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Egr3
Gene Detail
Symbol

Name
ID
Egr3
early growth response 3
MGI:1306780
Synonyms
Pilot
Feature Type
protein coding gene
Genetic Map
Chromosome 14
36.20 cM, cytoband D1
Detailed Genetic Map ± 1 cM


Mapping data(2)
Sequence Map
Chr14:70077445-70080157 bp, + strand
From Ensembl annotation of GRCm38

  2713 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:37923  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

HCOP human homology predictions: EGR3
Gene Tree: Egr3

Human
homologs
EGR3, early growth response 3
Orthology source: HGNC, HomoloGene

IDs:
NCBI Gene ID: 1960
neXtProt AC: NX_Q06889

Human Synonyms: EGR-3, PILOT

Human Chr (Location): 8p23-p21; chr8:22687659-22693302 (-)  GRCh38.p2

Mutations,
alleles, and
phenotypes
All mutations/alleles(6) : Targeted(6)
Incidental mutations (data from APF )
 
Homozygous null mutants exhibit partial postnatal lethality, sensory ataxia, resting tremors, blepharoptosis, scoliosis, muscle spindle agenesis, loss of myelinated proprioceptive neurons, and a defect in the strength of sensory-motor connections.
 
Interactions
Egr3 interacts with 44 markers (Mir30a, Mir30d, Mir30e, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (22 annotations)
Process cell migration involved in sprouting angiogenesis, cellular response to cAMP, ...
Component cytoplasm, nucleus
Function DNA binding, metal ion binding, ...
External Resources: FuncBase
Expression
Literature Summary: (17 records)
Data Summary: Results (98)    Tissues (53)    Images (22)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 98
cDNA source data(9)
Other mouse links: Allen Institute   GEO   Expression Atlas
Other vertebrate links: Xenbase egr3    NEW 
Molecular
reagents
All nucleic(11) Genomic(1) cDNA(10)
Microarray probesets(3)
Other database
links
Ensembl Gene Model ENSMUSG00000033730 (Evidence)
Entrez Gene 13655 (Evidence)
DFCI TC1596950, TC1677347, TC1678877
DoTS DT.101375152, DT.110754371, DT.40164250, DT.55248734
NIA Mouse Gene Index U015814
Consensus CDS Project CCDS27246.1
International Mouse Phenotyping Consortium Status Egr3
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000033730 Ensembl Gene Model | MGI Sequence Detail 2713 C57BL/6J ±  kb
transcript ENSMUST00000035908 Ensembl | MGI Sequence Detail 1416 Not Applicable 
polypeptide ENSMUSP00000037042 Ensembl | MGI Sequence Detail 387 Not Applicable 

For the selected sequences
All sequences(36) RefSeq(8) UniProt(4)
Polymorphisms
SNPs within 2kb(8 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR021849 Protein of unknown function DUF3446
InterPro IPR007087 Zinc finger, C2H2
InterPro IPR015880 Zinc finger, C2H2-like
InterPro IPR013087 Zinc finger C2H2-type/integrase DNA-binding domain
Protein Ontology PR:000006939 early growth response protein 3
References
(Earliest) J:49519 Patwardhan S, et al., EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors. Oncogene. 1991 Jun;6(6):917-28
(Latest) J:219203 Takeoka A, et al., Muscle spindle feedback directs locomotor recovery and circuit reorganization after spinal cord injury. Cell. 2014 Dec 18;159(7):1626-39
All references(68)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
08/25/2015
MGI 6.0
The Jackson Laboratory