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Slc12a4
Gene Detail
Symbol

Name
ID
Slc12a4
solute carrier family 12, member 4
MGI:1309465
Synonyms
KCC1, K-Cl Co-transporter-1
Feature Type
protein coding gene
Genetic Map
Chromosome 8
53.06 cM
Detailed Genetic Map ± 1 cM


Mapping data(3)
Sequence Map
Chr8:105943590-105966074 bp, - strand
From VEGA annotation of GRCm38

  22485 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:21056  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SLC12A4
Gene Tree: Slc12a4

Human
homologs
SLC12A4, solute carrier family 12 (potassium/chloride transporter), member 4
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 6560
neXtProt AC: NX_Q9UP95

Human Synonyms: KCC1

Human Chr (Location): 16q22.1; chr16:67943474-67968694 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(14) : Gene trapped(11) Targeted(3)
Incidental mutations (data from Mutagenetix , APF )
Interactions
Slc12a4 interacts with 114 markers (Mir15a, Mir15b, Mir16-1, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (16 annotations)
Process ion transport, potassium ion transport, ...
Component integral component of membrane, lysosomal membrane, ...
Function cation:chloride symporter activity, potassium:chloride symporter activity, ...
External Resources: FuncBase
Expression
Literature Summary: (5 records)
Data Summary: Results (10)    Tissues (9)    Tissue x Stage Matrix (view)
Assay TypeResults
RT-PCR 10
cDNA source data(58)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase slc12a4 ; ZFIN slc12a4    NEW 
Molecular
reagents
All nucleic(65) Genomic(2) cDNA(58) Primer pair(5)
Microarray probesets(3)
Other database
links
VEGA Gene Model OTTMUSG00000031019 (Evidence)
Ensembl Gene Model ENSMUSG00000017765 (Evidence)
Entrez Gene 20498 (Evidence)
UniGene 292447
DFCI TC1575113
DoTS DT.110893220, DT.110893239, DT.529855
NIA Mouse Gene Index U030191
Consensus CDS Project CCDS22623.1, CCDS57642.1
International Mouse Phenotyping Consortium Status Slc12a4
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000031019 VEGA Gene Model | MGI Sequence Detail 22485 C57BL/6J ±  kb
transcript OTTMUST00000076845 VEGA | MGI Sequence Detail 3755 Not Applicable 
polypeptide OTTMUSP00000040516 VEGA | MGI Sequence Detail 1085 Not Applicable 

For the selected sequences
All sequences(94) RefSeq(7) UniProt(13)
Polymorphisms
PCR(3) : SNPs within 2kb(204 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR004841 Amino acid permease domain
InterPro IPR000076 K-Cl co-transporter
InterPro IPR000622 K/Cl co-transporter, type 1
InterPro IPR018491 K/Cl co-transporter, type 1/type 3
InterPro IPR004842 Na/K/Cl co-transporter superfamily
Protein Ontology PR:000014927 solute carrier family 12 member 4
References
(Earliest) J:46469 Pellegrino CM, et al., Molecular identification and expression of erythroid K:Cl cotransporter in human and mouse erythroleukemic cells. Blood Cells Mol Dis. 1998 Mar;24(1):31-40
(Latest) J:193822 Lumayag S, et al., Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Proc Natl Acad Sci U S A. 2013 Feb 5;110(6):E507-16
All references(38)
Other
accession IDs
MGI:2142802

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/18/2015
MGI 6.0
The Jackson Laboratory