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Ddt Gene Detail
Summary
  • Symbol
    Ddt
  • Name
    D-dopachrome tautomerase
  • Feature Type
    protein coding gene
  • IDs
    MGI:1298381
    NCBI Gene: 13202
  • Gene Overview
    MyGene.info: DDT
Location & Maps
more
  • Sequence Map
    Chr10:75771230-75773414 bp, - strand
  • From VEGA annotation of GRCm38

    Mouse Genome Browser

  • Download
    Sequence
      2185 bp   ±  kb flank

  • Genome Browsers
Homology
more
  • Human Ortholog
    DDT, D-dopachrome tautomerase
  • Vertebrate Orthologs
    9
  • Human Ortholog
    DDT, D-dopachrome tautomerase
    Orthology source: HomoloGene
  • Synonyms
    DDCT
  • Links
    NCBI Gene ID: 1652
    neXtProt AC: NX_P30046

  • Chr Location
    22q11.23; chr22:23971365-23979828 (-)  GRCh38.p2

  • HomoloGene
    Vertebrate Homology Class 1038
    1 human;1 mouse;1 rat;1 rhesus macaque;1 cattle;1 dog;1 chicken;1 western clawed frog;1 zebrafish
  • HCOP
    human homology predictions: DDT
  • Gene Tree
    Ddt
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    9 phenotype references
  • All Mutations and Alleles
    4
  • Chemically induced (other)
    1
  • Targeted
    3
  • Genomic Mutations
    1 involving Ddt
  • Incidental Mutations
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
  • GO References
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
receptor
receptor binding
RNA binding
transcription
transferase
transporter
Biological Process

nucleic acid-templated transcription
carbohydrate derivative metabolism
cell death
cell differentiation
cell proliferation
cellular component organization
establishment of localization
homeostatic process
immune system process
lipid metabolic process
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
  • Tissues
  • cDNA Data
  • Literature Summary
Interactions
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Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic OTTMUSG00000037564 VEGA Gene Model | MGI Sequence Detail 2185 C57BL/6J ±  kb
transcript OTTMUST00000096835 VEGA | MGI Sequence Detail 649 Not Applicable  
polypeptide OTTMUSP00000054152 VEGA | MGI Sequence Detail 118 Not Applicable  
For the selected sequence
Polymorphisms
less
  • SNPs within 2kb
    45 from dbSNP Build 142
  • RFLP
Protein
Information
less
  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000006353 D-dopachrome decarboxylase
  • PDB
  • EC
  • InterPro Domains
    IPR001398 Macrophage migration inhibitory factor
    IPR019829 Macrophage migration inhibitory factor, conserved site
    IPR014347 Tautomerase/MIF superfamily
Molecular
Reagents
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  • All nucleic 117
    Genomic 12
    cDNA 105

    Microarray probesets 3
Other
Accession IDs
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MGI:2143922
References
more
  • Summaries
    All 36
    Developmental Gene Expression 3
    Gene Ontology 3
    Phenotypes 9
  • Earliest
    J:48150 Cole SE, et al., Physical mapping of the evolutionary boundary between human chromosomes 21 and 22 on mouse chromosome 10. Genomics. 1998 May 15;50(1):109-11
  • Latest
    J:217785 Rajasekaran D, et al., Targeting distinct tautomerase sites of D-DT and MIF with a single molecule for inhibition of neutrophil lung recruitment. FASEB J. 2014 Nov;28(11):4961-71

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
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last database update
05/17/2016
MGI 6.03
The Jackson Laboratory