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Ddt Gene Detail
Summary
  • Symbol
    Ddt
  • Name
    D-dopachrome tautomerase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298381
    NCBI Gene: 13202
  • Alliance
    genome feature page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:75607067-75609208 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 38.58 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    165 from dbSNP Build 142
  • Strain Annotations
    14
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_1298381
 protein coding gene Chr10:75607064-75609248 (-)
129S1/SvImJ ENSMUSG00200041817
 protein coding gene Chr10:72308560-72310744 (-)
A/J ENSMUSG00195045444
 protein coding gene Chr10:72620667-72622853 (-)
AKR/J ENSMUSG00220041580
 protein coding gene Chr10:72280428-72282612 (-)
BALB/cJ ENSMUSG00180051556
 protein coding gene Chr10:72635138-72637325 (-)
C3H/HeJ ENSMUSG00175041426
 protein coding gene Chr10:72506488-72508673 (-)
C57BL/6NJ ENSMUSG00215049594
 protein coding gene Chr10:72244068-72246254 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015447
 protein coding gene Chr10:69803961-69806172 (-)
CAST/EiJ no annotation
CBA/J ENSMUSG00210048954
 protein coding gene Chr10:72362655-72364839 (-)
DBA/2J ENSMUSG00185053110
 protein coding gene Chr10:72704957-72707141 (-)
FVB/NJ ENSMUSG00205026842
 protein coding gene Chr10:72397956-72400142 (-)
JF1/MsJ no annotation
LP/J ENSMUSG00230044748
 protein coding gene Chr10:74474541-74476726 (-)
NOD/ShiLtJ ENSMUSG00190039063
 protein coding gene Chr10:72682473-72684657 (-)
NZO/HlLtJ ENSMUSG00225046036
 protein coding gene Chr10:78771025-78773210 (-)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ no annotation



Homology
more
  • Human Ortholog
    DDT, D-dopachrome tautomerase
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DDT, D-dopachrome tautomerase
  • Synonyms
    DDCT, D-DT, MIF-2, MIF2
  • Links
    NCBI Gene ID: 1652
    UniProt: P30046

  • Chr Location
    22q11.23; chr22:23970542-23980525 (-)  GRCh38
  • Human Ortholog
    DDTL, D-dopachrome tautomerase like
  • Synonyms
    KB-226F1.2
  • Links
    NCBI Gene ID: 100037417
    UniProt: A6NHG4

  • Chr Location
    22q11.23; chr22:23966888-23980525 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 1 allele in 1 genetic background
    1 phenotype from multigenic genotypes
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Cardiomyocyte-specific knock-out mice show increased cardiac dysfunction and necrosis after ischemia-reperfusion.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    703
  • Tissues
    60
  • cDNA Data
    106
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 13202 NCBI Gene Model | MGI Sequence Detail 2142 C57BL/6J ±  kb
    transcript NM_010027 RefSeq | MGI Sequence Detail 609 Not Specified  
    polypeptide O35215 UniProt | EBI | MGI Sequence Detail 118 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 118
      Genomic 12
      cDNA 106

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGI:2143922
    References
    more
    • Summaries
      All 60
      Developmental Gene Expression 5
      Gene Ontology 8
      Phenotypes 21
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:376738 Kim SH, et al., Dysregulated alveolar type 2 epithelial cell proteostasis promotes fibrogenic macrophage migration inhibitory factor-CD74 signaling. Sci Transl Med. 2025 Dec 3;17(827):eadr2277
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    09/15/2026
    MGI 6.29     		The Jackson Laboratory