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Aoc3
Gene Detail
Symbol

Name
ID
Aoc3
amine oxidase, copper containing 3
MGI:1306797
Synonyms
semicarbazide-sensitive amine oxidase, SSAO, VAP1
Feature Type
protein coding gene
Genetic Map
Chromosome 11
64.72 cM, cytoband B2-B5
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr11:101330605-101341938 bp, + strand
From VEGA annotation of GRCm38

  11334 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:2770  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 2 western clawed frog; 1 zebrafish

Protein SuperFamily: amine oxidase (copper-containing)
Gene Tree: Aoc3

Human
homologs
Human Homolog AOC3, amine oxidase, copper containing 3
NCBI Gene ID 8639
neXtProt AC  NX_Q16853
Human Synonyms  HPAO, SSAO, VAP1, VAP-1
Human Chr (Location)  17q21; chr17:42851184-42858130 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(12) : Gene trapped(10) Targeted(2)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous null mice display decreased lymphocyte migration and homing in response to inflammation.
 
Interactions
Aoc3 interacts with 233 markers (Mir1a-1, Mir1a-2, Mir7-1, ...)
Gene Ontology
(GO)
classifications
Expression
Literature Summary: (2 records)
Data Summary: Results (210)    Tissues (165)    Images (37)    Tissue x Stage Matrix (view)
Assay TypeResults
Immunohistochemistry 105
RNA in situ 94
Western blot 11
cDNA source data(18)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(24) Genomic(5) cDNA(18) Primer pair(1)
Microarray probesets(3)
Other database
links
VEGA Gene ModelOTTMUSG00000002793 (Evidence)
Ensembl Gene ModelENSMUSG00000019326 (Evidence)
Entrez Gene11754 (Evidence)
UniGene67281
DFCITC1583528, TC1644987
DoTSDT.101708885, DT.40167744
NIA Mouse Gene IndexU013365
EC1.4.3.21
Consensus CDS ProjectCCDS25465.1
International Mouse Knockout Project StatusAoc3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000002793 VEGA Gene Model | MGI Sequence Detail 11334 C57BL/6J ±  kb
transcript OTTMUST00000005631 VEGA | MGI Sequence Detail 4397 Not Applicable 
polypeptide OTTMUSP00000002692 VEGA | MGI Sequence Detail 765 Not Applicable 

For the selected sequences
All sequences(30) RefSeq(6) UniProt(3)
Polymorphisms
SNPs within 2kb(80 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR000269 Copper amine oxidase
InterPro IPR015798 Copper amine oxidase, C-terminal
InterPro IPR015801 Copper amine oxidase, N2/N3-terminal
InterPro IPR015800 Copper amine oxidase, N2-terminal
InterPro IPR015802 Copper amine oxidase, N3-terminal
InterPro IPR016182 Copper amine oxidase, N-terminal
Protein Ontology PR:000004087 membrane primary amine oxidase
References
(Earliest) J:47790 Bono P, et al., Cloning and characterization of mouse vascular adhesion protein-1 reveals a novel molecule with enzymatic activity. J Immunol. 1998 Jun 1;160(11):5563-71
(Latest) J:196458 Ferjancic S, et al., VCAM-1 and VAP-1 recruit myeloid cells that promote pulmonary metastasis in mice. Blood. 2013 Apr 18;121(16):3289-97
All references(43)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/21/2014
MGI 5.20
The Jackson Laboratory