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Map1a Gene Detail
Summary
  • Symbol
    Map1a
  • Name
    microtubule-associated protein 1 A
  • Synonyms
    6330416M19Rik, Mtap1, Mtap-1, Mtap1a
  • Feature Type
    protein coding gene
  • IDs
    MGI:1306776
    NCBI Gene: 17754
  • Gene Overview
    MyGene.info: MAP1A
Location & Maps
more
  • Sequence Map
    Chr2:121289600-121310832 bp, + strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      21233 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 2, 60.37 cM
  • Mapping Data
    16 experiments
Homology
more
  • Human Ortholog
    MAP1A, microtubule associated protein 1A
  • Vertebrate Orthologs
    8
  • Human Ortholog
    MAP1A, microtubule associated protein 1A
    Orthology source: HGNC, HomoloGene
  • Synonyms
    MAP1L, MTAP1A
  • Links
    NCBI Gene ID: 4130
    neXtProt AC: NX_P78559

  • Chr Location
    15q15.3; chr15:43517608-43531620 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    10 phenotypes from 4 alleles in 5 genetic backgrounds
    14 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    25
  • Chemically induced (other)
    1
  • Gene trapped
    17
  • QTL
    2
  • Radiation induced
    1
  • Spontaneous
    1
  • Targeted
    3
  • Genomic Mutations
    2 involving Map1a
  • Incidental Mutations
    APF , CvDC
Mice homozygous for a knock-out allele exhibit Purkinje cell degeneration. Mice homozygous for a spontaneous mutation exhibit mild ataxia and Purkinje cell degeneration.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000015225 VEGA Gene Model | MGI Sequence Detail 21233 C57BL/6J ±  kb
transcript OTTMUST00000036069 VEGA | MGI Sequence Detail 11825 Not Applicable  
polypeptide OTTMUSP00000016203 VEGA | MGI Sequence Detail 3014 Not Applicable  
For the selected sequence
Polymorphisms
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  • SNPs within 2kb
    98 from dbSNP Build 142
  • RFLP
Protein
Information
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  • UniProt
    2 Sequences
  • Protein Ontology
    PR:000010116 microtubule-associated protein 1A
  • InterPro Domains
    IPR001279 Metallo-beta-lactamase
    IPR026074 Microtubule associated protein 1
    IPR015656 Microtubule associated protein 1A
Molecular
Reagents
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  • All nucleic 11
    cDNA 10
    Other 1

    Microarray probesets 5
Other
Accession IDs
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MGD-MRK-12579, MGD-MRK-12584, MGI:1346024, MGI:1921253, MGI:2139097, MGI:97174
References
more
  • Summaries
    All 57
    Developmental Gene Expression 3
    Gene Ontology 10
    Phenotypes 14
  • Earliest
    J:10560 Garner CC, et al., Molecular cloning of microtubule-associated protein 1 (MAP1A) and microtubule-associated protein 5 (MAP1B): identification of distinct genes and their differential expression in developing brain. J Neurochem. 1990 Jul;55(1):146-54
  • Latest
    J:220153 Liu Y, et al., Mutations in the Microtubule-Associated Protein 1A (Map1a) Gene Cause Purkinje Cell Degeneration. J Neurosci. 2015 Mar 18;35(11):4587-98

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory