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Ltb4r1 Gene Detail
Summary
  • Symbol
    Ltb4r1
  • Name
    leukotriene B4 receptor 1
  • Synonyms
    BLT1, BLTR, mBLTR
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309472
    NCBI Gene: 16995
  • Gene Overview
    MyGene.info: LTB4R
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr14:55765962-55768494 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2533 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 14, 28.19 cM
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    LTB4R, leukotriene B4 receptor
  • Vertebrate Orthologs
    9
  • Human Ortholog
    LTB4R, leukotriene B4 receptor
    Orthology source: HomoloGene, HGNC
  • Synonyms
    BLT1, BLTR, CMKRL1, GPR16, LTB4R1, LTBR1, P2RY7, P2Y7
  • Links
    NCBI Gene ID: 1241
    neXtProt AC: NX_Q15722
    UniProt: Q15722

  • Chr Location
    14q12; chr14:24311499-24318036 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    20 phenotypes from 3 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    62 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Nullizygous mutations cause impaired Ltb4-driven chemotaxis and adhesion. Homozygous null phenotypes include attenuated autoAb-driven arthritis, adoptive transfer-induced uveitis, airway hyperresponsiveness and Th2-type immune responses, and reduced eosinophil recruitment in induced peritonitis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000034668 VEGA Gene Model | MGI Sequence Detail 2533 C57BL/6J ±  kb
    transcript OTTMUST00000087999 VEGA | MGI Sequence Detail 1394 Not Applicable  
    polypeptide OTTMUSP00000047935 VEGA | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      14 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 4
      cDNA 15

      Microarray probesets 4
    References
    more
    • Summaries
      All 107
      Developmental Gene Expression 1
      Gene Ontology 5
      Phenotypes 62
    • Earliest
      J:50101 Huang WW, et al., Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils. J Exp Med. 1998 Sep 21;188(6):1063-74
    • Latest
      J:260077 Miyabe Y, et al., Complement C5a Receptor is the Key Initiator of Neutrophil Adhesion Igniting Immune Complex-induced Arthritis. Sci Immunol. 2017 Jan;2(7)

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory