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Suclg2 Gene Detail
Summary
  • Symbol
    Suclg2
  • Name
    succinate-Coenzyme A ligase, GDP-forming, beta subunit
  • Synonyms
    D6Wsu120e
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306824
    NCBI Gene: 20917
  • Alliance
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:95473009-95718800 bp, - strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 44.63 cM, cytoband D3
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1820 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306824
protein coding gene Chr6:95473009-95718858 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031068
protein coding gene Chr6:97265081-97514293 (-)
A/J MGP_AJ_G0031037
protein coding gene Chr6:93582248-93826163 (-)
AKR/J MGP_AKRJ_G0030968
protein coding gene Chr6:96149018-96409818 (-)
BALB/cJ MGP_BALBcJ_G0031048
protein coding gene Chr6:93538717-93776165 (-)
C3H/HeJ MGP_C3HHeJ_G0030660
protein coding gene Chr6:88013407-88265130 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031507
protein coding gene Chr6:99695132-99949879 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028672
protein coding gene Chr6:91517473-91756303 (-)
CAST/EiJ MGP_CASTEiJ_G0030155
protein coding gene Chr6:96369838-96615538 (-)
CBA/J MGP_CBAJ_G0030734
protein coding gene Chr6:103501907-103767684 (-)
DBA/2J MGP_DBA2J_G0030887
protein coding gene Chr6:92730422-92969075 (-)
FVB/NJ MGP_FVBNJ_G0030841
protein coding gene Chr6:91934555-92174617 (-)
LP/J MGP_LPJ_G0030967
protein coding gene Chr6:97266969-97524993 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030875
protein coding gene Chr6:107454874-107700592 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031534
protein coding gene Chr6:96018117-96272574 (-)
PWK/PhJ MGP_PWKPhJ_G0029871
protein coding gene Chr6:91761781-91996926 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029699
protein coding gene Chr6:94958335-95215611 (-)
WSB/EiJ MGP_WSBEiJ_G0030239
protein coding gene Chr6:96492022-96742999 (-)



Homology
more
  • Human Ortholog
    SUCLG2, succinate-CoA ligase GDP-forming beta subunit
  • Vertebrate Orthologs
    9
  • Human Ortholog
    SUCLG2, succinate-CoA ligase GDP-forming beta subunit
    Orthology source: HomoloGene, HGNC
  • Synonyms
    GBETA, G-SCS, GTPSCS
  • Links
    NCBI Gene ID: 8801
    neXtProt AC: NX_Q96I99
    UniProt: Q96I99

  • Chr Location
    3p14.1; chr3:67240957-67654614 (-)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    3 phenotypes from multigenic genotypes
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous knockout with a gene trap is embryonic lethal. Heterozygosity has a mild effect on mitochondrial respiration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000061838 Ensembl Gene Model | MGI Sequence Detail 245792 C57BL/6J ±  kb
transcript ENSMUST00000204224 Ensembl | MGI Sequence Detail 3367 Not Applicable  
polypeptide ENSMUSP00000144827 Ensembl | MGI Sequence Detail 433 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000015813 succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
  • EC
  • InterPro Domains
    IPR005811 ATP-citrate lyase/succinyl-CoA ligase
    IPR011761 ATP-grasp fold
    IPR013815 ATP-grasp fold, subdomain 1
    IPR013650 ATP-grasp fold, succinyl-CoA synthetase-type
    IPR034722 Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial
    IPR005809 Succinate--CoA synthetase, beta subunit
    IPR017866 Succinyl-CoA synthetase, beta subunit, conserved site
    IPR016102 Succinyl-CoA synthetase-like
Molecular
Reagents
less
  • All nucleic 17
    cDNA 15
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-35775, MGI:107309, MGI:2141376, MGI:2141706
References
more
  • Summaries
    All 47
    Developmental Gene Expression 8
    Gene Ontology 7
    Phenotypes 13
  • Earliest
    J:50333 Johnson JD, et al., Genetic evidence for the expression of ATP- and GTP-specific succinyl-CoA synthetases in multicellular eucaryotes. J Biol Chem. 1998 Oct 16;273(42):27580-6
  • Latest
    J:240028 Bulusu V, et al., Spatiotemporal Analysis of a Glycolytic Activity Gradient Linked to Mouse Embryo Mesoderm Development. Dev Cell. 2017 Feb 27;40(4):331-341.e4

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory