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Gsta4 Gene Detail
Summary
  • Symbol
    Gsta4
  • Name
    glutathione S-transferase, alpha 4
  • Synonyms
    GST 5.7, mGsta4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309515
    NCBI Gene: 14860
  • Member of
    Gsta cluster
Location & Maps
more
  • Sequence Map
    Chr9:78191966-78209348 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      17383 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 43.65 cM, cytoband E1
  • Mapping Data
    4 experiments
Homology
less
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    12 phenotypes from 3 alleles in 3 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    165
  • Chemically induced (other)
    1
  • Gene trapped
    159
  • Radiation induced
    1
  • Targeted
    4
  • Genomic Mutations
    2 involving Gsta4
  • Incidental Mutations
    APF , CvDC
Mice homozygous for disruptions in this gene display increased sensitivity to oxidative stress, increased alanine and aspartate transaminase levels, increased susceptibility to bacterial infection, reduced litter size, and impaired glucose tolerance.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032348 Ensembl Gene Model | MGI Sequence Detail 17383 C57BL/6J ±  kb
transcript ENSMUST00000034903 Ensembl | MGI Sequence Detail 957 Not Applicable  
polypeptide ENSMUSP00000034903 Ensembl | MGI Sequence Detail 222 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    275 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 112
    cDNA 110
    Primer pair 1
    Other 1

    Microarray probesets 3
References
more
  • Summaries
    All 51
    Developmental Gene Expression 10
    Gene Ontology 5
    Phenotypes 23
  • Earliest
    J:3306 Zimniak P, et al., A subgroup of class alpha glutathione S-transferases. Cloning of cDNA for mouse lung glutathione S-transferase GST 5.7. FEBS Lett. 1992 Nov 23;313(2):173-6
  • Latest
    J:223850 Ronis MJ, et al., Increased 4-hydroxynonenal protein adducts in male GSTA4-4/PPAR-alpha double knockout mice enhance injury during early stages of alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol. 2015 Mar 1;308(5):G403-15

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory