About   Help   FAQ
Cdc7 Gene Detail
Summary
  • Symbol
    Cdc7
  • Name
    cell division cycle 7 (S. cerevisiae)
  • Synonyms
    Cdc7, Cdc7l1, muCdc7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309511
    NCBI Gene: 12545
  • Alliance
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:106964322-106984432 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 51.43 cM, cytoband E
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    90 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309511
protein coding gene Chr5:106964315-106984440 (.)
129S1/SvImJ MGP_129S1SvImJ_G0029833
protein coding gene Chr5:108949949-108970002 (+)
A/J MGP_AJ_G0029797
protein coding gene Chr5:104787044-104807339 (+)
AKR/J MGP_AKRJ_G0029742
protein coding gene Chr5:108186084-108206301 (+)
BALB/cJ MGP_BALBcJ_G0029809
protein coding gene Chr5:105928866-105950678 (+)
C3H/HeJ MGP_C3HHeJ_G0029531
protein coding gene Chr5:108630594-108651886 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030263
protein coding gene Chr5:113458212-113479765 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027497
protein coding gene Chr5:99861619-99881606 (+)
CAST/EiJ MGP_CASTEiJ_G0028945
protein coding gene Chr5:107543133-107564058 (+)
CBA/J MGP_CBAJ_G0029499
protein coding gene Chr5:117242828-117262929 (+)
DBA/2J MGP_DBA2J_G0029645
protein coding gene Chr5:104925916-104945944 (+)
FVB/NJ MGP_FVBNJ_G0029602
protein coding gene Chr5:103661213-103681293 (+)
LP/J MGP_LPJ_G0029733
protein coding gene Chr5:109545077-109565771 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0029634
protein coding gene Chr5:122200145-122221770 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030297
protein coding gene Chr5:107733453-107754123 (+)
PWK/PhJ MGP_PWKPhJ_G0028658
protein coding gene Chr5:103718415-103738957 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028496
protein coding gene Chr5:105229131-105252225 (+)
WSB/EiJ MGP_WSBEiJ_G0029018
protein coding gene Chr5:108029124-108050118 (+)



Homology
more
  • Human Ortholog
    CDC7, cell division cycle 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDC7, cell division cycle 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDC7L1, HsCDC7, Hsk1, huCDC7
  • Links
    NCBI Gene ID: 8317
    neXtProt AC: NX_O00311
    UniProt: O00311

  • Chr Location
    1p22.1; chr1:91500814-91525764 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31166
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CDC7
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 3 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality between E3.5-E6.5. In conjunction with a Trp53-null allele, double homozygous mutant embryos survive up to E8.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000029283 Ensembl Gene Model | MGI Sequence Detail 20111 C57BL/6J ±  kb
    transcript ENSMUST00000031221 Ensembl | MGI Sequence Detail 2961 Not Applicable  
    polypeptide ENSMUSP00000031221 Ensembl | MGI Sequence Detail 564 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 3
      cDNA 53

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140941
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 2
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:241732 O'Driscoll M, The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery. J Pathol. 2017 Jan;241(2):192-207

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
    Citing These Resources
    Funding Information
    Warranty Disclaimer & Copyright Notice
    Send questions and comments to User Support.
    last database update
    12/04/2018
    MGI 6.13
    The Jackson Laboratory