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Cdc7 Gene Detail
Summary
  • Symbol
    Cdc7
  • Name
    cell division cycle 7 (S. cerevisiae)
  • Synonyms
    Cdc7, Cdc7l1, muCdc7
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309511
    NCBI Gene: 12545
Location & Maps
more
  • Sequence Map
    Chr5:106964322-106984432 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      20111 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 5, 51.43 cM, cytoband E
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    CDC7, cell division cycle 7
  • Vertebrate Orthologs
    10
  • Human Ortholog
    CDC7, cell division cycle 7
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CDC7L1, HsCDC7, Hsk1, huCDC7
  • Links
    NCBI Gene ID: 8317
    neXtProt AC: NX_O00311

  • Chr Location
    1p22; chr1:91500814-91525764 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 31166
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: CDC7
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    19 phenotypes from 3 alleles in 2 genetic backgrounds
    2 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    17
  • Chemically induced (other)
    1
  • Gene trapped
    6
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    7
  • Transgenic
    1
  • Genomic Mutations
    3 involving Cdc7
  • Incidental Mutations
Homozygous mutation of this gene results in embryonic lethality between E3.5-E6.5. In conjunction with a Trp53-null allele, double homozygous mutant embryos survive up to E8.5.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000028130 VEGA Gene Model | MGI Sequence Detail 20111 C57BL/6J ±  kb
transcript OTTMUST00000069671 VEGA | MGI Sequence Detail 2961 Not Applicable  
polypeptide OTTMUSP00000035415 VEGA | MGI Sequence Detail 564 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    90 from dbSNP Build 142
Protein
Information
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  • UniProt
    7 Sequences
  • Protein Ontology
    PR:000005218 cell division cycle 7-related protein kinase
  • EC
  • InterPro Domains
    IPR017441 Protein kinase, ATP binding site
    IPR000719 Protein kinase domain
    IPR011009 Protein kinase-like domain
    IPR008271 Serine/threonine-protein kinase, active site
Molecular
Reagents
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  • All nucleic 55
    Genomic 3
    cDNA 52

    Microarray probesets 5
Other
Accession IDs
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MGI:2140941
References
more
  • Summaries
    All 39
    Developmental Gene Expression 2
    Gene Ontology 4
    Phenotypes 18
  • Earliest
    J:49579 Kim JM, et al., Growth regulation of the expression of mouse cDNA and gene encoding a serine/threonine kinase related to Saccharomyces cerevisiae CDC7 essential for G1/S transition. Structure, chromosomal localization, and expression of mouse gene for s. cerevisiae Cdc7-related kinase. (Correction: 1998;273(42):27755). J Biol Chem. 1998 Sep 4;273(36):23248-57
  • Latest
    J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/22/2016
MGI 6.04
The Jackson Laboratory