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Cdc7 Gene Detail
Summary
  • Symbol
    Cdc7
  • Name
    cell division cycle 7 (S. cerevisiae)
  • Synonyms
    Cdc7, Cdc7l1, muCdc7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309511
    NCBI Gene: 12545
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr5:106964322-106984432 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20111 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 51.43 cM, cytoband E
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CDC7, cell division cycle 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDC7, cell division cycle 7
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CDC7L1, HsCDC7, Hsk1, huCDC7
  • Links
    NCBI Gene ID: 8317
    neXtProt AC: NX_O00311
    UniProt: O00311

  • Chr Location
    1p22.1; chr1:91500814-91525764 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 31166
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: CDC7
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in embryonic lethality between E3.5-E6.5. In conjunction with a Trp53-null allele, double homozygous mutant embryos survive up to E8.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000028130 VEGA Gene Model | MGI Sequence Detail 20111 C57BL/6J ±  kb
    transcript OTTMUST00000069671 VEGA | MGI Sequence Detail 2961 Not Applicable  
    polypeptide OTTMUSP00000035415 VEGA | MGI Sequence Detail 564 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      90 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 56
      Genomic 3
      cDNA 53

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:2140941
    References
    more
    • Summaries
      All 49
      Developmental Gene Expression 2
      Gene Ontology 4
      Phenotypes 19
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:241732 O'Driscoll M, The pathological consequences of impaired genome integrity in humans; disorders of the DNA replication machinery. J Pathol. 2017 Jan;241(2):192-207

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    07/10/2018
    MGI 6.12
    The Jackson Laboratory