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Gsta4
Gene Detail
 Symbol
Name
ID
Member of
Gsta4
glutathione S-transferase, alpha 4
MGI:1309515
Gsta cluster
Synonyms GST 5.7, mGsta4
Feature Type protein coding gene
Genetic Map
Chromosome 9
43.65 cM, cytoband E1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr9:78191966-78209348 bp, + strand
From Ensembl annotation of GRCm38

  17383 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:135605  Vertebrate Homology Class
1 mouse; 2 rat; 1 cattle; 1 dog; 1 zebrafish

Gene Tree: Gsta4

Mutations,
alleles, and
phenotypes
All mutations/alleles(163) : Gene trapped(159) Radiation induced(1) Targeted(3)
Genomic Mutations involving Gsta4 (1)
Incidental mutations (data from APF )
 
Mice homozygous for disruptions in this gene display increased sensitivity to oxidative stress, increased alanine and aspartate transaminase levels, increased susceptibility to bacterial infection, reduced litter size, and impaired glucose tolerance.
 
Interactions
Gsta4 interacts with 31 markers (Mir1a-1, Mir1a-2, Mir27b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (9 annotations)
Process metabolic process
Component cytoplasm, mitochondrion
Function drug binding, glutathione binding, ...
External Resources: FuncBase
Expression
Literature Summary: (10 records)
Data Summary: Results (834)    Tissues (196)    Images (104)
Theiler Stages: 5, 11, 13, 21, 22, 23, 26, 28
Assay TypeResults
RNA in situ 834
cDNA source data(110)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(112) cDNA(110) Primer pair(1) Other(1)
Microarray probesets(3)
Other database
links
Ensembl Gene ModelENSMUSG00000032348 (Evidence)
Entrez Gene14860 (Evidence)
UniGene2662
DFCITC1574931, TC1671417
DoTSDT.535971, DT.97414514
NIA Mouse Gene IndexU010777
EC2.5.1.18
PDB1GUK, 1B48
Consensus CDS ProjectCCDS23357.1
International Mouse Knockout Project StatusGsta4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000032348 Ensembl Gene Model | MGI Sequence Detail 17383 C57BL/6J ±  kb
transcript ENSMUST00000034903 Ensembl | MGI Sequence Detail 957 Not Applicable 
polypeptide ENSMUSP00000034903 Ensembl | MGI Sequence Detail 222 Not Applicable 

For the selected sequences
All sequences(28) RefSeq(2) UniProt(1)
Polymorphisms SNPs within 2kb(307 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003080 Glutathione S-transferase, alpha class
InterPro IPR004046 Glutathione S-transferase, C-terminal
InterPro IPR010987 Glutathione S-transferase, C-terminal-like
InterPro IPR004045 Glutathione S-transferase, N-terminal
InterPro IPR012336 Thioredoxin-like fold
Protein Ontology PR:000008297 glutathione S-transferase A4
References (Earliest) J:3306 Zimniak P, et al., A subgroup of class alpha glutathione S-transferases. Cloning of cDNA for mouse lung glutathione S-transferase GST 5.7. FEBS Lett. 1992 Nov 23;313(2):173-6
(Latest) J:189537 Liang A, et al., Loss of glutathione S-transferase A4 accelerates obstruction-induced tubule damage and renal fibrosis. J Pathol. 2012 Jun 19;
All references(52)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/12/2014
MGI 5.19
The Jackson Laboratory