About   Help   FAQ
Plp2 Gene Detail
Summary
  • Symbol
    Plp2
  • Name
    proteolipid protein 2
  • Synonyms
    mIMA4
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298382
    NCBI Gene: 18824
  • Gene Overview
    MyGene.info: PLP2
Location & Maps
more
Homology
more
  • Human Ortholog
    PLP2, proteolipid protein 2 (colonic epithelium-enriched)
  • Vertebrate Orthologs
    8
  • Human Ortholog
    PLP2, proteolipid protein 2 (colonic epithelium-enriched)
    Orthology source: HGNC, HomoloGene
  • Synonyms
    A4, A4LSB
  • Links
    NCBI Gene ID: 5355
    neXtProt AC: NX_Q04941

  • Chr Location
    Xp11.23; chrX:49171837-49175120 (+)  GRCh38.p2

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotype references
  • All Mutations and Alleles
    16
  • Gene trapped
    12
  • Targeted
    4
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
less
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000017753 VEGA Gene Model | MGI Sequence Detail 3450 C57BL/6J ±  kb
transcript OTTMUST00000042983 VEGA | MGI Sequence Detail 1157 Not Applicable  
polypeptide OTTMUSP00000019327 VEGA | MGI Sequence Detail 152 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    31 from dbSNP Build 142
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 5
    cDNA 16

    Microarray probesets 6
References
more
  • Summaries
    All 29
    Developmental Gene Expression 3
    Gene Ontology 1
    Phenotypes 8
  • Earliest
    J:49742 Kuroiwa A, et al., Comparative FISH mapping of mouse and rat homologues of twenty-five human X-linked genes. Cytogenet Cell Genet. 1998;81(3-4):208-12
  • Latest
    J:227053 Zhang L, et al., Reduced PLP2 expression increases ER-stress-induced neuronal apoptosis and risk for adverse neurological outcomes after hypoxia ischemia injury. Hum Mol Genet. 2015 Dec 20;24(25):7221-6

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
05/17/2016
MGI 6.03
The Jackson Laboratory