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Swap70
Gene Detail
Symbol

Name
ID
Swap70
SWA-70 protein
MGI:1298390
Synonyms
70kDa
Feature Type
protein coding gene
Genetic Map
Chromosome 7
57.70 cM
Detailed Genetic Map ± 1 cM


Mapping data(4)
Sequence Map
Chr7:110221703-110283503 bp, + strand
From Ensembl annotation of GRCm38

  61801 bp   ±  kb flank

VEGA Genome Browser | Ensembl Genome Browser | UCSC Browser | NCBI Map Viewer


Mouse Genome Browser
Vertebrate
homology
HomoloGene:7557  Vertebrate Homology Class
1 human; 1 mouse; 1 rat; 1 chimpanzee; 1 rhesus macaque; 1 cattle; 1 dog; 1 chicken; 1 western clawed frog; 1 zebrafish

Gene Tree: Swap70

Human
homologs
Human Homolog SWAP70, SWAP switching B-cell complex 70kDa subunit
NCBI Gene ID 23075
neXtProt AC  NX_Q9UH65
Human Synonyms  SWAP-70
Human Chr (Location)  11p15; chr11:9664077-9752961 (+)  GRCh38
Mutations,
alleles, and
phenotypes
All mutations/alleles(22) : Gene trapped(21) Targeted(1)
Incidental mutations (data from Mutagenetix , APF )
 
Homozygous mutation of this gene results in increased sensitivity of B lymphocytes to gamma-radiation, increased autoantibody levels, and lower IgE levels, both before and after immunization.
 
Interactions
Swap70 interacts with 233 markers (Mir7-1, Mir10b, Mir15a, ...)
Gene Ontology
(GO)
classifications
All GO classifications: (10 annotations)
Process isotype switching, somatic cell DNA recombination
Component cell projection, cytoplasm, ...
Function ATP binding, DNA binding, ...
External Resources: FuncBase
Expression
Literature Summary: (1 records)
cDNA source data(75)
External Resources: Allen Institute   GEO   Expression Atlas
Molecular
reagents
All nucleic(76) Genomic(1) cDNA(75)
Microarray probesets(4)
Other database
links
Ensembl Gene ModelENSMUSG00000031015 (Evidence)
Entrez Gene20947 (Evidence)
UniGene334144
DFCITC1575294, TC1606516
DoTSDT.101267333, DT.102550461, DT.486761
NIA Mouse Gene IndexU042853
Consensus CDS ProjectCCDS21744.1
International Mouse Knockout Project StatusSwap70
Sequences
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031015 Ensembl Gene Model | MGI Sequence Detail 61801 C57BL/6J ±  kb
transcript ENSMUST00000033325 Ensembl | MGI Sequence Detail 4032 Not Applicable 
polypeptide ENSMUSP00000033325 Ensembl | MGI Sequence Detail 585 Not Applicable 

For the selected sequences
All sequences(27) RefSeq(2) UniProt(1)
Polymorphisms
RFLP(1) : SNPs within 2kb(689 from dbSNP Build 137)
Protein-related
information
ResourceIDDescription
InterPro IPR001849 Pleckstrin homology domain
InterPro IPR011993 Pleckstrin homology-like domain
Protein Ontology PR:000015856 switch-associated protein 70
References
(Earliest) J:48490 Borggrefe T, et al., A B-cell-specific DNA recombination complex. J Biol Chem. 1998 Jul 3;273(27):17025-35
(Latest) J:207250 Chacon-Martinez CA, et al., The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics. J Biol Chem. 2013 Oct 4;288(40):28687-703
All references(49)
Other
accession IDs
MGI:2142179

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
10/08/2014
MGI 5.20
The Jackson Laboratory