Sema7a
Gene Detail

Symbol Name ID

Sema7a sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A MGI:1306826

Synonyms

2900057C09Rik, CDw108, Semal, Semaphorin K1

Feature Type

protein coding gene

Genetic Map

Chromosome 9

31.63 cM, cytoband A3.3-B
Detailed Genetic Map ± 1 cM


Mapping data(2)

Sequence Map

Chr9:57940135-57962865 bp, + strand From NCBI annotation of GRCm38   22731 bp   ±  kb flank VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer

Mouse Genome Browser

Vertebrate homology

HomoloGene:2678  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 zebrafish

Protein SuperFamily: semaphorin
Gene Tree: Sema7a

Human homologs

Human Homolog		SEMA7A, semaphorin 7A, GPI membrane anchor (John Milton Hagen blood group)
NCBI Gene ID		8482
neXtProt AC		NX_O75326
Human Synonyms		CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL
Human Chr (Location)		15q22.3-q23; chr15:74701630-74726299 (-)  GRCh37.p10
Disease Associations		(1) Diseases Associated with Human SEMA7A

Alleles and phenotypes

All alleles(6) : Targeted(6)
 

The development of the olfactory tract is impaired in homozygous null mice.

 

Gene Ontology (GO) classifications

All GO classifications: (19 annotations)

Process	cell differentiation, inflammatory response, ...
Component	anchored to membrane, external side of plasma membrane, ...
Function	integrin binding, receptor activity

External Resources: FuncBase

Expression

Literature Summary: (17 records)
Data Summary: Results (162)    Tissues (148)    Images (30)
Theiler Stages: 19, 20, 21, 22, 23, 24, 25, 26, 28

Assay Type	Results
RNA in situ	151
Northern blot	10
RT-PCR	1

cDNA source data(19)
External Resources: Allen Institute   GENSAT   GEO   ArrayExpress

Molecular reagents

All nucleic(22) cDNA(19) Primer pair(2) Other(1)
Microarray probesets(5)

Other database links

Ensembl Gene Model	ENSMUSG00000038264 (Evidence)
Entrez Gene	20361 (Evidence)
UniGene	335187
DFCI	TC1581216
DoTS	DT.99653926
NIA Mouse Gene Index	U010558
Consensus CDS Project	CCDS23235.1
International Mouse Knockout Project Status	Sema7a

Sequences

Length	Strain/Species
genomic	20361	NCBI Gene Model | MGI Sequence Detail	22731	C57BL/6J
transcript	NM_011352	RefSeq | MGI Sequence Detail	3290	Not Specified
polypeptide	Q9QUR8	UniProt | EBI | MGI Sequence Detail	664	Not Applicable

All sequences(19) RefSeq(2) UniProt(1)

Polymorphisms

SNPs(92 from dbSNP Build 128)

Protein-related information

Resource	ID	Description
InterPro	IPR007110	Immunoglobulin-like
InterPro	IPR013783	Immunoglobulin-like fold
InterPro	IPR003599	Immunoglobulin subtype
InterPro	IPR002165	Plexin
InterPro	IPR016201	Plexin-like fold
InterPro	IPR003659	Plexin/semaphorin/integrin
InterPro	IPR001627	Semaphorin/CD100 antigen
InterPro	IPR015943	WD40/YVTN repeat-like-containing domain
Protein Ontology	PR:000002085	semaphorin-7A

Graphical View of Protein Domain Structure

References

(Earliest) J:49587 Xu X, et al., Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. J Biol Chem. 1998 Aug 28;273(35):22428-34
(Latest) J:189946 Sultana H, et al., Semaphorin 7A contributes to West Nile virus pathogenesis through TGF-beta1/Smad6 signaling. J Immunol. 2012 Sep 15;189(6):3150-8
All references(54)

Other accession IDs

MGI:1925657