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Swap70 Gene Detail
Summary
  • Symbol
    Swap70
  • Name
    SWA-70 protein
  • Synonyms
    70kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298390
    NCBI Gene: 20947
  • Gene Overview
    MyGene.info: SWAP70
Location & Maps
more
  • Sequence Map
    Chr7:110221703-110283503 bp, + strand
  • From Ensembl annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      61801 bp   ±  kb flank

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.70 cM
  • Detailed Genetic Map ± 1 cM
  • Mapping Data
    4 experiments
Homology
more
  • Human Ortholog
    SWAP70, SWAP switching B-cell complex 70kDa subunit
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SWAP70, SWAP switching B-cell complex 70kDa subunit
    Orthology source: HGNC, HomoloGene
  • Synonyms
    HSPC321, SWAP-70
  • Links
    NCBI Gene ID: 23075
    neXtProt AC: NX_Q9UH65

  • Chr Location
    11p15; chr11:9664077-9752991 (+)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 7557
    1 human;1 mouse;1 rat;1 chimpanzee;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: SWAP70
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryogenesis
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
tumorigenesis
vision/eye

Click cells to view annotations.
  • All Mutations and Alleles
    24
  • Chemically induced (other)
    1
  • Gene trapped
    21
  • Radiation induced
    1
  • Targeted
    1
  • Genomic Mutations
    2 involving Swap70
  • Incidental Mutations
Homozygous mutation of this gene results in increased sensitivity of B lymphocytes to gamma-radiation, increased autoantibody levels, and lower IgE levels, both before and after immunization.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031015 Ensembl Gene Model | MGI Sequence Detail 61801 C57BL/6J ±  kb
transcript ENSMUST00000033325 Ensembl | MGI Sequence Detail 4032 Not Applicable  
polypeptide ENSMUSP00000033325 Ensembl | MGI Sequence Detail 585 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    689 from dbSNP Build 142
  • RFLP
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 76
    Genomic 1
    cDNA 75

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142179
References
more
  • Summaries
    All 45
    Developmental Gene Expression 1
    Gene Ontology 5
    Phenotypes 28
  • Earliest
    J:48490 Borggrefe T, et al., A B-cell-specific DNA recombination complex. J Biol Chem. 1998 Jul 3;273(27):17025-35
  • Latest
    J:207250 Chacon-Martinez CA, et al., The switch-associated protein 70 (SWAP-70) bundles actin filaments and contributes to the regulation of F-actin dynamics. J Biol Chem. 2013 Oct 4;288(40):28687-703

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/24/2016
MGI 6.04
The Jackson Laboratory