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Mcm7
Gene Detail
Symbol

Name
ID
Mcm7
minichromosome maintenance deficient 7 (S. cerevisiae)
MGI:1298398
Synonyms
mCDC47, Mcmd7
Feature Type
protein coding gene
Genetic Map
Chromosome 5
76.97 cM, cytoband G1
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr5:138164583-138172422 bp, - strand
From VEGA annotation of GRCm38

  7840 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:4323  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 western clawed frog; 1 zebrafish

Protein SuperFamily: replication licensing factor MCM7
Gene Tree: Mcm7

Human
homologs
Human Homolog MCM7, minichromosome maintenance complex component 7
NCBI Gene ID 4176
neXtProt AC  NX_P33993
Human Synonyms  CDC47, MCM2, P1.1-MCM3, P1CDC47, P85MCM, PNAS146, PPP1R104
Human Chr (Location)  7q21.3-q22.1; chr7:100092728-100101940 (-)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(71) : Gene trapped(68) Targeted(3)
 
Mice homozygous for a gene trapped allele exhibit prenatal lethality. Mice heterozygous for this allele exhibit increased micronulei-containing red blood cells.
 
Interactions
Mcm7 interacts with 48 markers (Mir17, Mir20a, Mir20b, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (27 annotations)
Process cell cycle, cell proliferation, ...
Component cytoplasm, cytosol, ...
Function ATP binding, ATP-dependent DNA helicase activity, ...
External Resources: FuncBase
Expression
Literature Summary: (7 records)
Data Summary: Results (173)    Tissues (169)    Images (24)    Tissue x Stage Matrix (view)
Assay TypeResults
RNA in situ 127
RT-PCR 46
cDNA source data(163)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(165) cDNA(163) Primer pair(2)
Microarray probesets(4)
Other database
links
VEGA Gene ModelOTTMUSG00000022672 (Evidence)
Ensembl Gene ModelENSMUSG00000029730 (Evidence)
Entrez Gene17220 (Evidence)
UniGene378965
NIA Mouse Gene IndexU026865, U146632
EC3.6.4.12
Consensus CDS ProjectCCDS19793.1
International Mouse Knockout Project StatusMcm7
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000022672 VEGA Gene Model | MGI Sequence Detail 7840 C57BL/6J ±  kb
transcript OTTMUST00000054327 VEGA | MGI Sequence Detail 2962 Not Applicable 
polypeptide OTTMUSP00000025921 VEGA | MGI Sequence Detail 719 Not Applicable 

For the selected sequences
All sequences(72) RefSeq(8) UniProt(8)
Polymorphisms
SNPs within 2kb(81 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR003593 AAA+ ATPase domain
InterPro IPR008050 DNA replication licensing factor Mcm7
InterPro IPR018525 Mini-chromosome maintenance, conserved site
InterPro IPR001208 Mini-chromosome maintenance, DNA-dependent ATPase
InterPro IPR012340 Nucleic acid-binding, OB-fold
InterPro IPR027417 P-loop containing nucleoside triphosphate hydrolase
Protein Ontology PR:000010249 DNA replication licensing factor MCM7
References
(Earliest) J:30650 Takizawa N, et al., Sequence of mouse CDC47, a member of the minichromosome maintenance (Mcm) family involved in the DNA replication licensing system. Gene. 1995 Dec 29;167(1-2):343-4
(Latest) J:192413 Ortega MA, et al., Unique pattern of ORC2 and MCM7 localization during DNA replication licensing in the mouse zygote. Biol Reprod. 2012 Sep;87(3):62
All references(59)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory