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Akap2 Gene Detail
Summary
  • Symbol
    Akap2
  • Name
    A kinase (PRKA) anchor protein 2
  • Synonyms
    AKAP-KL, B230340M18Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306795
    NCBI Gene: 11641
  • Gene Overview
    MyGene.info: AKAP2
  • Alliance
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:57845248-57896984 bp, + strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 4, 31.79 cM
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    427 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1306795
protein coding gene Chr4:57717657-57896984 (.)
129S1/SvImJ MGP_129S1SvImJ_G0028319
protein coding gene Chr4:56528778-56708280 (+)
A/J MGP_AJ_G0028280
protein coding gene Chr4:54374090-54554984 (+)
AKR/J MGP_AKRJ_G0028229
protein coding gene Chr4:55877559-56060399 (+)
BALB/cJ MGP_BALBcJ_G0028299
protein coding gene Chr4:54536082-54716961 (+)
C3H/HeJ MGP_C3HHeJ_G0028020
protein coding gene Chr4:56384951-56569846 (+)
C57BL/6NJ MGP_C57BL6NJ_G0028740
protein coding gene Chr4:58541164-58734461 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0026046
protein coding gene Chr4:51158510-51332231 (+)
CAST/EiJ MGP_CASTEiJ_G0027458
protein coding gene Chr4:56112219-56300929 (+)
CBA/J MGP_CBAJ_G0027985
protein coding gene Chr4:60550030-60729786 (+)
DBA/2J MGP_DBA2J_G0028135
protein coding gene Chr4:54273915-54453051 (+)
FVB/NJ MGP_FVBNJ_G0028102
protein coding gene Chr4:53503556-53679576 (+)
LP/J MGP_LPJ_G0028234
protein coding gene Chr4:56632030-56822517 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0028126
protein coding gene Chr4:63674409-63865090 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0028776
protein coding gene Chr4:56073479-56265866 (+)
PWK/PhJ MGP_PWKPhJ_G0027183
protein coding gene Chr4:54273938-54455789 (+)
SPRET/EiJ MGP_SPRETEiJ_G0027011
protein coding gene Chr4:55345859-55535835 (+)
WSB/EiJ MGP_WSBEiJ_G0027536
protein coding gene Chr4:56020081-56215101 (+)



Homology
more
  • Human Ortholog
    AKAP2, A-kinase anchoring protein 2
  • Vertebrate Orthologs
    7
  • Human Ortholog
    AKAP2, A-kinase anchoring protein 2
    Orthology source: HGNC, HomoloGene
  • Synonyms
    AKAP-2, AKAPKL, MISP2, PRKA2
  • Links
    NCBI Gene ID: 11217
    neXtProt AC: NX_Q9Y2D5
    UniProt: Q9Y2D5

  • Chr Location
    9q31.3; chr9:110048598-110172512 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    2 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 11641 NCBI Gene Model | MGI Sequence Detail 51737 C57BL/6J ±  kb
transcript NM_001035532 RefSeq | MGI Sequence Detail 6830 C57BL/6  
polypeptide O54931 UniProt | EBI | MGI Sequence Detail 893 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    1 Sequence
Molecular
Reagents
less
  • All nucleic 20
    cDNA 20

    Microarray probesets 5
Other
Accession IDs
less
MGI:2140178, MGI:2140348, MGI:2443506
References
more
  • Summaries
    All 26
    Developmental Gene Expression 4
    Gene Ontology 3
    Phenotypes 2
  • Earliest
    J:46555 Dong F, et al., Molecular characterization of a cDNA that encodes six isoforms of a novel murine A kinase anchor protein. J Biol Chem. 1998 Mar 13;273(11):6533-41
  • Latest
    J:231595 Gurdziel K, et al., Transcriptome of the inner circular smooth muscle of the developing mouse intestine: Evidence for regulation of visceral smooth muscle genes by the hedgehog target gene, cJun. Dev Dyn. 2016 May;245(5):614-26

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
12/04/2018
MGI 6.13
The Jackson Laboratory