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Itgb1bp1
Gene Detail
 Symbol
Name
ID
Itgb1bp1
integrin beta 1 binding protein 1
MGI:1306802
Synonyms bodenin
Feature Type protein coding gene
Genetic Map
Chromosome 12
8.30 cM
Detailed Genetic Map ± 1 cM


Mapping data(1)
Sequence Map
Chr12:21240825-21286237 bp, - strand
From VEGA annotation of GRCm38

  45413 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:3496  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Itgb1bp1

Human
homologs
Human Homolog ITGB1BP1, integrin beta 1 binding protein 1
NCBI Gene ID 9270
neXtProt AC  NX_O14713
Human Synonyms  ICAP1, ICAP1A, ICAP-1A, ICAP-1alpha, ICAP1B, ICAP-1B
Human Chr (Location)  2p25.2; chr2:9405681-9423564 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(8) : Gene trapped(6) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Mice homozygous for a null allele exhibit postnatal lethality, reduced weight and length, reduced ossification, and skull and skeleton abnormalities. Mice homozygous for a gene trap mutation are viable and do not exhibit any obvious abnormalites.
 
Interactions
Itgb1bp1 interacts with 132 markers (Mir1a-1, Mir9-1, Mir9-2, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (68 annotations)
Process activation of protein kinase B activity, angiogenesis, ...
Component cell periphery, cell projection, ...
Function GDP-dissociation inhibitor activity, integrin binding, ...
External Resources: FuncBase
Expression
Literature Summary: (2 records)
Data Summary: Results (18)    Tissues (2)    Images (18)
Theiler Stages: 23
Assay TypeResults
RNA in situ 18
cDNA source data(13)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(14) cDNA(14)
Microarray probesets(8)
Other database
links
VEGA Gene ModelOTTMUSG00000037686 (Evidence)
Ensembl Gene ModelENSMUSG00000062352 (Evidence)
Entrez Gene16413 (Evidence)
NIA Mouse Gene IndexU142138
Consensus CDS ProjectCCDS25833.1
International Mouse Knockout Project StatusItgb1bp1
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037686 VEGA Gene Model | MGI Sequence Detail 45413 C57BL/6J ±  kb
transcript OTTMUST00000097332 VEGA | MGI Sequence Detail 1874 Not Applicable 
polypeptide OTTMUSP00000054584 VEGA | MGI Sequence Detail 200 Not Applicable 

For the selected sequences
All sequences(52) RefSeq(8) UniProt(3)
Polymorphisms SNPs within 2kb(742 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR019517 Integrin binding protein, ICAP-1
InterPro IPR006020 Phosphotyrosine interaction domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000009136 integrin beta-1-binding protein 1
References (Earliest) J:47964 Faisst AM, et al., Bodenin: a novel murine gene expressed in restricted areas of the brain. Dev Dyn. 1998 Jun;212(2):293-303
(Latest) J:201629 Faurobert E, et al., CCM1-ICAP-1 complex controls beta1 integrin-dependent endothelial contractility and fibronectin remodeling. J Cell Biol. 2013 Aug 5;202(3):545-61
All references(38)
Other
accession IDs
MGI:2144827, MGI:2144948

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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Funding Information
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last database update
09/23/2014
MGI 5.19
The Jackson Laboratory