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Plp2 Gene Detail
Summary
  • Symbol
    Plp2
  • Name
    proteolipid protein 2
  • Synonyms
    mIMA4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298382
    NCBI Gene: 18824
  • Gene Overview
    MyGene.info: PLP2
  • Alliance
Location &
Maps
more
  • Sequence Map
    ChrX:7667941-7671390 bp, - strand
  • From NCBI annotation of GRCm38

    View this region in JBrowse

  • Genome Browsers
  • Genetic Map
    Chromosome X, 3.45 cM, cytoband A2-A3.1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    31 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298382
protein coding gene ChrX:7667941-7671390 (-)
129S1/SvImJ MGP_129S1SvImJ_G0035517
protein coding gene ChrX:2279789-2284051 (-)
A/J MGP_AJ_G0035495
protein coding gene ChrX:2243380-2246395 (-)
AKR/J MGP_AKRJ_G0035428
protein coding gene ChrX:2346039-2351842 (-)
BALB/cJ MGP_BALBcJ_G0035491
protein coding gene ChrX:2259011-2266135 (-)
C3H/HeJ MGP_C3HHeJ_G0035199
protein coding gene ChrX:2313680-2316878 (-)
C57BL/6NJ MGP_C57BL6NJ_G0036015
protein coding gene ChrX:2355724-2358866 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032890
protein coding gene ChrX:1808702-1812195 (-)
CAST/EiJ MGP_CASTEiJ_G0034499
protein coding gene ChrX:2216344-2220291 (-)
CBA/J MGP_CBAJ_G0035169
protein coding gene ChrX:2474944-2485437 (-)
DBA/2J MGP_DBA2J_G0035326
protein coding gene ChrX:2263697-2267228 (-)
FVB/NJ MGP_FVBNJ_G0035273
protein coding gene ChrX:2225138-2228666 (-)
LP/J MGP_LPJ_G0035403
protein coding gene ChrX:2281442-2284859 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0035312
protein coding gene ChrX:2437671-2442471 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0036033
protein coding gene ChrX:2269361-2272778 (-)
PWK/PhJ MGP_PWKPhJ_G0034201
protein coding gene ChrX:2195892-2205108 (-)
SPRET/EiJ MGP_SPRETEiJ_G0034038
protein coding gene ChrX:2234474-2237904 (-)
WSB/EiJ MGP_WSBEiJ_G0034622
protein coding gene ChrX:2269815-2274352 (-)



Homology
more
  • Human Ortholog
    PLP2, proteolipid protein 2
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PLP2, proteolipid protein 2
    Orthology source: HomoloGene, HGNC
  • Synonyms
    A4, A4LSB
  • Links
    NCBI Gene ID: 5355
    neXtProt AC: NX_Q04941
    UniProt: Q04941

  • Chr Location
    Xp11.23; chrX:49171837-49175120 (+)  GRCh38.p7

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotypes from 1 allele in 1 genetic background
    8 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
immune system
integument
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
neoplasm
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
vision/eye

Click cells to view annotations.
Males hemizygous for a null allele show increased neuronal apoptosis to ER stress and hypoxia in vitro and in a neonatal hypoxia-ischemia model in vivo. Mutant mouse embryonic fibroblasts show delayed ER trafficking, increased basal ER stress and increased sensitivity to ER stress-induced apoptosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
nucleic acid-templated transcription
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 18824 NCBI Gene Model | MGI Sequence Detail 3450 C57BL/6J ±  kb
transcript NM_019755 RefSeq | MGI Sequence Detail 1178 C57BL/6  
polypeptide NP_062729 RefSeq | MGI Sequence Detail 152 C57BL/6  
For the selected sequence
Molecular
Reagents
less
  • All nucleic 22
    Genomic 5
    cDNA 17

    Microarray probesets 6
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 2
    Phenotypes 8
  • Earliest
    J:49742 Kuroiwa A, et al., Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes. Cytogenet Cell Genet. 1998;81(3-4):208-12
  • Latest
    J:227053 Zhang L, et al., Reduced PLP2 expression increases ER-stress-induced neuronal apoptosis and risk for adverse neurological outcomes after hypoxia ischemia injury. Hum Mol Genet. 2015 Dec 20;24(25):7221-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
11/13/2018
MGI 6.13
The Jackson Laboratory