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Sema7a Gene Detail
Summary
  • Symbol
    Sema7a
  • Name
    sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
  • Synonyms
    2900057C09Rik, CDw108, Semal, Semaphorin K1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306826
    NCBI Gene: 20361
  • Gene Overview
    MyGene.info: SEMA7A
Location & Maps
more
  • Sequence Map
    Chr9:57940135-57962865 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22731 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SEMA7A, semaphorin 7A (John Milton Hagen blood group)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEMA7A, semaphorin 7A (John Milton Hagen blood group)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL
  • Links
    NCBI Gene ID: 8482
    neXtProt AC: NX_O75326

  • Chr Location
    15q22.3-q23; chr15:74409289-74433958 (-)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
The development of the olfactory tract is impaired in homozygous null mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 20361 NCBI Gene Model | MGI Sequence Detail 22731 C57BL/6J ±  kb
transcript NM_011352 RefSeq | MGI Sequence Detail 3290 Not Specified  
polypeptide Q9QUR8 UniProt | EBI | MGI Sequence Detail 664 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    114 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 23
    cDNA 19
    Primer pair 2
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGI:1925657
References
more
  • Summaries
    All 58
    Developmental Gene Expression 20
    Gene Ontology 5
    Phenotypes 15
  • Earliest
    J:49587 Xu X, et al., Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. J Biol Chem. 1998 Aug 28;273(35):22428-34
  • Latest
    J:221786 Parkash J, et al., Semaphorin7A regulates neuroglial plasticity in the adult hypothalamic median eminence. Nat Commun. 2015;6:6385

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory