENSMUSP00000027639 Ensembl | MGI Sequence Detail 518 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 3
      cDNA 11
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGI:2138205
    References
    more
    • Summaries
      All 79
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 36
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:251631 Shichita T, et al., MAFB prevents excess inflammation after ischemic stroke by accelerating clearance of damage signals through MSR1. Nat Med. 2017 Jun;23(6):723-732

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
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    last database update
    11/13/2018
    MGI 6.13
    The Jackson Laboratory