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Trip12 Gene Detail
Summary
  • Symbol
    Trip12
  • Name
    thyroid hormone receptor interactor 12
  • Synonyms
    1110036I07Rik, 6720416K24Rik, Gtl6
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309481
    NCBI Gene: 14897
  • Gene Overview
    MyGene.info: TRIP12
  • Alliance
  • Transcription Start Sites
    21 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:84721189-84840516 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 1, 43.42 cM, cytoband F
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    475 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309481
protein coding gene Chr1:84721189-84850008 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016228
protein coding gene Chr1:85757917-85886098 (-)
A/J MGP_AJ_G0016211
protein coding gene Chr1:82676044-82795335 (-)
AKR/J MGP_AKRJ_G0016168
protein coding gene Chr1:84937640-85059093 (-)
BALB/cJ MGP_BALBcJ_G0016166
protein coding gene Chr1:82811646-82937104 (-)
C3H/HeJ MGP_C3HHeJ_G0015996
protein coding gene Chr1:85318219-85447834 (-)
C57BL/6NJ MGP_C57BL6NJ_G0016619
protein coding gene Chr1:89028460-89179524 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014339
protein coding gene Chr1:77772772-77889705 (-)
CAST/EiJ MGP_CASTEiJ_G0015581
protein coding gene Chr1:84730557-84859564 (-)
CBA/J MGP_CBAJ_G0015970
protein coding gene Chr1:91892238-92019067 (-)
DBA/2J MGP_DBA2J_G0016071
protein coding gene Chr1:81969436-82091914 (-)
FVB/NJ MGP_FVBNJ_G0016074
protein coding gene Chr1:81051188-81173682 (-)
LP/J MGP_LPJ_G0016144
protein coding gene Chr1:86808431-86937713 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016094
protein coding gene Chr1:95253201-95398969 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0016666
protein coding gene Chr1:85114665-85245093 (-)
PWK/PhJ MGP_PWKPhJ_G0015367
protein coding gene Chr1:81370436-81497247 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015145
protein coding gene Chr1:84296474-84426599 (-)
WSB/EiJ MGP_WSBEiJ_G0015642
protein coding gene Chr1:84882624-85009104 (-)



Homology
more
  • Human Ortholog
    TRIP12, thyroid hormone receptor interactor 12
  • Vertebrate Orthologs
    10
  • Human Ortholog
    TRIP12, thyroid hormone receptor interactor 12
    Orthology source: HomoloGene, HGNC
  • Synonyms
    MRD49, TRIP-12, ULF
  • Links
    NCBI Gene ID: 9320
    neXtProt AC: NX_Q14669
    UniProt: Q14669

  • Chr Location
    2q36.3; chr2:229763837-229923234 (-)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 44226
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: TRIP12
  • Gene Tree
Human Diseases
more
  • Diseases
    1 with human TRIP12 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    6 phenotypes from 2 alleles in 1 genetic background
    2 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a targeted allele exhibit complete embryonic lethality during organogenesis associated with embryonic growth retardation and abnormal placenta development.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000026219 Ensembl Gene Model | MGI Sequence Detail 119328 C57BL/6J ±  kb
transcript ENSMUST00000027421 Ensembl | MGI Sequence Detail 9632 Not Applicable  
polypeptide ENSMUSP00000027421 Ensembl | MGI Sequence Detail 2025 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 31
    cDNA 31

    Microarray probesets 9
Other
Accession IDs
less
MGI:1921001, MGI:2142937, MGI:2444080
References
more
  • Summaries
    All 46
    Developmental Gene Expression 3
    Gene Ontology 6
    Phenotypes 16
  • Earliest
    J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
  • Latest
    J:199251 Chen D, et al., Differential Effects on ARF Stability by Normal versus Oncogenic Levels of c-Myc Expression. Mol Cell. 2013 Jul 11;51(1):46-56

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory