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Sema7a
Gene Detail
Symbol

Name
ID
Sema7a
sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
MGI:1306826
Synonyms
2900057C09Rik, CDw108, Semal, Semaphorin K1
Feature Type
protein coding gene
Genetic Map
Chromosome 9
31.63 cM, cytoband A3.3-B
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr9:57940135-57962865 bp, + strand
From NCBI annotation of GRCm38

  22731 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2678  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: SEMA7A
Protein SuperFamily: semaphorin
Gene Tree: Sema7a

Human
homologs
SEMA7A, semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
Orthology source: HomoloGene, HGNC

IDs:
NCBI Gene ID: 8482
neXtProt AC: NX_O75326

Human Synonyms: CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL

Human Chr (Location): 15q22.3-q23; chr15:74409289-74433958 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from Mutagenetix , APF , CvDC )
 
The development of the olfactory tract is impaired in homozygous null mice.
 
Interactions
Sema7a interacts with 258 markers (Mir7-1, Mir7-2, Mir7b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (25 annotations)
Process axon extension, cell differentiation, ...
Component anchored component of membrane, external side of plasma membrane, ...
Function integrin binding
External Resources: FuncBase
Expression
Literature Summary: (19 records)
Data Summary: Results (162)    Tissues (149)    Images (30)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 151
Northern blot 10
RT-PCR 1
cDNA source data(19)
Other mouse links: Allen Institute   GENSAT   GEO   Expression Atlas
Other vertebrate links: GEISHA SEMA7A    NEW 
Molecular
reagents
All nucleic(22) cDNA(19) Primer pair(2) Other(1)
Microarray probesets(5)
Other database
links
Ensembl Gene Model ENSMUSG00000038264 (Evidence)
Entrez Gene 20361 (Evidence)
UniGene 335187
DFCI TC1581216
DoTS DT.99653926
NIA Mouse Gene Index U010558
Consensus CDS Project CCDS23235.1
International Mouse Phenotyping Consortium Status Sema7a
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic 20361 NCBI Gene Model | MGI Sequence Detail 22731 C57BL/6J ±  kb
transcript NM_011352 RefSeq | MGI Sequence Detail 3290 Not Specified 
polypeptide Q9QUR8 UniProt | EBI | MGI Sequence Detail 664 Not Applicable 

For the selected sequences
All sequences(23) RefSeq(6) UniProt(1)
Polymorphisms
SNPs within 2kb(115 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR007110 Immunoglobulin-like domain
InterPro IPR013783 Immunoglobulin-like fold
InterPro IPR003599 Immunoglobulin subtype
InterPro IPR002165 Plexin
InterPro IPR016201 Plexin-like fold
InterPro IPR027231 Semaphorin
InterPro IPR001627 Semaphorin/CD100 antigen
InterPro IPR015943 WD40/YVTN repeat-like-containing domain
Protein Ontology PR:000002085 semaphorin-7A
Graphical View of Protein Domain Structure
References
(Earliest) J:49587 Xu X, et al., Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. J Biol Chem. 1998 Aug 28;273(35):22428-34
(Latest) J:217738 Ma B, et al., Role of Chitinase 3-like-1 and Semaphorin 7a in Pulmonary Melanoma Metastasis. Cancer Res. 2015 Feb 1;75(3):487-96
All references(58)
Other
accession IDs
MGI:1925657

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
06/30/2015
MGI 5.22
The Jackson Laboratory