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Sema7a Gene Detail
Summary
  • Symbol
    Sema7a
  • Name
    sema domain, immunoglobulin domain (Ig), and GPI membrane anchor, (semaphorin) 7A
  • Synonyms
    2900057C09Rik, CDw108, Semal, Semaphorin K1
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306826
    NCBI Gene: 20361
  • Gene Overview
    MyGene.info: SEMA7A
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr9:57940135-57962865 bp, + strand
  • From NCBI annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      22731 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 9, 31.63 cM, cytoband A3.3-B
  • Mapping Data
    2 experiments
Homology
more
  • Human Ortholog
    SEMA7A, semaphorin 7A (John Milton Hagen blood group)
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SEMA7A, semaphorin 7A (John Milton Hagen blood group)
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD108, CDw108, H-SEMA-K1, H-Sema-L, JMH, SEMAK1, SEMAL
  • Links
    NCBI Gene ID: 8482
    neXtProt AC: NX_O75326
    UniProt: O75326

  • Chr Location
    15q24.1; chr15:74409284-74433959 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
The development of the olfactory tract is impaired in homozygous null mice.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
    less
    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20361 NCBI Gene Model | MGI Sequence Detail 22731 C57BL/6J ±  kb
    transcript NM_011352 RefSeq | MGI Sequence Detail 3290 Not Specified  
    polypeptide Q9QUR8 UniProt | EBI | MGI Sequence Detail 664 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      114 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      cDNA 19
      Primer pair 2
      Other 2

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGI:1925657
    References
    more
    • Summaries
      All 65
      Developmental Gene Expression 22
      Gene Ontology 5
      Phenotypes 17
    • Earliest
      J:49587 Xu X, et al., Human semaphorin K1 is glycosylphosphatidylinositol-linked and defines a new subfamily of viral-related semaphorins. J Biol Chem. 1998 Aug 28;273(35):22428-34
    • Latest
      J:254718 Chabrat A, et al., Transcriptional repression of Plxnc1 by Lmx1a and Lmx1b directs topographic dopaminergic circuit formation. Nat Commun. 2017 Oct 16;8(1):933

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    05/15/2018
    MGI 6.12
    The Jackson Laboratory