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Tff2 Gene Detail
Summary
  • Symbol
    Tff2
  • Name
    trefoil factor 2 (spasmolytic protein 1)
  • Synonyms
    mSP, SP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306805
    NCBI Gene: 21785
  • Gene Overview
    MyGene.info: TFF2
Location & Maps
more
  • Sequence Map
    Chr17:31141049-31144282 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3234 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.80 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    TFF2, trefoil factor 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TFF2, trefoil factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SML1, SP
  • Links
    NCBI Gene ID: 7032
    neXtProt AC: NX_Q03403

  • Chr Location
    21q22.3; chr21:42346357-42351099 (-)  GRCh38.p2

Human Diseases
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  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    11
  • Gene trapped
    2
  • Targeted
    9
  • Genomic Mutations
    4 involving Tff2
  • Incidental Mutations
    APF
Homozygous mutation of this gene results in decreased gastric proliferation, increased acid secretion, increased susceptibility to gastric ulceration after indomethacin administration, and altered regulation of genes involved in adaptive and immune responses in the pyloric antrum.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000020098 VEGA Gene Model | MGI Sequence Detail 3234 C57BL/6J ±  kb
transcript OTTMUST00000047794 VEGA | MGI Sequence Detail 584 Not Applicable  
polypeptide OTTMUSP00000021728 VEGA | MGI Sequence Detail 129 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    150 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
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  • All nucleic 27
    cDNA 24
    Primer pair 3

    Microarray probesets 2
References
more
  • Summaries
    All 51
    Developmental Gene Expression 9
    Diseases 2
    Gene Ontology 8
    Phenotypes 23
  • Earliest
    J:49831 Tomasetto C, et al., hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. EMBO J. 1990 Feb;9(2):407-14
  • Latest
    J:223581 Judd LM, et al., TFF2 deficiency exacerbates weight loss and alters immune cell and cytokine profiles in DSS colitis, and this cannot be rescued by wild-type bone marrow. Am J Physiol Gastrointest Liver Physiol. 2015 Jan 1;308(1):G12-24

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory