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Swap70 Gene Detail
Summary
  • Symbol
    Swap70
  • Name
    SWA-70 protein
  • Synonyms
    70kDa
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298390
    NCBI Gene: 20947
  • Gene Overview
    MyGene.info: SWAP70
  • Alliance
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:110221711-110283506 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 7, 57.70 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    689 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298390
protein coding gene Chr7:110221703-110283506 (.)
129S1/SvImJ MGP_129S1SvImJ_G0032856
protein coding gene Chr7:113697923-113762098 (+)
A/J MGP_AJ_G0032840
protein coding gene Chr7:110871898-110933369 (+)
AKR/J MGP_AKRJ_G0032771
protein coding gene Chr7:113660940-113725753 (+)
BALB/cJ MGP_BALBcJ_G0032844
protein coding gene Chr7:110571351-110634333 (+)
C3H/HeJ MGP_C3HHeJ_G0032554
protein coding gene Chr7:113683441-113746949 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033350
protein coding gene Chr7:118407860-118476772 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030322
protein coding gene Chr7:112451946-112511952 (+)
CAST/EiJ MGP_CASTEiJ_G0031882
protein coding gene Chr7:105249718-105315411 (+)
CBA/J MGP_CBAJ_G0032527
protein coding gene Chr7:122276887-122338679 (+)
DBA/2J MGP_DBA2J_G0032679
protein coding gene Chr7:108978485-109040249 (+)
FVB/NJ MGP_FVBNJ_G0032632
protein coding gene Chr7:108835572-108898001 (+)
LP/J MGP_LPJ_G0032773
protein coding gene Chr7:115236412-115300574 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032664
protein coding gene Chr7:123917849-123981006 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033371
protein coding gene Chr7:112670497-112733764 (+)
PWK/PhJ MGP_PWKPhJ_G0031589
protein coding gene Chr7:101801955-101865058 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031437
protein coding gene Chr7:99363485-99424767 (+)
WSB/EiJ MGP_WSBEiJ_G0031995
protein coding gene Chr7:113530353-113594942 (+)



Homology
more
  • Human Ortholog
    SWAP70, switching B cell complex subunit SWAP70
  • Vertebrate Orthologs
    10
  • Human Ortholog
    SWAP70, switching B cell complex subunit SWAP70
    Orthology source: HomoloGene, HGNC
  • Synonyms
    HSPC321, SWAP-70
  • Links
    NCBI Gene ID: 23075
    neXtProt AC: NX_Q9UH65
    UniProt: Q9UH65

  • Chr Location
    11p15.4; chr11:9664077-9752991 (+)  GRCh38.p7

  • HomoloGene
    Vertebrate Homology Class 7557
    1 human;1 mouse;1 rat;1 chimpanzee;1 cattle;1 dog;1 chicken;1 zebrafish;1 frog, western clawed;1 macaque, rhesus
  • HCOP
    human homology predictions: SWAP70
  • Gene Tree
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in increased sensitivity of B lymphocytes to gamma-radiation, increased autoantibody levels, and lower IgE levels, both before and after immunization.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031015 Ensembl Gene Model | MGI Sequence Detail 61796 C57BL/6J ±  kb
transcript ENSMUST00000033325 Ensembl | MGI Sequence Detail 4027 Not Applicable  
polypeptide ENSMUSP00000033325 Ensembl | MGI Sequence Detail 585 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 77
    Genomic 1
    cDNA 76

    Microarray probesets 4
Other
Accession IDs
less
MGI:2142179
References
more
  • Summaries
    All 63
    Developmental Gene Expression 1
    Gene Ontology 8
    Phenotypes 31
  • Earliest
    J:88307 Giometti CS, et al., The analysis of recessive lethal mutations in mice by using two-dimensional gel electrophoresis of liver proteins. Mutat Res. 1990 Sep;242(1):47-55
  • Latest
    J:254902 Yi W, et al., The mTORC1-4E-BP-eIF4E axis controls de novo Bcl6 protein synthesis in T cells and systemic autoimmunity. Nat Commun. 2017 Aug 15;8(1):254

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
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last database update
11/06/2018
MGI 6.13
The Jackson Laboratory