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Marco
Gene Detail
 Symbol
Name
ID
Marco
macrophage receptor with collagenous structure
MGI:1309998
Synonyms Scara2
Feature Type protein coding gene
Genetic Map
Chromosome 1
52.71 cM, cytoband E4-F
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr1:120474538-120505024 bp, - strand
From VEGA annotation of GRCm38

  30487 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4928  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Marco

Human
homologs
Human Homolog MARCO, macrophage receptor with collagenous structure
NCBI Gene ID 8685
neXtProt AC  NX_Q9UEW3
Human Synonyms  SCARA2
Human Chr (Location)  2q14.2; chr2:118942169-118994660 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele show altered spleen marginal zone architecture and impaired IgM responses to a pneumococcal polysaccharide vaccine. Mice homozygous for another null allele show increased susceptibility to bacterial pneumonia and enhanced inflammatory responses to inhaled particles.
 
Interactions
Marco interacts with 21 markers (Mir208a, Mir208b, Mir299b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process apoptotic cell clearance, endocytosis, ...
Component collagen trimer, integral component of membrane, ...
Function scavenger receptor activity
External Resources: FuncBase
Expression
Literature Summary: (3 records)
cDNA source data(11)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) Genomic(2) cDNA(11) Other(1)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000049075 (Evidence)
Ensembl Gene ModelENSMUSG00000026390 (Evidence)
Entrez Gene17167 (Evidence)
UniGene1856
DFCITC1585517, TC1736086
DoTSDT.40137427, DT.94139506
NIA Mouse Gene IndexU021705
PDB2OYA, 2OY3
Consensus CDS ProjectCCDS15234.1
International Mouse Knockout Project StatusMarco
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000049075 VEGA Gene Model | MGI Sequence Detail 30487 C57BL/6J ±  kb
transcript OTTMUST00000125330 VEGA | MGI Sequence Detail 1925 Not Applicable 
polypeptide OTTMUSP00000067982 VEGA | MGI Sequence Detail 518 Not Applicable 

For the selected sequences
All sequences(41) RefSeq(2) UniProt(5)
Polymorphisms SNPs within 2kb(116 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR008160 Collagen triple helix repeat
InterPro IPR001190 Speract/scavenger receptor
InterPro IPR017448 Speract/scavenger receptor-related
Protein Ontology PR:000001884 macrophage receptor MARCO
References (Earliest) J:23295 Elomaa O, et al., Cloning of a novel bacteria-binding receptor structurally related to scavenger receptors and expressed in a subset of macrophages. Cell. 1995 Feb 24;80(4):603-9
(Latest) J:204858 Jing J, et al., Role of macrophage receptor with collagenous structure in innate immune tolerance. J Immunol. 2013 Jun 15;190(12):6360-7
All references(60)
Other
accession IDs
MGI:2138205

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/26/2014
MGI 5.19
The Jackson Laboratory