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Marco
Gene Detail
Symbol

Name
ID
Marco
macrophage receptor with collagenous structure
MGI:1309998
Synonyms
Scara2
Feature Type
protein coding gene
Genetic Map
Chromosome 1
52.71 cM, cytoband E4-F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:120474538-120505024 bp, - strand
From VEGA annotation of GRCm38

  30487 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4928  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: MARCO
Gene Tree: Marco

Human
homologs
MARCO, macrophage receptor with collagenous structure
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 8685
neXtProt AC: NX_Q9UEW3

Human Synonyms: SCARA2

Human Chr (Location): 2q14.2; chr2:118942166-118994664 (+)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
Mice homozygous for a null allele show altered spleen marginal zone architecture and impaired IgM responses to a pneumococcal polysaccharide vaccine. Mice homozygous for another null allele show increased susceptibility to bacterial pneumonia and enhanced inflammatory responses to inhaled particles.
 
Interactions
Marco interacts with 21 markers (Mir208a, Mir208b, Mir299b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process apoptotic cell clearance, endocytosis, ...
Component collagen trimer, integral component of membrane, ...
Function scavenger receptor activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(11)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: ZFIN marco    NEW 
Molecular
reagents
All nucleic(14) Genomic(2) cDNA(11) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene Model OTTMUSG00000049075 (Evidence)
Ensembl Gene Model ENSMUSG00000026390 (Evidence)
Entrez Gene 17167 (Evidence)
UniGene 1856
DFCI TC1585517, TC1736086
DoTS DT.40137427, DT.94139506
NIA Mouse Gene Index U021705
PDB 2OY3, 2OYA
Consensus CDS Project CCDS15234.1
International Mouse Phenotyping Consortium Status Marco
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049075 VEGA Gene Model | MGI Sequence Detail 30487 C57BL/6J ±  kb
transcript OTTMUST00000125330 VEGA | MGI Sequence Detail 1925 Not Applicable 
polypeptide OTTMUSP00000067982 VEGA | MGI Sequence Detail 518 Not Applicable 

For the selected sequences
All sequences(44) RefSeq(2) UniProt(6)
Polymorphisms
SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR001190 SRCR domain
InterPro IPR017448 SRCR-like domain
Protein Ontology PR:000001884 macrophage receptor MARCO
References
(Earliest) J:23295 Elomaa O, et al., Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages. Cell. 1995 Feb 24;80(4):603-9
(Latest) J:213531 Getts DR, et al., Therapeutic inflammatory monocyte modulation using immune-modifying microparticles. Sci Transl Med. 2014 Jan 15;6(219):219ra7
All references(62)
Other
accession IDs
MGI:2138205

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory