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Scin Gene Detail
Summary
  • Symbol
    Scin
  • Name
    scinderin
  • Synonyms
    adseverin
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306794
    NCBI Gene: 20259
  • Gene Overview
    MyGene.info: SCIN
Location & Maps
more
  • Sequence Map
    Chr12:40059769-40134228 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      74460 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    SCIN, scinderin
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SCIN, scinderin
    Orthology source: HGNC, HomoloGene
  • Links
    NCBI Gene ID: 85477
    neXtProt AC: NX_Q9Y6U3

  • Chr Location
    7p21.3; chr7:12570349-12653603 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 36296
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SCIN
  • Protein SuperFamily
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from multigenic genotypes
    4 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (ENU)
    1
  • Targeted
    3
  • Incidental Mutations
Mice homozygous for a conditional allele knocked-out in osteoclasts exhibit impaired osteoclast differentiation and reduced peridontal disease-mediated bone loss.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000027556 VEGA Gene Model | MGI Sequence Detail 74460 C57BL/6J ±  kb
transcript OTTMUST00000068239 VEGA | MGI Sequence Detail 2995 Not Applicable  
polypeptide OTTMUSP00000034450 VEGA | MGI Sequence Detail 715 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    331 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 38
    cDNA 38

    Microarray probesets 3
Other
Accession IDs
less
MGI:2145036
References
more
  • Summaries
    All 33
    Developmental Gene Expression 4
    Gene Ontology 5
    Phenotypes 4
  • Earliest
    J:48640 Robbens J, et al., Murine adseverin (D5), a novel member of the gelsolin family, and murine adseverin are induced by interleukin-9 in T-helper lymphocytes. Mol Cell Biol. 1998 Aug;18(8):4589-96
  • Latest
    J:223220 Jiang H, et al., Adseverin plays a role in osteoclast differentiation and periodontal disease-mediated bone loss. FASEB J. 2015 Jun;29(6):2281-91

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory