Gsta4
Gene Detail

Symbol Name ID

Gsta4 glutathione S-transferase, alpha 4 MGI:1309515

Synonyms

GST 5.7, mGsta4

Feature Type

protein coding gene

Genetic Map

Chromosome 9

43.65 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(4)

Sequence Map

Chr9:78191966-78209348 bp, + strand From Ensembl annotation of GRCm38   17383 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Mammalian homology

human; rat; dog, domestic    (Mammalian Orthology)
Comparative Map (Mouse/Human Gsta4 ± 2 cM)

Gene Tree: Gsta4

Human ortholog

GSTA4 glutathione S-transferase alpha 4 NCBI Gene ID 2941
Human Synonyms: GSTA4-4, GTA4
Human Chr6:52842746-52860178 bp, - strand Reference GRCh37.p2 Primary Assembly

Alleles and phenotypes

All alleles(162) : Targeted(3) Gene trapped(159)
 

Mice homozygous for disruptions in this gene display increased sensitivity to oxidative stress, increased alanine and aspartate transaminase levels, increased susceptibility to bacterial infection, reduced litter size, and impaired glucose tolerance.

 

Gene Ontology (GO) classifications

All GO classifications: (13 annotations)

Process	glutathione metabolic process, metabolic process, ...
Component	cytoplasm, mitochondrion
Function	drug binding, glutathione binding, ...

External Resources: FuncBase

Expression

Literature Summary: (9 records)
Data Summary: Results (788)    Tissues (150)    Images (102)
Theiler Stages: 5, 11, 13, 21, 22, 23

Assay Type	Results
RNA in situ	788

cDNA source data(110)
External Resources: Allen Institute   GEO   ArrayExpress

Molecular reagents

All nucleic(112) cDNA(110) Primer pair(1) Other(1)
Microarray probesets(3)

Other database links

Ensembl Gene Model	ENSMUSG00000032348 (Evidence)
Entrez Gene	14860 (Evidence)
UniGene	2662
DFCI	TC1574931, TC1671417
DoTS	DT.535971, DT.97414514
NIA Mouse Gene Index	U010777
EC	2.5.1.18
PDB	1B48, 1GUK
Consensus CDS Project	CCDS23357.1
International Mouse Knockout Project Status	Gsta4

Sequences

Length	Strain/Species
genomic	ENSMUSG00000032348	Ensembl Gene Model | MGI Sequence Detail	17383	C57BL/6J
transcript	ENSMUST00000034903	Ensembl | MGI Sequence Detail	957	Not Applicable
polypeptide	ENSMUSP00000034903	Ensembl | MGI Sequence Detail	222	Not Applicable

All sequences(28) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(224 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR003080	Glutathione S-transferase, alpha class
InterPro	IPR017933	Glutathione S-transferase/chloride channel, C-terminal
InterPro	IPR004046	Glutathione S-transferase, C-terminal
InterPro	IPR010987	Glutathione S-transferase, C-terminal-like
InterPro	IPR004045	Glutathione S-transferase, N-terminal
InterPro	IPR012336	Thioredoxin-like fold
Protein Ontology	PR:000008297	glutathione S-transferase A4

References

(Earliest) J:3306 Zimniak P, et al., A subgroup of class alpha glutathione S-transferases. Cloning of cDNA for mouse lung glutathione S-transferase GST 5.7. FEBS Lett. 1992 Nov 23;313(2):173-6
(Latest) J:189537 Liang A, et al., Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis. J Pathol. 2012 Jun 19;
All references(51)