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Clec4d Gene Detail
Summary
  • Symbol
    Clec4d
  • Name
    C-type lectin domain family 4, member d
  • Synonyms
    Clecsf8, mcl, mMCL, Mpcl
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298389
    NCBI Gene: 17474
  • Alliance
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:123262111-123275265 bp, + strand
  • From Ensembl annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome 6, 58.33 cM, cytoband F3
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    110 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298389
protein coding gene Chr6:123262107-123275268 (+)
129S1/SvImJ MGP_129S1SvImJ_G0031243
protein coding gene Chr6:126414584-126427757 (+)
A/J MGP_AJ_G0031212
protein coding gene Chr6:121577041-121590191 (+)
AKR/J MGP_AKRJ_G0031142
protein coding gene Chr6:124954720-124967866 (+)
BALB/cJ MGP_BALBcJ_G0031222
protein coding gene Chr6:121305765-121318915 (+)
C3H/HeJ MGP_C3HHeJ_G0030941
protein coding gene Chr6:124913504-124926646 (+)
C57BL/6NJ MGP_C57BL6NJ_G0031681
protein coding gene Chr6:129742725-129755879 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028837
protein coding gene Chr6:118144435-118157712 (+)
CAST/EiJ MGP_CASTEiJ_G0030330
protein coding gene Chr6:125165665-125178761 (+)
CBA/J MGP_CBAJ_G0030904
protein coding gene Chr6:134821223-134834367 (+)
DBA/2J MGP_DBA2J_G0031060
protein coding gene Chr6:120539652-120552798 (+)
FVB/NJ MGP_FVBNJ_G0031012
protein coding gene Chr6:119465582-119478745 (+)
LP/J MGP_LPJ_G0031141
protein coding gene Chr6:126588140-126601329 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0031048
protein coding gene Chr6:138745951-138759096 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031710
protein coding gene Chr6:124855789-124868935 (+)
PWK/PhJ MGP_PWKPhJ_G0030044
protein coding gene Chr6:119358848-119372148 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029872
protein coding gene Chr6:122992641-123007063 (+)
WSB/EiJ MGP_WSBEiJ_G0030412
protein coding gene Chr6:125148302-125161814 (+)



Homology
more
  • Human Ortholog
    CLEC4D, C-type lectin domain family 4 member D
  • Vertebrate Orthologs
    7
  • Human Ortholog
    CLEC4D, C-type lectin domain family 4 member D
    Orthology source: HomoloGene, HGNC
  • Synonyms
    CD368, CLEC6, CLEC-6, CLECSF8, Dectin-3, MCL, MPCL
  • Links
    NCBI Gene ID: 338339
    neXtProt AC: NX_Q8WXI8
    UniProt: Q8WXI8

  • Chr Location
    12p13.31; chr12:8513492-8522366 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    31 phenotypes from 2 alleles in 2 genetic backgrounds
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit decreased sensitivity to trehalose-6,60'-dimycolate treatment. Mice homozygous for a different knock-out allele exhibit increased susceptibility to pneumonia infection.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell population proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
  • Comparison Matrix
  • Interactions
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    Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030144 Ensembl Gene Model | MGI Sequence Detail 13155 C57BL/6J ±  kb
    transcript ENSMUST00000032240 Ensembl | MGI Sequence Detail 1323 Not Applicable  
    polypeptide ENSMUSP00000032240 Ensembl | MGI Sequence Detail 219 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 1
      cDNA 14

      Microarray probesets 3
    References
    more
    • Summaries
      All 41
      Developmental Gene Expression 1
      Gene Ontology 2
      Phenotypes 16
    • Earliest
      J:48677 Balch SG, et al., Cloning of a novel C-type lectin expressed by murine macrophages. J Biol Chem. 1998 Jul 17;273(29):18656-64
    • Latest
      J:272677 Hernandez-Santos N, et al., Lung Epithelial Cells Coordinate Innate Lymphocytes and Immunity against Pulmonary Fungal Infection. Cell Host Microbe. 2018 Apr 11;23(4):511-522.e5

    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    last database update
    05/14/2019
    MGI 6.14
    The Jackson Laboratory