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Hspa13 Gene Detail
Summary
  • Symbol
    Hspa13
  • Name
    heat shock protein 70 family, member 13
  • Synonyms
    1600002I10Rik, 60kDa, B230217N24Rik, Stch
  • Feature Type
    protein coding gene
  • IDs
    MGI:1309463
    NCBI Gene: 110920
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr16:75552078-75564575 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
  • Genetic Map
    Chromosome 16, 43.36 cM, cytoband C3.2
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    127 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1309463
protein coding gene Chr16:75542319-75564575 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022954
protein coding gene Chr16:75772476-75784098 (-)
A/J MGP_AJ_G0022922
protein coding gene Chr16:72436247-72448078 (-)
AKR/J MGP_AKRJ_G0022892
protein coding gene Chr16:74660545-74672176 (-)
BALB/cJ MGP_BALBcJ_G0022924
protein coding gene Chr16:72832963-72844594 (-)
C3H/HeJ MGP_C3HHeJ_G0022686
protein coding gene Chr16:75098269-75109900 (-)
C57BL/6NJ MGP_C57BL6NJ_G0023372
protein coding gene Chr16:78219431-78231062 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0020875
protein coding gene Chr16:71000810-71012576 (-)
CAST/EiJ MGP_CASTEiJ_G0022209
protein coding gene Chr16:75500029-75511683 (-)
CBA/J MGP_CBAJ_G0022656
protein coding gene Chr16:81552971-81564602 (-)
DBA/2J MGP_DBA2J_G0022789
protein coding gene Chr16:72276681-72288322 (-)
FVB/NJ MGP_FVBNJ_G0022764
protein coding gene Chr16:71668623-71680254 (-)
LP/J MGP_LPJ_G0022859
protein coding gene Chr16:75569139-75580761 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0022782
protein coding gene Chr16:84649163-84661685 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0023389
protein coding gene Chr16:74980732-74992375 (-)
PWK/PhJ MGP_PWKPhJ_G0021951
protein coding gene Chr16:72533951-72546049 (-)
SPRET/EiJ MGP_SPRETEiJ_G0021781
protein coding gene Chr16:74615228-74627871 (-)
WSB/EiJ MGP_WSBEiJ_G0022256
protein coding gene Chr16:75159489-75171120 (-)



Homology
more
  • Human Ortholog
    HSPA13, heat shock protein family A (Hsp70) member 13
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSPA13, heat shock protein family A (Hsp70) member 13
  • Synonyms
    STCH
  • Links
    NCBI Gene ID: 6782
    neXtProt AC: NX_P48723
    UniProt: P48723

  • Chr Location
    21q11.2; chr21:14371115-14383484 (-)  GRCh38

Human Diseases
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  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a conditional allele in immune cells exhibit reduction in plasmablast, plasma cell, and antibodies induced LPS or sheep red blood cells, and reduced susceptibility to systemic lupus erythematosus.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 110920 NCBI Gene Model | MGI Sequence Detail 12498 C57BL/6J ±  kb
    transcript NR_027492 RefSeq | MGI Sequence Detail 4175 ZRU/MplStud  
    polypeptide Q8BM72 UniProt | EBI | MGI Sequence Detail 471 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 19
      Genomic 1
      cDNA 17
      Primer pair 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGI:1917025, MGI:1926096, MGI:2146589
    References
    more
    • Summaries
      All 50
      Developmental Gene Expression 3
      Diseases 1
      Gene Ontology 3
      Phenotypes 18
    • Earliest
      J:47556 Reeves RH, et al., Stch maps to mouse chromosome 16, extending the conserved synteny with human chromosome 21. Genomics. 1998 Apr 1;49(1):156-7
    • Latest
      J:335294 Redhead Y, et al., Craniofacial dysmorphology in Down syndrome is caused by increased dosage of Dyrk1a and at least three other genes. Development. 2023 Apr 15;150(8):dev201077

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    last database update
    03/12/2024
    MGI 6.23
    The Jackson Laboratory