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Tff2 Gene Detail
Summary
  • Symbol
    Tff2
  • Name
    trefoil factor 2 (spasmolytic protein 1)
  • Synonyms
    mSP, SP
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306805
    NCBI Gene: 21785
  • Gene Overview
    MyGene.info: TFF2
  • Alliance
Location & Maps
more
  • Sequence Map
    Chr17:31141049-31144282 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      3234 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 17, 15.80 cM
  • Mapping Data
    6 experiments
Homology
more
  • Human Ortholog
    TFF2, trefoil factor 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    TFF2, trefoil factor 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    SML1, SP
  • Links
    NCBI Gene ID: 7032
    neXtProt AC: NX_Q03403
    UniProt: Q03403

  • Chr Location
    21q22.3; chr21:42346357-42351099 (-)  GRCh38.p7

Human Diseases
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  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    8 phenotypes from 2 alleles in 2 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in decreased gastric proliferation, increased acid secretion, increased susceptibility to gastric ulceration after indomethacin administration, and altered regulation of genes involved in adaptive and immune responses in the pyloric antrum.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
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    Representative SequencesLengthStrain/SpeciesFlank
    genomic OTTMUSG00000020098 VEGA Gene Model | MGI Sequence Detail 3234 C57BL/6J ±  kb
    transcript OTTMUST00000047794 VEGA | MGI Sequence Detail 584 Not Applicable  
    polypeptide OTTMUSP00000021728 VEGA | MGI Sequence Detail 129 Not Applicable  
    For the selected sequence
    Polymorphisms
    less
    • SNPs within 2kb
      150 from dbSNP Build 142
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 30
      cDNA 26
      Primer pair 3
      Other 1

      Microarray probesets 2
    References
    more
    • Summaries
      All 74
      Developmental Gene Expression 10
      Diseases 3
      Gene Ontology 7
      Phenotypes 29
    • Earliest
      J:49831 Tomasetto C, et al., hSP, the domain-duplicated homolog of pS2 protein, is co-expressed with pS2 in stomach but not in breast carcinoma. EMBO J. 1990 Feb;9(2):407-14
    • Latest
      J:262380 Watson-Scales S, et al., Analysis of motor dysfunction in Down Syndrome reveals motor neuron degeneration. PLoS Genet. 2018 May;14(5):e1007383

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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    last database update
    10/09/2018
    MGI 6.12
    The Jackson Laboratory